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Influence of the pore size and porosity of selective laser melted Ti6Al4V ELI porous scaffold on cell proliferation, osteogenesis and bone ingrowth
Open accessAbstract
This paper systematically investigates the biomedical performance of selective laser melted (SLM) porous Ti6Al4V ELI scaffolds for bone implantation through in vitro and in vivo experiments. Scaffolds with pore sizes of 500 μm, 600 μm and 700 μm and porosities of 60% and 70% were manufactured in order to explore the optimum pore size and porosity. Rat bone marrow mesenchymal stem cells (rBMMSCs) were used in the in vitro experiments. Cell Counting Kit-8, live/dead staining and scanning electron microscope were used to assess the cytotoxicity of the porous scaffolds. DNA content quantification was performed to investigate cell proliferation on the porous scaffolds. The osteogenic differentiation of cells was measured by alkaline phosphatase (ALP) activity and osteogenic gene expressions, including bone morphogenetic protein-2 (BMP-2), collagen type 1α1 (COL-1), osteocalcin (OCN), osteopontin (OPN) and runt-related transcription factor-2 (RUNX-2). The Sprague-Dawley (SD) rat models with distal femoral condyles defect were used in the in vivo experiments. Micro-CT analysis and histological analysis were performed after implantation surgery to reveal the bone ingrowth into the porous scaffolds. All in vitro data were analyzed by one-way ANOVA followed by Tukey post hoc tests, in vivo data were analyzed using Kruskall-Wallis ANOVA and Conover-Inman post-hoc test. Based on the in vitro and in vivo experiments, it is found that the porous scaffolds manufactured by SLM did not induce a cytotoxic effect. Among all the porous scaffolds, the scaffold with a pore size of 500 μm and porosity of 60% showed the best cell proliferation and osteogenic differentiation (in vitro experiments) and bone ingrowth (in vivo experiments).
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Cites
RESISTANCE OF SOLID SURFACES TO WETTING BY WATER
Wenzel, R. N. (1936) · Industrial & Engineering Chemistry · doi:10.1021/ie50320a024 · Cited by 13,316
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Cited by
Zhu, G., Zhang, T., Chen, M., Yao, K., Huang, X., Zhang, B., Li, Y., Liu, J., Wang, Y., & Zhao, Z. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.03.043 · Cited by 494
Scaffolds for bone-tissue engineering
Lee, S. S., Du, X., Kim, I., & Ferguson, S. J. (2022) · Matter · doi:10.1016/j.matt.2022.06.003 · Cited by 375
Promotion of Bone Regeneration Using Bioinspired PLGA/MH/ECM Scaffold Combined with Bioactive PDRN
Kim, D.-S., Lee, J.-K., Jung, J.-W., Baek, S.-W., Kim, J. H., Heo, Y., Kim, T.-H., & Han, D. K. (2021) · Materials · doi:10.3390/ma14154149 · Cited by 47
Vasconcelos, E. V., da Luz, F. B., da Paz, S. P. A., dos Reis, M. A. L., da Silva, A. C. R., Passos, M. F., Barboza, C. A. G., Monteiro, S. N., & Candido, V. S. (2023) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2023.02.171 · Cited by 35
Metadata
- Authors
- Chen, Z., Yan, X., Yin, S., Liu, L., Liu, X., Zhao, G., Ma, W., Qi, W., Ren, Z., Liao, H., Liu, M., Cai, D., & Fang, H.
- Venue
- Materials Science and Engineering: C
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 106
- Pages
- 110289
- ISSN
- 0928-4931 (ISSN-L)
- OpenAlex
- W2979526779
- Cited by
- 324
- References
- 2
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Chen, Z., Yan, X., Yin, S., Liu, L., Liu, X., Zhao, G., Ma, W., Qi, W., Ren, Z., Liao, H., Liu, M., Cai, D., & Fang, H. (2020). Influence of the pore size and porosity of selective laser melted Ti6Al4V ELI porous scaffold on cell proliferation, osteogenesis and bone ingrowth. Materials Science and Engineering: C. https://doi.org/10.1016/j.msec.2019.110289
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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