The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Toxicology and clinical potential of nanoparticles
Open accessAbstract
In recent years, nanoparticles (NPs) have increasingly found practical applications in technology, research and medicine. The small particle size coupled to their unique chemical and physical properties is thought to underlie their exploitable biomedical activities. Here, we review current toxicity studies of NPs with clinical potential. Mechanisms of cytotoxicity are discussed and the problem of extrapolating knowledge gained from cell-based studies into a human scenario is highlighted. The so-called 'proof-of-principle' approach, whereby ultra-high NP concentrations are used to ensure cytotoxicity, is evaluated on the basis of two considerations; firstly, from a scientific perspective, the concentrations used are in no way related to the actual doses required which, in many instances, discourages further vital investigations. Secondly, these inaccurate results cast doubt on the science of nanomedicine and thus, quite dangerously, encourage unnecessary alarm in the public. In this context, the discrepancies between in vitro and in vivo results are described along with the need for a unifying protocol for reliable and realistic toxicity reports.
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Cites
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
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Hybrid antimicrobial enzyme and silver nanoparticle coatings for medical instruments
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Airborne microplastics: consequences to human health?
Prata, J. C. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2017.11.043 · Cited by 1,852
Electrically-Transduced Chemical Sensors Based on Two-Dimensional Nanomaterials
Meng, Z., Stolz, R. M., Mendecki, L., & Mirica, K. A. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00311 · Cited by 773
Ali, M. R. K., Rahman, M. A., Wu, Y., Han, T., Peng, X., Mackey, M. A., Wang, D., Shin, H. J., Chen, Z. G., Xiao, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619302114 · Cited by 319
Mutuku, C., Gazdag, Z., & Melegh, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03334-0 · Cited by 280
Metadata
- Authors
- Yildirimer, L., Thanh, N. T. K., Loizidou, M., & Seifalian, A. M.
- Venue
- Nano Today
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 6
- Issue
- 6
- Pages
- 585-607
- ISSN
- 1748-0132 (ISSN-L)
- OpenAlex
- W2117981139
- Cited by
- 676
- References
- 6
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
