The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Open accessAbstract
Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in gene transcriptional control, could be involved in the development of sporadic Alzheimer's disease (AD). We therefore investigated whether miRNAs could participate in the regulation of APP gene expression. We show that miRNAs belonging to the miR-20a family (that is, miR-20a, miR-17-5p and miR-106b) could regulate APP expression in vitro and at the endogenous level in neuronal cell lines. A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. We thus identify miRNAs as novel endogenous regulators of APP expression, suggesting that variations in miRNA expression could contribute to changes in APP expression in the brain during development and disease. This possibility is further corroborated by the observation that a statistically significant decrease in miR-106b expression was found in sporadic AD patients.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Notably, miR-106b-5p also targets APP in the HeLa cell line [117].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [117]
In the citing paper
“miR-132-3p was downregulated in AD brains [56,84] and EVs from plasma [79] and CSF [49].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [56]
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · cited 1×
“The Aβ peptides accumulating in the brain of AD patients result from proteolytic cleavage of APP by β- and γ-secretases (De Strooper et al., 1998; Vassar et al., 1999; Haass, 2004).”
BackgroundRAS Is Regulated by the let-7 MicroRNA Family
Johnson, S., Großhans, H., Shingara, J., Byrom, M., JARVIS, R., Cheng, A., Labourier, E., Reinert, K. L., Brown, D., & Slack, F. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.014 · Cited by 3,699
A microRNA polycistron as a potential human oncogene
He, L., Thomson, J. M., Hemann, M. T., Hernando, E., Mu, D., Goodson, S. G., Powers, S., Cordon‐Cardo, C., Lowe, S. W., Hannon, G. J., et al. (2005) · Nature · doi:10.1038/nature03552 · Cited by 3,642
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429
c-Myc-regulated microRNAs modulate E2F1 expression
O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., & Mendell, J. T. (2005) · Nature · doi:10.1038/nature03677 · Cited by 2,347
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818
Cited by
Sorted by citations
Repression of α-synuclein expression and toxicity by microRNA-7
Junn, E., Lee, K.-W., Jeong, B. S., Chan, T. W., Im, J.-Y., & Mouradian, M. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906277106 · Cited by 634
Identifying miRNAs, targets and functions
Liu, B., Li, J., & Cairns, M. J. (2014) · Briefings in Bioinformatics · doi:10.1093/bib/bbs075 · Cited by 563
The Role of MicroRNAs in Human Diseases.
Ardekani, A. M., & Naeini, M. M. (2010) · Europe PMC (PubMed Central) · Cited by 554
A blood based 12-miRNA signature of Alzheimer disease patients
Leidinger, P., Backes, C., Deutscher, S., Schmitt, K., Mueller, S. C., Frese, K., Haas, J., Ruprecht, K., Paul, F., Stähler, C., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-7-r78 · Cited by 509
Alterations of the microRNA network cause neurodegenerative disease
Hébert, S. S., & De Strooper, B. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.003 · Cited by 452
Self-citation
Metadata
- Authors
- Hébert, S. S., Horré, K., Nicolaï, L., Bergmans, B., Papadopoulou, A. S., Delacourte, A., & De Strooper, B.
- Affiliations
- KU Leuven (BE)
- Inserm (FR)
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 33
- Issue
- 3
- Pages
- 422-428
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2072484559
- Cited by
- 436
- References
- 39
- Citations by year
- 2026: 7 · 2025: 27 · 2024: 19 · 2023: 24 · 2022: 22 · 2021: 29 · 2020: 19 · 2019: 24 · 2018: 16 · 2017: 21 · 2016: 26 · 2015: 26 · 2014: 27 · 2013: 39 · 2012: 25
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- microRNA, amyloid precursor protein, Alzheimer's disease, miR-20a, miR-17-5p, miR-106b, gene expression regulation, neuronal differentiation, brain development, sporadic Alzheimer's disease, familial Alzheimer's disease
- MeSH terms
- Actins, Animals, Brain, Cell Line, Cells, Cultured, Densitometry, Gene Expression Regulation, Humans, Neurons, Receptors, Cell Surface, RNA, Messenger, Transfection, Blotting, Northern, Blotting, Western, Amyloid beta-Protein Precursor, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Neurogenesis, Protease Nexins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
