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MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Open accessAbstract
Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in gene transcriptional control, could be involved in the development of sporadic Alzheimer's disease (AD). We therefore investigated whether miRNAs could participate in the regulation of APP gene expression. We show that miRNAs belonging to the miR-20a family (that is, miR-20a, miR-17-5p and miR-106b) could regulate APP expression in vitro and at the endogenous level in neuronal cell lines. A tight correlation between these miRNAs and APP was found during brain development and in differentiating neurons. We thus identify miRNAs as novel endogenous regulators of APP expression, suggesting that variations in miRNA expression could contribute to changes in APP expression in the brain during development and disease. This possibility is further corroborated by the observation that a statistically significant decrease in miR-106b expression was found in sporadic AD patients.
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“Notably, miR-106b-5p also targets APP in the HeLa cell line [117].”
From MicroRNAs in brain cholesterol metabolism and their implications for Alzheimer's disease (2016) · cites this paper as [117]
In the citing paper
“miR-132-3p was downregulated in AD brains [56,84] and EVs from plasma [79] and CSF [49].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [56]
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Metadata
- Authors
- Hébert, S. S., Horré, K., Nicolaï, L., Bergmans, B., Papadopoulou, A. S., Delacourte, A., & De Strooper, B.
- Affiliations
- KU Leuven (BE)
- Inserm (FR)
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 33
- Issue
- 3
- Pages
- 422-428
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2072484559
- Cited by
- 436
- References
- 39
- Citations by year
- 2026: 7 · 2025: 27 · 2024: 19 · 2023: 24 · 2022: 22 · 2021: 29 · 2020: 19 · 2019: 24 · 2018: 16 · 2017: 21 · 2016: 26 · 2015: 26 · 2014: 27 · 2013: 39 · 2012: 25
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Lirias (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- microRNA, amyloid precursor protein, Alzheimer's disease, miR-20a, miR-17-5p, miR-106b, gene expression regulation, neuronal differentiation, brain development, sporadic Alzheimer's disease, familial Alzheimer's disease
- MeSH terms
- Actins, Animals, Brain, Cell Line, Cells, Cultured, Densitometry, Gene Expression Regulation, Humans, Neurons, Receptors, Cell Surface, RNA, Messenger, Transfection, Blotting, Northern, Blotting, Western, Amyloid beta-Protein Precursor, Reverse Transcriptase Polymerase Chain Reaction, MicroRNAs, Mice, Neurogenesis, Protease Nexins
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