Cited by 344Neurological disorders and treatmentsObsessive-Compulsive Spectrum DisordersTranscranial Magnetic Stimulation Studies

Mechanisms of action of deep brain stimulation (DBS)

Montgomery, Erwin B., Gale, John T.·2008·Neuroscience & Biobehavioral Reviews

Abstract

Deep brain stimulation (DBS) is remarkably effective for a range of neurological and psychiatric disorders that have failed pharmacological and cell transplant therapies. Clinical investigations are underway for a variety of other conditions. Yet, the therapeutic mechanisms of action are unknown. In addition, DBS research demonstrates the need to re-consider many hypotheses regarding basal ganglia physiology and pathophysiology such as the notion that increased activity in the globus pallidus internal segment is causal to Parkinson's disease symptoms. Studies reveal a variety of apparently discrepant results. At the least, it is unclear which DBS effects are therapeutically effective. This systematic review attempts to organize current DBS research into a series of unifying themes or issues such as whether the therapeutic effects are local or systems-wide or whether the effects are related to inhibition or excitation. A number of alternative hypotheses are offered for consideration including suppression of abnormal activity, striping basal ganglia output of misinformation, reduction of abnormal stochastic resonance effects due to increased noise in the disease state, and reinforcement of dynamic modulation of neuronal activity by resonance effects.

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Crossref · 10.1016/j.neubiorev.2007.06.003

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Authors
Montgomery, E. B., & Gale, J. T.
Affiliations
  • University of Wisconsin–Madison (US)
  • Harvard University (US)
Corresponding author
Montgomery, Erwin B.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2008-01
Volume
32
Issue
3
Pages
388-407
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2143662434
Cited by
344
References
109
Citations by year
2026: 9 · 2025: 8 · 2024: 13 · 2023: 14 · 2022: 14 · 2021: 12 · 2020: 12 · 2019: 18 · 2018: 16 · 2017: 22 · 2016: 19 · 2015: 24 · 2014: 27 · 2013: 28 · 2012: 38
FWCI
2.03
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Center for Research Resources (C06RR020141, RR 15459-01, C06RR015459, RR 020141-01, P51RR000167)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
deep brain stimulation, mechanism of action, basal ganglia, Parkinson's disease, globus pallidus internus, therapeutic effects, stochastic resonance, basal ganglia output, neuropsychiatric disorders
MeSH terms
Basal Ganglia, Humans, Neural Inhibition, Neural Pathways, Synaptic Transmission, Neurons, Parkinson Disease, Deep Brain Stimulation

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