Cited by 107Neurological disorders and treatmentsTranscranial Magnetic Stimulation StudiesObsessive-Compulsive Spectrum Disorders

Closed-loop cortical neuromodulation in Parkinson’s disease: An alternative to deep brain stimulation?

Beuter, Anne, Lefaucheur, Jean-Pascal, Modolo, Julien·2014·Clinical Neurophysiology

Abstract

Deep brain stimulation (DBS) is usually performed to treat advanced Parkinson's disease (PD) patients with electrodes permanently implanted in basal ganglia while the stimulator delivers electrical impulses continuously and independently of any feedback (open-loop stimulation). Conversely, in closed-loop stimulation, electrical stimulation is delivered as a function of neuronal activities recorded and analyzed online. There is an emerging development of closed-loop DBS in the treatment of PD and a growing discussion about proposing cortical stimulation rather than DBS for this purpose. Why does it make sense to "close the loop" to treat parkinsonian symptoms? Could closed-loop stimulation applied to the cortex become a valuable therapeutic strategy for PD? Can mathematical modeling contribute to the development of this technique? We review the various evidences in favor of the use of closed-loop cortical stimulation for the treatment of advanced PD, as an emerging technique which might offer substantial clinical benefits for PD patients.

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Crossref · 10.1016/j.clinph.2014.01.006

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Authors
Beuter, A., Lefaucheur, J.-P., & Modolo, J.
Affiliations
  • Institut Polytechnique de Bordeaux (FR)
  • Université Paris-Est Créteil (FR)
  • Western University (CA)
Corresponding author
  • Beuter, Anne
  • Lefaucheur, Jean-Pascal
Venue
Clinical Neurophysiology
Publisher
Elsevier BV
Published
2014-05
Volume
125
Issue
5
Pages
874-885
ISSN
1388-2457 (ISSN-L)
OpenAlex
W1984309035
Cited by
107
References
197
Citations by year
2026: 2 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 7 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 14 · 2017: 10 · 2016: 14 · 2015: 15 · 2014: 3
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Keywords
Parkinson's disease, closed-loop stimulation, deep brain stimulation, open-loop stimulation, mathematical modeling, basal ganglia, neurofeedback
MeSH terms
Basal Ganglia, Electroencephalography, Equipment Design, Humans, Models, Neurological, Motor Cortex, Neurons, Parkinson Disease, Point-of-Care Systems, Prostheses and Implants, Feedback, Physiological, Deep Brain Stimulation

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