Cited by 87Cannabis and Cannabinoid ResearchAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

Fagherazzi, Elen V., Garcia, Vanessa A., Maurmann, Natasha, Bervanger, Thielly, Halmenschlager, Luis H., Busato, Stefano B., Hallak, Jaime E., Zuardi, Antônio W. +2 more·2012·Psychopharmacology

Abstract

Rationale Cannabidiol, the main nonpsychotropic constituent of Cannabis sativa, possesses a large number of pharmacological effects including anticonvulsive, sedative, hypnotic, anxiolytic, antipsychotic, anti-inflammatory, and neuroprotective, as demonstrated in clinical and preclinical studies. Many neurodegenerative disorders involve cognitive deficits, and this has led to interest in whether cannabidiol could be useful in the treatment of memory impairment associated to these diseases.Objectives We used an animal model of cognitive impairment induced by iron overload in order to test the effects of cannabidiol in memory-impaired rats.Methods Rats received vehicle or iron at postnatal days 12-14. At the age of 2 months, they received an acute intraperitoneal injection of vehicle or cannabidiol (5.0 or 10.0 mg/kg) immediately after the training session of the novel object recognition task. In order to investigate the effects of chronic cannabidiol, iron-treated rats received daily intraperitoneal injections of cannabidiol for 14 days. Twenty-four hours after the last injection, they were submitted to object recognition training. Retention tests were performed 24 h after training.Results A single acute injection of cannabidiol at the highest dose was able to recover memory in iron-treated rats. Chronic cannabidiol improved recognition memory in iron-treated rats. Acute or chronic cannabidiol does not affect memory in control rats.Conclusions The present findings provide evidence suggesting the potential use of cannabidiol for the treatment of cognitive decline associated with neurodegenerative disorders. Further studies, including clinical trials, are warranted to determine the usefulness of cannabidiol in humans suffering from neurodegenerative disorders.

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Crossref · 10.1007/s00213-011-2449-3

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Authors
Fagherazzi, E. V., Garcia, V. A., Maurmann, N., Bervanger, T., Halmenschlager, L. H., Busato, S. B., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Schröder, N.
Affiliations
  • Pontifícia Universidade Católica do Rio Grande do Sul (BR)
  • Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (BR)
  • Universidade de São Paulo (BR)
Corresponding author
Schröder, Nadja
Venue
Psychopharmacology
Published
2011-08-26
Volume
219
Issue
4
Pages
1133-1140
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2043268426
Cited by
87
References
33
Citations by year
2026: 2 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 1 · 2021: 6 · 2020: 5 · 2019: 12 · 2018: 11 · 2017: 7 · 2016: 5 · 2015: 9 · 2014: 1 · 2013: 4 · 2012: 3
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
cannabidiol, memory impairment, cognitive impairment, iron overload, neurodegenerative diseases, recognition memory, novel object recognition, neuroprotection
MeSH terms
Animals, Cannabidiol, Cognition Disorders, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Male, Memory Disorders, Rats, Wistar, Iron Overload, Neurodegenerative Diseases, Rats

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