MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease
Open accessAbstract
Alzheimer’s disease (AD) is a neurodegenerative disease with dysfunction of memory, language and thinking. More than 55 million people were diagnosed with AD or other dementia around the world in 2020. The pathology of AD is still unclear and there are no applicable therapies for AD. MicroRNAs (miRNAs) play key roles in AD pathology and have great potential for the diagnosis and treatment of AD. Extracellular vesicles (EVs) widely exist in body fluids such as blood and cerebrospinal fluid (CSF) and contain miRNAs that are involved in cell-to-cell communication. We summarized the dysregulated miRNAs in EVs derived from the different body fluids of AD patients, as well as their potential function and application in AD. We also compared these dysregulated miRNAs in EVs to those in the brain tissues of AD patients aiming to provide a comprehensive view of miRNAs in AD. After careful comparisons, we found that miR-125b-5p and miR-132-3p were upregulated and downregulated in several different brain tissues of AD and EVs of AD, respectively, suggesting their value in AD diagnosis based on EV miRNAs. Furthermore, miR-9-5p was dysregulated in EVs and different brain tissues of AD patients and had also been tested as a potential therapy for AD in mice and human cell models, suggesting that miR-9-5p could be used to design new therapies for AD.
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
Shedding light on the cell biology of extracellular vesicles
van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works
Scheltens, P., De Strooper, B., Kivipelto, M., Holstege, H., Chételat, G., Teunissen, C. E., Cummings, J., & van der Flier, W. M. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32205-4 · Cited by 5,465 · see citing works
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462 · see citing works
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works
MicroRNA genes are transcribed by RNA polymerase II
Lee, Y., Kim, M., Han, J., Yeom, K.-H., Lee, S., Baek, S. H., & Kim, V. N. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600385 · Cited by 4,355 · see citing works
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444 · see citing works
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294 · see citing works
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
Long, J. M., & Holtzman, D. M. (2019) · Cell · doi:10.1016/j.cell.2019.09.001 · Cited by 3,204 · see citing works
Routes and mechanisms of extracellular vesicle uptake
Mulcahy, L. A., Pink, R. C., & Carter, D. R. F. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.24641 · Cited by 2,832 · see citing works
Processing of primary microRNAs by the Microprocessor complex
Denli, A. M., Tops, B. B. J., Plasterk, R. H. A., Ketting, R. F., & Hannon, G. J. (2004) · Nature · doi:10.1038/nature03049 · Cited by 2,784 · see citing works
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543 · see citing works
2022 Alzheimer's disease facts and figures
Anonymous (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12638 · Cited by 2,384 · see citing works
Ballard, C., Gauthier, S., Corbett, A., Brayne, C., Aarsland, D., & Jones, E. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61349-9 · Cited by 2,336 · see citing works
Characterization of extracellular circulating microRNA
Turchinovich, A., Weiz, L., Langheinz, A., & Burwinkel, B. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr254 · Cited by 1,941 · see citing works
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature · doi:10.1038/nature11087 · Cited by 1,293 · see citing works
Synergy between amyloid-β and tau in Alzheimer’s disease
Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242 · see citing works
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., & De Strooper, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710263105 · Cited by 1,183 · see citing works
Crescitelli, R., Lässer, C., Szabó, T. G., Kittel, Á., Eldh, M., Dianzani, I., Buzás, E. I., & Lötvall, J. O. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20677 · Cited by 996 · see citing works
Mandelkow, E., & Mandelkow, E. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01368-3 · Cited by 951 · see citing works
Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., Kelnar, K., Kemppainen, J., Brown, D., Chen, C., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14103 · Cited by 943 · see citing works
Wang, W., Rajeev, B. W., Stromberg, A. J., Ren, N., Tang, G., Huang, Q., Rigoutsos, I., & Nelson, P. T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5065-07.2008 · Cited by 827 · see citing works
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
Holth, J. K., Fritschi, S. K., Wang, C., Pedersen, N. P., Cirrito, J. R., Mahan, T. E., Finn, M. B., Manis, M., Geerling, J. C., Fuller, P. M., et al. (2019) · Science · doi:10.1126/science.aav2546 · Cited by 813 · see citing works
microPrimer: the biogenesis and function of microRNA
Du, T., & Zamore, P. D. (2005) · Development · doi:10.1242/dev.02070 · Cited by 813 · see citing works
Extracellular vesicles round off communication in the nervous system
Budnik, V., Ruiz-Cañada, C., & Wendler, F. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.29 · Cited by 712 · see citing works
Biological functions of microRNAs: a review
Huang, Y., Shen, X. J., Zou, Q., Wang, S. P., Tang, S. M., & Zhang, G. Z. (2010) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-010-0050-6 · Cited by 650 · see citing works
Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk
Efthymiou, A. G., & Goate, A. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0184-x · Cited by 562 · see citing works
Alzheimer’s disease drug development pipeline: 2021
Cummings, J., Lee, G., Zhong, K., Fonseca, J., & Taghva, K. (2021) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12179 · Cited by 539 · cited 1× · see citing works
“Based on their important roles in AD pathology, Tau and Aβ are also important targets in AD treatment [10].”
BackgroundEvidence for natural antisense transcript-mediated inhibition of microRNA function
Faghihi, M., Zhang, M., Huang, J., Modarresi, F., van der Brug, M. P., Nalls, M., Cookson, M., Laurent, G. S. S., & Wahlestedt, C. (2010) · Genome Biology · doi:10.1186/gb-2010-11-5-r56 · Cited by 525 · see citing works
New insights into the role of TREM2 in Alzheimer’s disease
Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489 · see citing works
Kawamata, T., & Tomari, Y. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.03.009 · Cited by 481 · see citing works
Alteration of the microRNA network during the progression of Alzheimer's disease
Lau, P., Bossers, K., Janky, R., Salta, E., Frigerio, C. S., Barbash, S., Rothman, R., Sierksma, A. S. R., Thathiah, A., Greenberg, D., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201974 · Cited by 474 · see citing works
The antimicrobial protection hypothesis of Alzheimer’s disease
Moir, R. D., Lathe, R., & Tanzi, R. E. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.06.3040 · Cited by 456 · see citing works
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
Hébert, S. S., Horré, K., Nicolaï, L., Bergmans, B., Papadopoulou, A. S., Delacourte, A., & De Strooper, B. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.11.009 · Cited by 436 · see citing works
Wang, C., Najm, R., Xu, Q., Jeong, D.-E., Walker, D., Balestra, M. E., Yoon, S. Y., Yuan, H., Li, G., Miller, Z. A., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0004-z · Cited by 428 · see citing works
Lugli, G., Cohen, A. M., Bennett, D. A., Shah, R. C., Fields, C. J., Hernandez, A. G., & Smalheiser, N. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139233 · Cited by 423 · see citing works
Human CNS barrier-forming organoids with cerebrospinal fluid production
Pellegrini, L., Bonfio, C., Chadwick, J., Begum, F., Skehel, M., & Lancaster, M. A. (2020) · Science · doi:10.1126/science.aaz5626 · Cited by 412 · see citing works
Exosomal miRNAs as cancer biomarkers and therapeutic targets
Thind, A., & WILSON, C. G. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.31292 · Cited by 402 · see citing works
Burgos, K., Malenica, I., Metpally, R., Courtright, A., Rakela, B., Beach, T., Shill, H., Adler, C., Sabbagh, M., Villa, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094839 · Cited by 385 · see citing works
Extracellular vesicles as mediators of neuron-glia communication
Frühbeis, C., Fröhlich, D., Kuo, W. P., & Krämer‐Albers, E. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00182 · Cited by 383 · see citing works
Lukiw, W. J., Zhao, Y., & Cui, J. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805371200 · Cited by 380 · see citing works
Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics
Lucey, B. P., Hicks, T. J., McLeland, J. S., Toedebusch, C. D., Boyd, J., Elbert, D. L., Patterson, B. W., Baty, J., Morris, J. C., Ovod, V., et al. (2018) · Annals of Neurology · doi:10.1002/ana.25117 · Cited by 362 · see citing works
Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity
Xu, B., Zhang, Y., Du, X.-F., Li, J., Zi, H.-X., Bu, J.-W., Yan, Y., Han, H., & Du, J.-L. (2017) · Cell Research · doi:10.1038/cr.2017.62 · Cited by 354 · see citing works
MAPs, MARKs and microtubule dynamics
Drewes, G., Ebneth, A., & Mandelkow, E. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01245-6 · Cited by 346 · see citing works
Sethi, P., & Lukiw, W. J. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.052 · Cited by 339 · see citing works
MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer’s disease
Banzhaf‐Strathmann, J., Benito, E., May, S., Arzberger, T., Tahirovic, S., Kretzschmar, H., Fischer, A., & Edbauer, D. (2014) · The EMBO Journal · doi:10.15252/embj.201387576 · Cited by 326 · see citing works
Hébert, S. S., Papadopoulou, A. S., Smith, P. Y., Galas, M., Planel, E., Silahtaroglu, A., Sergeant, N., Buée, L., & Strooper, B. D. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq311 · Cited by 323 · see citing works
Nunez-Iglesias, J., Liu, C.-C., Morgan, T. E., Finch, C. E., & Zhou, X. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008898 · Cited by 320 · see citing works
MicroRNAs in Alzheimer’s Disease
Wang, M., Qin, L., & Tang, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00153 · Cited by 307 · see citing works
Shioya, M., Obayashi, S., Tabunoki, H., Arima, K., Saito, Y., Ishida, T., & Satoh, J. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01076.x · Cited by 301 · see citing works
Wong, H. K., Veremeyko, T., Patel, N., Lemere, C. A., Walsh, D. M., Esau, C., Vanderburg, C. R., & Krichevsky, A. M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt164 · Cited by 293 · see citing works
Absalon, S., Kochanek, D. M., Raghavan, V., & Krichevsky, A. M. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1327-13.2013 · Cited by 259 · see citing works
Cui, J. G., Li, Y. Y., Zhao, Y., Bhattacharjee, S., & Lukiw, W. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178848 · Cited by 240 · see citing works
Müller, M., Kuiperij, H. B., Claassen, J. A. H. R., Küsters, B., & Verbeek, M. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.005 · Cited by 234 · see citing works
Yang, T., Liu, C. G., Gao, S. C., Zhang, Y., & Wang, P. C. (2018) · PubMed · doi:10.3967/bes2018.011 · Cited by 230 · see citing works
Liu, C., Song, J., Zhang, Y., & Wang, P. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2484 · Cited by 221 · see citing works
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
Smith, P. Y., Hashimi, A. A., Girard, J., Delay, C., & Hébert, S. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07097.x · Cited by 209 · see citing works
Santa‐María, I., Alaniz, M. E., Renwick, N. M., Cela, C., Fulga, T. A., Vactor, D. V., Tuschl, T., Clark, L. N., Shelanski, M. L., McCabe, B. D., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78421 · Cited by 202 · see citing works
miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients
Cha, D. J., Mengel, D., Mustapić, M., Liu, W., Selkoe, D. J., Kapogiannis, D., Galasko, D. R., Rissman, R. A., Bennett, D. A., & Walsh, D. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01208 · Cited by 200 · see citing works
Long, J. M., Ray, B., & Lahiri, D. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366336 · Cited by 198 · see citing works
Long, J. M., Ray, B., & Lahiri, D. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.518241 · Cited by 187 · see citing works
Sarkar, S., Jun, S., Rellick, S., Quintana, D. D., Cavendish, J. Z., & Simpkins, J. W. (2016) · Brain Research · doi:10.1016/j.brainres.2016.05.026 · Cited by 185 · see citing works
Gámez‐Valero, A., Campdelacreu, J., Vilas, D., Ispierto, L., Reñé, R., Álvarez, R., Armengol, M. P., Borràs, F. E., & Beyer, K. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0169-5 · Cited by 176 · see citing works
McKeever, P. M., Schneider, R., Taghdiri, F., Weichert, A., Multani, N., Brown, R. A., Boxer, A. L., Karydas, A., Miller, B. L., Robertson, J., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1032-x · Cited by 175 · see citing works
Jahangard, Y., Monfared, H., Moradi, A., Zare, M., Mirnajafi‐Zadeh, J., & Mowla, S. J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00564 · Cited by 169 · see citing works
MicroRNA-9 Reveals Regional Diversity of Neural Progenitors along the Anterior-Posterior Axis
Bonev, B., Pisco, A. O., & Papalopulu, N. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.11.018 · Cited by 157 · see citing works
2017 Alzheimers Disease Facts and Figures
Alzheimers Association (2017) · Issue Lab (Candid) · Cited by 150 · see citing works
Role of BACE1 in Alzheimer’s synaptic function
Das, B., & Yan, R. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0093-5 · Cited by 122 · see citing works
Serpente, M., Fenoglio, C., D’Anca, M., Arcaro, M., Sorrentino, F., Visconte, C., Arighi, A., Fumagalli, G., Porretti, L., Cattaneo, A., et al. (2020) · Cells · doi:10.3390/cells9061443 · Cited by 115 · see citing works
The Role of microRNAs in Alzheimer’s Disease and Their Therapeutic Potentials
Shaik, M. M., Tamargo, I. A., Abubakar, M. B., Kamal, M. A., Greig, N. H., & Gan, S. H. (2018) · Genes · doi:10.3390/genes9040174 · Cited by 114 · see citing works
MicroRNA in Alzheimer’s disease: an exploratory study in brain, cerebrospinal fluid and plasma
Bekris, L. M., Lutz, F., Montine, T. J., Yu, C., Tsuang, D. W., Peskind, E. R., & Leverenz, J. B. (2013) · Biomarkers · doi:10.3109/1354750x.2013.814073 · Cited by 112 · see citing works
Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease.
Lei, X., Lei, L., Zhang, Z., Zhang, Z., & Cheng, Y. (2015) · Europe PMC (PubMed Central) · Cited by 111 · see citing works
Cheng, C., Li, W., Zhang, Z., Yoshimura, S., Hao, Q., Zhang, C., & Wang, Z. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.381392 · Cited by 111 · see citing works
Self-citationHébert, S. S., Wang, W.-X., Zhu, Q., & Nelson, P. T. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-122350 · Cited by 110 · see citing works
Drouin‐Ouellet, J., Lau, S., Brattås, P. L., Ottosson, D. R., Pircs, K., Grassi, D. A., Collins, L., Vuono, R., Sjöland, A. A., Westergren‐Thorsson, G., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201607471 · Cited by 105 · see citing works
Dong, Z., Gu, H., Guo, Q., Liang, S., Xue, J., Yao, F., Liu, X., Li, F., Liu, H., Sun, L., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02323-y · Cited by 103 · see citing works
Ouyang, Q., Liu, K., Zhu, Q., Deng, H., Le, Y., Ouyang, W., Yan, X., Zhou, W., & Tong, J. (2022) · Small · doi:10.1002/smll.202107534 · Cited by 103 · see citing works
Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy
Iranifar, E., Seresht, B. M., Momeni, F., Fadaei, E., Mehr, M. H., Ebrahimi, Z., Rahmati, M., Kharazinejad, E., & Mirzaei, H. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27214 · Cited by 101 · see citing works
MIRNAS in Astrocyte-Derived Exosomes as Possible Mediators of Neuronal Plasticity
Lafourcade, C., Ramírez, J. P., Luarte, A., Fernández, A., & Wyneken, Ú. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39916 · Cited by 98 · see citing works
Cheng, L., Vella, L. J., Barnham, K. J., McLean, C., Masters, C. L., & Hill, A. F. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1766822 · Cited by 95 · see citing works
Extracellular Vesicles of Alzheimer’s Disease Patients as a Biomarker for Disease Progression
Aharon, A., Specktor, P., Ahmad, R. S., Horrany, N., Sabbach, A., Brenner, B., & Aharon‐Peretz, J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02013-1 · Cited by 90 · see citing works
Parsi, S., Smith, P. Y., Goupil, C., Dorval, V., & Hébert, S. S. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.33 · Cited by 89 · see citing works
Nie, C., Sun, Y., Zhen, H., Guo, M. L., Ye, J., Liu, Z., Yang, Y. X., & Zhang, X. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00438 · Cited by 89 · see citing works
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation
Subramanian, M., Hyeon, S. J., Das, T., Suh, Y. S., Kim, Y. K., Lee, J.-S., Song, E. J., Ryu, H., & Yu, K. (2021) · Nature Communications · doi:10.1038/s41467-021-23597-9 · Cited by 69 · see citing works
Li, F., Xie, X.-Y., Sui, X.-F., Wang, P., Chen, Z., & Zhang, J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.044 · Cited by 66 · see citing works
CHANG, F., ZHANG, L.-H., XU, W.-P., JING, P., & ZHAN, P.-Y. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2013 · Cited by 58 · see citing works
Li, S., Yan, Y., Jiao, Y., Gao, Z., Xia, Y., Kong, L., Yao, Y., Tao, Z., Song, J., Yan, Y., et al. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0793-9 · Cited by 57 · see citing works
MiR-16 regulates cell death in Alzheimer's disease by targeting amyloid precursor protein.
Zhang, B., Cf, C., Ah, W., & Qf, L. (2015) · PubMed · Cited by 53 · see citing works
BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
Zhang, L., Qian, Y., Li, J., Zhou, X., Xu, H. J., Yan, J., Xiang, J., Yuan, X., Sun, B., Sisodia, S. S., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102942 · Cited by 53 · see citing works
Li, S., Gao, P., Wang, L., Yan, Y., Xia, Y., Song, J., Li, H., & Yang, J. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00340 · Cited by 52 · see citing works
Differential microRNA expression analyses across two brain regions in Alzheimer’s disease
Dobričić, V., Schilling, M., Schulz, J., Zhu, L., Zhou, C.-W., Fuß, J., Franzenburg, S., Zhu, L., Parkkinen, L., Lill, C. M., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02108-4 · Cited by 52 · see citing works
Peng, D., Wang, Y., Xiao, Y., Peng, M., Mai, W., Hu, B., Jia, Y., Chen, H., Yang, Y., Xiang, Q., et al. (2022) · Theranostics · doi:10.7150/thno.70951 · Cited by 51 · see citing works
Durur, D. Y., Tastan, B., Tüfekçi, K. U., Olcum, M., Uzuner, H., Karakülah, G., Yener, G., & Genç, Ş. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02012-y · Cited by 49 · see citing works
ABCA1‐Labeled Exosomes in Serum Contain Higher MicroRNA‐193b Levels in Alzheimer’s Disease
Liu, C., Zhao, Y., Lu, Y., & Wang, P. (2021) · BioMed Research International · doi:10.1155/2021/5450397 · Cited by 48 · see citing works
MiR-9-5p inhibits mitochondrial damage and oxidative stress in AD cell models by targeting GSK-3β
Liu, J., Zuo, X., Han, J., Dai, Q., Xu, H., Liu, Y., & Cui, S. (2020) · Bioscience, Biotechnology, and Biochemistry · doi:10.1080/09168451.2020.1797469 · Cited by 47 · see citing works
Bussy, A., Snider, B., Coble, D., Xiong, C., Fagan, A., Cruchaga, C., Benzinger, T., Gordon, B., Hassenstab, J. J., Bateman, R., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.011 · Cited by 45 · see citing works
Ishikawa, M., Aoyama, T., Shibata, S., Sone, T., Miyoshi, H., Watanabe, H., Nakamura, M., Morota, S., Uchino, H., Yoo, A. S. J., et al. (2020) · Cells · doi:10.3390/cells9030532 · Cited by 37 · see citing works
Eriksson, H., Fereshtehnejad, S., Falahati, F., Farahmand, B. Y., Religa, D., & Eriksdotter, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132273 · Cited by 33 · see citing works
MicroRNA-135a in ABCA1-labeled Exosome is a Serum Biomarker Candidate for Alzheimer's Disease.
Liu, C. G., Meng, S., Li, Y., Lu, Y., Zhao, Y., & Wang, P. C. (2021) · PubMed · doi:10.3967/bes2021.004 · Cited by 32 · see citing works
Choi, S., Lee, B., Woo, J. H., Jeong, J. B., Jun, I., & Kim, E. K. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.03.012 · Cited by 31 · see citing works
In Vitro Amyloid Aggregate Forming Ability of TGFBI Mutants that Cause Corneal Dystrophies
Yam, G. H., Wang, R. C., Jhanji, V., Choy, K. W., Baum, L., & Pang, C. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-9068 · Cited by 30 · see citing works
Wątroba, M., & Szukiewicz, D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.962769 · Cited by 29 · see citing works
Furr, J. W., Morales‐Scheihing, D., Manwani, B., Lee, J., & McCullough, L. D. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08568-0 · Cited by 28 · see citing works
MicroRNA-Target Interaction Regulatory Network in Alzheimer’s Disease
Turk, A., Kunej, T., & Peterlin, B. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11121275 · Cited by 19 · see citing works
Flagged first, then by citations
3 of the 110 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Exosome-based therapies for inflammatory disorders: a review of recent advances
Saleem, M., Shahzad, K. A., Marryum, M., Singh, S., Zhou, Q., Du, S., Wang, S., Shao, C., & Shaikh, I. I. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04107-2 · Cited by 68 · see citing works
Ralston, K., Newman, C., Clauson, A. L., Guthrie, J. F., & Buzby, J. C. (2008) · Cited by 33 · see citing works
Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs
Xu, X., Liu, R., Li, Y., Zhang, C., Guo, C., Zhu, J., Dong, J., Ouyang, L., & Momeni, M. R. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03954-7 · Cited by 17 · see citing works
Bir, A., Ghosh, A., Chauhan, A., Saha, S., Saini, A. K., Bisaglia, M., & Chakrabarti, S. (2024) · Antioxidants · doi:10.3390/antiox13030316 · Cited by 17 · see citing works
Petracci, I., Bellini, S., Goljanek‐Whysall, K., Quinlan, L. R., Fiszer, A., Cakmak, A., Njume, C. M., Borroni, B., & Ghidoni, R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073399 · Cited by 14 · see citing works
Wang, Y., Sun, X., He, B., & Yu, S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05073-3 · Cited by 14 · see citing works
Arbaciauskaite, S., Silvestri, S., Luo, P., Krüger, C., Mossmann, Z. J., Allelein, S., Scholz, A., Löffler, D., Fiorenza, S., Menale, A., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05719-w · Cited by 13 · see citing works
Hassan, A., Huang, Y., Mahjabina, Sudiro, O. H., Wang, X., He, J., Wei, Y., Liao, X., & Wang, G. (2024) · iMetaOmics. · doi:10.1002/imo2.33 · Cited by 12 · see citing works
Assessing Alzheimer's disease via plasma extracellular vesicle–derived mRNA
Pham, L. H. P., Chang, C., Tuchez, K., Liu, F., & Chen, Y. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70006 · Cited by 12 · see citing works
Cioanca, A. V., Wooff, Y., Aggio‐Bruce, R., Sekar, R., Dietrich, C. A., & Natoli, R. (2023) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12393 · Cited by 11 · see citing works
Ni, G., Kou, L., Duan, C.-Q., Meng, R., & Wang, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0306793 · Cited by 10 · see citing works
Exosomes as a Nanotheranostic Platform in Brain Diseases
Kudpaje, M., Joghee, S., & Kumar, R. M. R. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70215 · Cited by 10 · see citing works
Nahdi, S., Arafah, M., & Harrath, A. H. (2025) · Cells · doi:10.3390/cells14211693 · Cited by 10 · see citing works
Chen, Z., Shang, Y., Ou, Y., Shen, C., Cao, Y., Hu, H., Yang, R., Liu, T. H., Liu, Q., Song, M., et al. (2024) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2024.01.017 · Cited by 9 · see citing works
Cătană, C.-S., Marta, M. M., Văleanu, M., Dican, L., & Crișan, C. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158544 · Cited by 6 · see citing works
Pan, W., Teng, Y., Han, X., Liu, S., Pang, X., Wang, L., & Zhao, M. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100193 · Cited by 5 · see citing works
Sandau, U. S., Wiedrick, J. T., McFarland, T. J., Chen, S., Quinn, J. F., & Saugstad, J. A. (2025) · Scientific Reports · doi:10.1038/s41598-025-33589-0 · Cited by 4 · see citing works
Mesenchymal Stem Cells from Familial Alzheimer’s Patients Express MicroRNA Differently
Rochín-Hernández, L. J., Rochín‐Hernández, L. S., Padilla-Cristerna, M. L., Duarte-García, A., Jiménez-Acosta, M. A., Figueroa‐Corona, M. D. P., & Meraz‐Ríos, M. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031580 · Cited by 4 · see citing works
Xing, X., Liu, H., Zhang, M., & Li, Y. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1485750 · Cited by 4 · see citing works
Extracellular microRNAs modulate human microglial function through TLR8
Weidling, H., Motta, E., Kuhrt, L. D., Krüger, C., Figueiredo, C. A., Wallach, T., Frahm, S., Diecke, S., Wolf, S. A., Kettenmann, H., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1645062 · Cited by 3 · see citing works
Oriquat, G. A., Abdulsahib, W. K., Jyothi, S. R., Nayak, P. P., Chauhan, A. S., Singla, S., Sead, F. F., & Polatova, D. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05513-0 · Cited by 3 · see citing works
KLF12 transcriptional activation by a novel LncRNA A930015D03Rik enhances melanoma metastasis
Xiang, M., Li, Z., Su, J., Dai, X., Zhang, Y., Tan, J., Han, X., Xie, J., Tang, Y., Zhang, S., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.142686 · Cited by 2 · see citing works
Ma, P., Cui, H., Ren, L., Liu, Y., & Cen, M. (2026) · Apmis · doi:10.1111/apm.70148 · Cited by 2 · see citing works
Brain organoids as models of extracellular vesicle–mediated human neural communication
Rosa, G. L., Pascale, E., Iazzetta, M. R., Sozzi, E., Fico, A., Parrotta, E. I., & Fiorenzano, A. (2026) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-01806 · Cited by 2 · see citing works
ÇELİK, H., Dalkılınç, E., Aydın, Ş., Çelik, O., Küçükler, S., Topal, A., Akay, R., Gönüllü, S., Yıldız, M. O., Alım, B., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05889-7 · Cited by 2 · see citing works
MicroRNA cargo in neuron‐derived vesicles as peripheral biomarkers of brain insulin dysregulation
Cleary, J. A., Kumar, A., Su, Y., Singh, S., Hsu, F., Craft, S., Harrison, W., Keene, C. D., Howard, M. J., Hayden, K. M., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70597 · Cited by 1 · see citing works
Li, C., & Ochiya, T. (2026) · Cancers · doi:10.3390/cancers18081269 · Cited by 1 · see citing works
Guo, Y., Chen, P., Chen, S., Xu, N., Shi, J., Li, D., & Zhang, P. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05998-3 · Cited by 1 · see citing works
Extracellular Vesicles in Kidney Disease
Lv, C. (2023) · Physiology · doi:10.5772/intechopen.113200
Exosomes and extracellular vesicles for neurodegenerative diseases
Dutta, S., & Hornung, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28822-7.00008-8
Doi, K., Hirano, T., Tominaga, N., Watanabe, K., Oishi, K., Fukatsu-Chikumoto, A., Yamamoto, T., Ohteru, Y., Hamada, K., Murata, Y., et al. (2025) · Biomolecules · doi:10.3390/biom15121663
The role of miR-361-5p in delayed fracture healing and its clinical predictive value
Shang, Y., Cheng, Q., Wang, H., & Han, M. (2025) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2025-0256
Li, Y., Sun, C., & Liu, Q. (2026) · Neuropharmacology and Therapy · doi:10.15212/npt-2025-0007
Extracellular Vesicles in Hemostasis
Mostageer, M., Weber, V., & Eichhorn, T. (2026) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2026.02.013
Stevenson, G. C., Patil, M. S., & Grau, G. E. (2026) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2026.11
Adipose Tissue–Brain Crosstalk: The Role of Adipokines in the Regulation of Cognitive Function
Żołyniak, M., Soczyńska, J., Kania, K., Szwach, J., Kurowski, M., Gawełczyk, W., & Woźniak, S. (2026) · Obesities · doi:10.3390/obesities6030032
Circulating biochemical signatures of neurodegeneration in Alzheimer’s disease
Eliazer, G. R., & Kandasamy, M. (2026) · International review of neurobiology · doi:10.1016/bs.irn.2026.06.004
Extracellular Vesicle Translational Research
Hardenia, A., Zahiri, M., Afkhami, H., Bagheri, M. S., Reza, M. A. S., Yang, P., & Sheykhhasan, M. (2026) · Molecular and translational medicine · doi:10.1007/978-3-032-23810-8_13
Anwer, T., Verma, A., Asiri, A., Alaklobie, M., Albaqami, A., ALSHAHRANI, F., Aly, K., Sharma, M., Siddiqui, S., Alam, N., et al. (2026) · Journal of Molecular Neuroscience · doi:10.1007/s12031-026-02587-w
Nakahara, M., Kataoka, K., Maruyama, T., Nurhamim, M., Zhang, Y., Fukuhara, D., Uchida‐Fukuhara, Y., Islam, M. M., Morita, M., Saito, T., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177542
Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer’s Disease: A Systematic Review
Mocrei-Rebrean, Ș.-M., Răzniceanu, V., Pintilie, S. R., & Berindan‐Neagoe, I. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06198-9
Yang, J., Li, D., Chen, L., Li, S., & Yuan, X. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1873619
Benchohra, A., Juárez-Alia, C., Serrano‐Heras, G., Segura, T., Peinado, J. R., & Rabanal‐Ruiz, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219506
- Authors
- Li, W., & Zheng, Y.
- Affiliations
- Kunming University of Science and Technology (CN)
- Yunnan Agricultural University (CN)
- Corresponding author
- Zheng, Yun
- ORCID
- Zheng, Yun
- Venue
- Cells
- Publisher
- MDPI AG
- Published
- 2023-05-13
- Volume
- 12
- Issue
- 10
- Pages
- 1378
- ISSN
- 2073-4409 (ISSN-L)
- PMC
- PMC10216432
- OpenAlex
- W4382813296
- Semantic Scholar
- bdbf284804ad9a0d37ec765475b591d1e86e01db
- Cited by
- 43
- References
- 110
- Citations by year
- 2026: 17 · 2025: 12 · 2024: 11 · 2023: 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cells (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (31460295, SKLGE-2107)
- State Key Laboratory of Genetic Engineering, Fudan University, China (31460295, SKLGE-2107)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, microRNA, extracellular vesicles, miR-125b-5p, miR-132-3p, miR-9-5p, cerebrospinal fluid, biomarkers, diagnosis, therapeutic target, microRNA dysregulation, brain tissue
- MeSH terms
- Extracellular Vesicles, Alzheimer Disease, Animals, Humans, Neurodegenerative Diseases, MicroRNAs, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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