The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors

The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707442 · Cited by 1,953 · see citing works

Neonatal Brain Injury

Ferriero, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041996 · Cited by 1,148 · see citing works

Cannabidiol and (−)Δ ⁹ -tetrahydrocannabinol are neuroprotective antioxidants

Hampson, A. J., Grimaldi, M., Axelrod, J., & Wink, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.14.8268 · Cited by 850 · see citing works

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma

Ligresti, A., Moriello, A. S., Starowicz, K., Matias, I., Pisanti, S., PETROCELLIS, L. D., Laezza, C., Portella, G., Bifulco, M., & Marzo, V. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.105247 · Cited by 569 · see citing works

Cannabidiol—recent advances

Mechoulam, R., Peters, M., Murillo‐Rodriguez, E., & Hanuš, L. O. (2007) · Chemistry & Biodiversity · doi:10.1002/cbdv.200790147 · Cited by 515 · see citing works

Adenosine inhibits IL‐12 and TNF‐α production via adenosine A 2a receptor‐dependent and independent mechanisms

Haskó, G., Kuhel, D. G., Chen, J., Schwarzschild, M. A., Deitch, E. A., Mabley, J. G., Marton, A., & Szabó, C. (2000) · The FASEB Journal · doi:10.1096/fj.99-0508com · Cited by 512 · see citing works

Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression

Carrier, E. J., Auchampach, J. A., & Hillard, C. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511232103 · Cited by 497 · see citing works

The Cannabinoid CB2 Receptor as a Target for Inflammation-Dependent Neurodegeneration

Ashton, J. C., & Glass, M. (2007) · Current Neuropharmacology · doi:10.2174/157015907780866884 · Cited by 336 · see citing works

Adenosine and Brain Ischemia

Rudolphi, K. A., & Schubert, P. (1995) · Springer eBooks · doi:10.1007/978-1-4615-2011-5_43 · Cited by 296 · see citing works

Adenosine: does it have a neuroprotective role after all?

de Mendonça, A., Sebastião, A. M., & Ribeiro, J. A. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00033-3 · Cited by 248 · see citing works

Adenosine A2A receptors and brain injury: Broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation

Chen, J., Sonsalla, P. K., Pedata, F., Melani, A., Domenici, M. R., Popoli, P., Geiger, J. D., Lopes, L. V., & de Mendonça, A. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.09.002 · Cited by 238 · see citing works

Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in β-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-κB involvement

Esposito, G., De Filippis, D., Maiuri, M. C., De Stefano, D., Carnuccio, R., & Iuvone, T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.01.047 · Cited by 225 · see citing works

Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine 1A Receptor–Dependent Mechanism

Mishima, K., Hayakawa, K., Abe, K., Ikeda, T., Egashira, N., Iwasaki, K., & Fujiwara, M. (2005) · Stroke · doi:10.1161/01.str.0000163083.59201.34 · Cited by 225 · see citing works

Prenatal exposure to a cannabinoid agonist produces memory deficits linked to dysfunction in hippocampal long-term potentiation and glutamate release

Mereu, G., Fà, M., Ferraro, L., Cagiano, R., Antonelli, T., Tattoli, M., Ghiglieri, V., Tanganelli, S., Gessa, G. L., & Cuomo, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0537849100 · Cited by 213 · see citing works

Critical Role of Angiotensin II in Excess Salt-Induced Brain Oxidative Stress of Stroke-Prone Spontaneously Hypertensive Rats

Kim‐Mitsuyama, S., Yamamoto, E., Tanaka, T., Zhan, Y., Izumi, Y., Izumiya, Y., Ioroi, T., Wanibuchi, H., & Iwao, H. (2005) · Stroke · doi:10.1161/01.str.0000163084.16505.e3 · Cited by 173 · see citing works

Cannabinoid CB 2 Receptor Activation Decreases Cerebral Infarction in a Mouse Focal Ischemia/Reperfusion Model

Zhang, M., Martin, B. R., Adler, M. W., Razdan, R. K., Jallo, J., & Tuma, R. F. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600447 · Cited by 165 · see citing works

Glutamate release from astrocytes in physiological conditions and in neurodegenerative disorders characterized by neuroinflammation.

Vesce, S., Rossi, D., Brambilla, L., & Volterra, A. (2007) · International review of neurobiology · doi:10.1016/s0074-7742(07)82003-4 · Cited by 159 · see citing works

Neuroprotective Effects of the Nonpsychoactive Cannabinoid Cannabidiol in Hypoxic-Ischemic Newborn Piglets

Alvarez, F. J., Lafuente, H., Rey-Santano, M. C., Mielgo, V., Gastiasoro, E., Rueda, M. A., Pertwee, R. G., Castillo, A. I., Romero, J., & Martínez-Orgado, J. A. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318186e5dd · Cited by 151 · see citing works

Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide‐induced nitric oxide release in astrocyte cultures

Molina‐Holgado, F., Molina‐Holgado, E., Guaza, C., & Rothwell, N. J. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10165 · Cited by 148 · see citing works

Cannabidiol reduced the striatal atrophy caused 3‐nitropropionic acid<i>in vivo</i>by mechanisms independent of the activation of cannabinoid, vanilloid TRPV₁and adenosine A_2Areceptors

Sagredo, O., Ramos, J. A., Decio, A., Mechoulam, R., & Fernández‐Ruiz, J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05717.x · Cited by 147 · see citing works

Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain

Ashton, J. C., Rahman, R. M. A., Nair, S. M., Sutherland, B. A., Glass, M., & Appleton, I. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.10.053 · Cited by 131 · see citing works

The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro

Sacerdote, P., Martucci, C., Vaccani, A., Bariselli, F., Panerai, A. E., Colombo, A., Parolaro, D., & Massi, P. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.10.003 · Cited by 126 · see citing works

Neonatal cerebral hypoxia-ischemia: The effect of adenosine receptor antagonists

Bona, E., Ådén, U., Gilland, E., Fredholm, B. B., & Hagberg, H. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00139-1 · Cited by 119 · see citing works

Caspases on the brain

Troy, C. M., & Salvesen, G. S. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10294 · Cited by 107 · see citing works

Characterization of the Neuroprotective Effect of the Cannabinoid Agonist WIN-55212 in an In Vitro Model of Hypoxic-Ischemic Brain Damage in Newborn Rats

Fernández‐López, D., Martínez-Orgado, J. A., Núñez, E., et al. (2006) · Pediatric Research · doi:10.1203/01.pdr.0000228839.00122.6c · Cited by 104 · see citing works

Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism

Hayakawa, K., Mishima, K., Irie, K., Hazekawa, M., Mishima, S., Fujioka, M., Orito, K., Egashira, N., Katsurabayashi, S., Takasaki, K., et al. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.040 · Cited by 100 · see citing works

Aggravated Brain Damage After Hypoxic Ischemia in Immature Adenosine A 2A Knockout Mice

Ådén, U., Halldner, L., Lagercrantz, H., Dalmau, I., Ledent, C. A., & Fredholm, B. B. (2003) · Stroke · doi:10.1161/01.str.0000060204.67672.8b · Cited by 96 · see citing works

S -nitrosylation/activation of COX-2 mediates NMDA neurotoxicity

Tian, J., Kim, S. F., Hester, L. D., & Snyder, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804852105 · Cited by 95 · see citing works

The Pharmacology and Therapeutic Potential of Plant Cannabinoids

Cascio, M. G., Pertwee, R. G., & Marini, P. (2017) · Springer eBooks · doi:10.1007/978-3-319-54564-6_9 · Cited by 88 · see citing works

Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor‐independent myeloperoxidase‐inhibiting mechanism

Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Irie, K., Fujioka, M., Orito, K., Abe, K., Hasebe, N., Egashira, N., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04565.x · Cited by 84 · see citing works

Effects of the Adenosine A2A Receptor Antagonist SCH 58621 on Cyclooxygenase-2 Expression, Glial Activation, and Brain-Derived Neurotrophic Factor Availability in a Rat Model of Striatal Neurodegeneration

Minghetti, L., Greco, A., Potenza, R. L., Pèzzola, A., Blum, D. L., Bantubungi, K., & Popoli, P. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3180517477 · Cited by 81 · see citing works

The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats

Fernández‐López, D., Pazos, M. R., Tolón, R. M., Moro, M. Á., Romero, J., Lizasoaín, I., & Martínez-Orgado, J. A. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e318123fbb8 · Cited by 74 · see citing works

Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils

Braida, D., Pegorini, S., Arcidiacono, M. V., Consalez, G. G., Croci, L., & Sala, M. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00569-x · Cited by 73 · see citing works

A3 Adenosine Receptor: Pharmacology and Role in Disease

Borea, P. A., Gessi, S., Bar‐Yehuda, S., & Fishman, P. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-89615-9_10 · Cited by 59 · see citing works

The Seek of Neuroprotection: Introducing Cannabinoids

Martínez-Orgado, J. A., Fernández‐López, D., Lizasoaín, I., et al. (2007) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488907780832724 · Cited by 49 · see citing works

Adenosine A1 receptor agonism in the immature rat brain and heart

Ådén, U., Leverin, A., Hagberg, H., & Fredholm, B. B. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01220-1 · Cited by 46 · see citing works

Immature rat brain slices exposed to oxygen–glucose deprivation as an in vitro model of neonatal hypoxic–ischemic encephalopathy

Fernández‐López, D., Martínez-Orgado, J. A., Casanova, I., et al. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.01.005 · Cited by 37 · see citing works

Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells

Lee, J.-K., Won, J., Singh, A. K., et al. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.09.006 · Cited by 14 · see citing works

Changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids

Turkanis, S. A., & Karler, R. (1988) · Neuropharmacology · doi:10.1016/0028-3908(88)90083-4 · Cited by 12 · see citing works

Nitric Oxide Synthase as a Target for the Prevention of Hypoxic-Ischemic Newborn Brain Damage

Martínez-Orgado, J. A., Fernández‐López, D., Moro, M. Á., et al. (2006) · Current Enzyme Inhibition · doi:10.2174/157340806777934784 · Cited by 10 · see citing works

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

Devinsky, O., Cilio, M. R., Cross, H., Fernandez‐Ruiz, J., French, J., Hill, C., Katz, R., Di Marzo, V., Jutras‐Aswad, D., Notcutt, W. G., et al. (2014) · Epilepsia · doi:10.1111/epi.12631 · Cited by 1,000 · see citing works

Cannabinoids and the expanded endocannabinoid system in neurological disorders

Cristino, L., Bisogno, T., & Di Marzo, V. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0284-z · Cited by 970 · see citing works

Safety and side effects of cannabidiol, a Cannabis sativa constituent

Machado Bergamaschi, M., Helena Costa Queiroz, R., Waldo Zuardi, A., & Alexandre S. Crippa, J. (2011) · Current Drug Safety · doi:10.2174/157488611798280924 · Cited by 558 · see citing works

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

Esposito, G., Scuderi, C., Valenza, M., Togna, G. I., Latina, V., De Filippis, D., Cipriano, M., Carratù, M. R., Iuvone, T., & Steardo, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028668 · Cited by 410 · see citing works

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

Campos, A. C., Ortega, Z., Palazuelos, J., Fogaça, M. V., Aguiar, D. C., Díaz-Alonso, J., Ortega-Gutiérrez, S., Vázquez-Villa, H., Moreira, F. A., Guzmán, M., et al. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001502 · Cited by 313 · see citing works

Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age

Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02009 · Cited by 308 · see citing works

Plastic and neuroprotective mechanisms involved in the therapeutic effects of cannabidiol in psychiatric disorders

Campos, A. C., Fogaça, M. V., Scarante, F. F., Joca, S. R. L., Sales, A. J., Gomes, F. V., Sonego, A. B., Rodrigues, N. S., Galve-Roperh, I., & Guimarães, F. S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00269 · Cited by 175 · see citing works

Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection

da Silva, V. K., de Freitas, B. S., da Silva Dornelles, A., Nery, L. R., Falavigna, L., Ferreira, R. D. P., Bogo, M. R., Hallak, J. E. C., Zuardi, A. W., Crippa, J. A. S., et al. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8514-7 · Cited by 91 · see citing works

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

Fagherazzi, E. V., Garcia, V. A., Maurmann, N., Bervanger, T., Halmenschlager, L. H., Busato, S. B., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Schröder, N. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2449-3 · Cited by 87 · see citing works

Contrasting protective effects of cannabinoids against oxidative stress and amyloid-β evoked neurotoxicity in vitro

Harvey, B. S., Ohlsson, K. S., Mååg, J. L. V., Musgrave, I. F., & Smid, S. D. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.12.015 · Cited by 82 · see citing works

Cannabidiol post-treatment alleviates rat epileptic-related behaviors and activates hippocampal cell autophagy pathway along with antioxidant defense in chronic phase of pilocarpine-induced seizure

Hosseinzadeh, M., Nikseresht, S., Khodagholi, F., Naderi, N., & Maghsoudi, N. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0703-6 · Cited by 61 · see citing works

(+)-Cannabidiol analogues which bind cannabinoid receptors but exert peripheral activity only

Fride, E., Feigin, C., Ponde, D. E., Breuer, A., Hanuš, L., Arshavsky, N., & Mechoulam, R. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.10.049 · Cited by 62 · see citing works

Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis

Morgan, C. J. A., & Curran, H. V. (2008) · British Journal of Psychiatry · doi:10.1192/bjp.bp.107.046649 · Cited by 300 · see citing works

Cannabinoid Ligand-Receptor Signaling During Early Pregnancy in the Mouse

Paria, B. C., Das, S., & Dey, S. K. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-710-9_40 · Cited by 3 · see citing works

The effect of delta-9-tetrahydrocannabinol and cannabidiol on p50 of the oxygen haemoglobin dissociation curve

James, T. R., Watson, C. T., & Pepple, D. J. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104539 · Cited by 2 · see citing works

New Cannabidiol Derivatives: Synthesis, Binding to Cannabinoid Receptor, and Evaluation of Their Antiinflammatory Activity

Ben‐Shabat, S., Hanuš, L. O., Katzavian, G., & Gallily, R. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm050709m · Cited by 106 · see citing works