Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex
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Preclinical and clinical studies show that cannabis modulates mood and possesses antidepressant-like properties, mediated by the agonistic activity of cannabinoids on central CB 1 receptors (CB 1 Rs). The action of CB 1 R agonists on the serotonin (5-HT) system, the major transmitter system involved in mood control and implicated in the mechanism of action of antidepressants, remains however poorly understood. In this study, we demonstrated that, at low doses, the CB 1 R agonist WIN55,212-2 [R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate] exerts potent antidepressant-like properties in the rat forced-swim test (FST). This effect is CB 1 R dependent because it was blocked by the CB 1 R antagonist rimonabant and is 5-HT mediated because it was abolished by pretreatment with the 5-HT-depleting agent parachlorophenylalanine. Then, using in vivo electrophysiology, we showed that low doses of WIN55,212-2 dose dependently enhanced dorsal raphe nucleus 5-HT neuronal activity through a CB 1 R-dependent mechanism. Conversely, high doses of WIN55,212-2 were ineffective in the FST and decreased 5-HT neuronal activity through a CB 1 R-independent mechanism. The CB 1 R agonist-induced enhancement of 5-HT neuronal activity was abolished by total or medial prefrontocortical, but not by lateral prefrontocortical, transection. Furthermore, 5-HT neuronal activity was enhanced by the local microinjection of WIN55,212-2 into the ventromedial prefrontal cortex (mPFCv) but not by the local microinjection of WIN55,212-2 into the lateral prefrontal cortex. Similarly, the microinjection of WIN55,212-2 into the mPFCv produced a CB 1 R-dependent antidepressant-like effect in the FST. These results demonstrate that CB 1 R agonists possess antidepressant-like properties and modulate 5-HT neuronal activity via the mPFCv.
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The finding that circulating AEA is negatively associated with baseline Anxiety is in agreement with a clinical study and with findings in nonhuman models.
“This is in agreement with a clinical study (Hill et al, 2008) as well as with findings in nonhuman models, in which inhibition of AEA metabolism has anxiolytic and antidepressant effects (Bambico et al, 2007;Naidu et al, 2007).”
From Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans (2012) · cites this paper as Bambico et al, 2007
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works
The molecular logic of endocannabinoid signalling
Piomelli, D. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1247 · Cited by 1,957 · see citing works
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586 · see citing works
Cryan, J. F., Valentino, R. J., & Lucki, I. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.008 · Cited by 1,115 · see citing works
Marsicano, G., & Lutz, B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00847.x · Cited by 937 · see citing works
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931 · see citing works
Lucki, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00010 · Cited by 803 · see citing works
Iversen, L. L. (2003) · Brain · doi:10.1093/brain/awg143 · Cited by 735 · see citing works
Gobbi, G., Bambico, F. R., Mangieri, R. A., Bortolato, M., Campolongo, P., Solinas, M., Cassano, T., Morgese, M. G., Debonnel, G., Duranti, A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509591102 · Cited by 676 · see citing works
Self-citation“Behavioural despair” in rats and mice: Strain differences and the effects of imipramine
Porsolt, R. D., Bertin, A., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90414-4 · Cited by 640 · see citing works
Jiang, W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25509 · Cited by 527 · see citing works
Peyron, C., Petit, J.-M., Rampon, C., Jouvet, M., & Luppi, P. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00268-6 · Cited by 509 · see citing works
Involvement of CB1 cannabinoid receptors in emotional behaviour
Martín, M., Ledent, C. A., Parmentier, M., Maldonado, R. J., & Valverde, O. (2002) · Psychopharmacology · doi:10.1007/s00213-001-0946-5 · Cited by 507 · see citing works
Endocannabinoid system and stress and anxiety responses
VIVEROS, M., MARCO, E., & FILE, S. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.01.029 · Cited by 485 · see citing works
Huestis, M. A., Gorelick, D. A., Heishman, S. J., Preston, K. L., Nelson, R. A., Moolchan, E. T., & Frank, R. A. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.322 · Cited by 479 · see citing works
Melis, M., Pistis, M., Perra, S., Muntoni, A. L., Pillolla, G., & Gessa, G. L. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4503-03.2004 · Cited by 478 · see citing works
Izquierdo, A., Wellman, C. L., & Holmes, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0474-06.2006 · Cited by 459 · see citing works
Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists
Baraban, J. M., & Aghajanian, G. K. (1980) · Neuropharmacology · doi:10.1016/0028-3908(80)90187-2 · Cited by 442 · see citing works
Page, M. E., Detke, M. J., Dalvi, A., Kirby, L. G., & Lucki, I. (1999) · Psychopharmacology · doi:10.1007/s002130051156 · Cited by 385 · see citing works
Descarries, L., Watkins, K. C., Garcia, S., & Beaudet, A. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902070305 · Cited by 380 · see citing works
Hill, M. N., Patel, S., Carrier, E. J., Rademacher, D. J., Ormerod, B. K., Hillard, C. J., & Gorzalka, B. B. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300601 · Cited by 363 · see citing works
Marsch, R., Foeller, E., Rammes, G., Bunck, M., Kössl, M., Holsboer, F., Zieglgänsberger, W., Landgraf, R., Lutz, B., & Wotjak, C. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3303-06.2007 · Cited by 359 · see citing works
The effects of genetic and pharmacological blockade of the CB1 cannabinoid receptor on anxiety
Haller, J., Bakos, N., Szirmay, M., Ledent, C., & Freund, T. F. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02192.x · Cited by 354 · see citing works
Bortolato, M., Mangieri, R. A., Fu, J., Kim, J. H., Arguello, O., Duranti, A., Tontini, A., Mor, M., Tarzia, G., & Piomelli, D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.12.001 · Cited by 347 · see citing works
Egertová, M., Cravatt, B. F., & Elphick, M. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00145-3 · Cited by 347 · see citing works
Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study☆
Moldrich, G., & Wenger, T. (2000) · Peptides · doi:10.1016/s0196-9781(00)00324-7 · Cited by 335 · see citing works
Egertová, M., Giang, D. K., Cravatt, B. F., & Elphick, M. R. (1998) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1998.0543 · Cited by 333 · see citing works
Behavioral Effects of Cannabinoid Agents in Animals
Chaperon, F., & Thiébot, M.-H. (1999) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v13.i3.20 · Cited by 311 · see citing works
Navarro, M., Hernández, E., Muñoz, R. M., del Arco, I., Villanúa, M. Á., Carrera, M. R. A., & de Fonseca, F. R. (1997) · Neuroreport · doi:10.1097/00001756-199701200-00023 · Cited by 306 · see citing works
Maione, S., Bisogno, T., de Novellis, V., Palazzo, E., Cristino, L., Valenti, M., Petrosino, S., Guglielmotti, V., Rossi, F., & Marzo, V. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093286 · Cited by 293 · see citing works
Díaz-Mataix, L., Scorza, M. C., Bortolozzi, A. A., Tóth, M., Celada, P., & Artigas, F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2999-05.2005 · Cited by 288 · see citing works
Haller, J., Varga, B., Ledent, C., Barna, I., & Freund, T. F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03293.x · Cited by 284 · see citing works
Blier, P. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00036-6 · Cited by 282 · see citing works
Amat, J., Paul, E., Zarza, C., Watkins, L. R., & Maier, S. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3630-06.2006 · Cited by 249 · see citing works
The medicinal use of cannabis in the UK: results of a nationwide survey
Ware, M. A., Adams, H., & Guy, G. W. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2004.00271.x · Cited by 239 · see citing works
Hill, M. N., & Gorzalka, B. B. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.03.003 · Cited by 231 · see citing works
Behavioral control, the medial prefrontal cortex, and resilience
Maier, S. F., Amat, J., Baratta, M. V., Paul, E. D., & Watkins, L. R. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/smaier · Cited by 231 · see citing works
Riegel, A. C., & Lupica, C. R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3695-04.2004 · Cited by 227 · see citing works
Hungund, B. L., Vinod, K. Y., Kassir, S. A., Basavarajappa, B. S., Yalamanchili, R., Cooper, T. B., Mann, J. J., & Arango, V. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001376 · Cited by 226 · see citing works
Pistis, M., Ferraro, L., Pira, L., Flore, G., Tanganelli, S., Gessa, G. L., & Devoto, P. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03055-x · Cited by 226 · see citing works
Hajós, M., Hajós‐Korcsok, É., & Sharp, T. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702510 · Cited by 210 · see citing works
Sairanen, M., O’Leary, O. F., Knuuttila, J. E., & Castrén, E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.069 · Cited by 206 · see citing works
Hájos, N., & Freund, T. F. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00157-0 · Cited by 198 · see citing works
Allers, K. A., & Sharp, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00518-9 · Cited by 188 · see citing works
Jankowski, M. P., & Sesack, S. R. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.10976 · Cited by 186 · see citing works
Shearman, L. P., Rosko, K., Fleischer, R., Wang, J., Xu, S., Tong, X., & Rocha, B. A. G. (2003) · Behavioural Pharmacology · doi:10.1097/00008877-200312000-00001 · Cited by 186 · see citing works
Posttraumatic Stress Disorder: Clinical Features, Pathophysiology, and Treatment
Vieweg, W. V. R., Julius, D. A., Fernandez, A., Beatty-Brooks, M., Hettema, J. M., & Pandurangi, A. K. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.09.027 · Cited by 186 · see citing works
Identification of the cannabinoid receptor type 1 in serotonergic cells of raphe nuclei in mice
Häring, M., Marsicano, G., Lutz, B., & Monory, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.021 · Cited by 171 · see citing works
Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
Diana, M., Melis, M., & Gessa, G. L. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00292.x · Cited by 152 · see citing works
Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes.
Banerjee, S., Snyder, S. H., & Mechoulam, R. (1975) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30230-2 · Cited by 146 · see citing works
Liapi, A., & Wood, J. N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04270.x · Cited by 142 · see citing works
Haj‐Dahmane, S., & Shen, R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3258-04.2005 · Cited by 136 · see citing works
Barna, I., Zelena, D., Arszovszki, A. C., & Ledent, C. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.06.006 · Cited by 136 · see citing works
Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
Ashton, C. H., Moore, P. B., Gallagher, P., & Young, A. H. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105051541 · Cited by 132 · see citing works
Increase in meso‐prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids
Diana, M., Melis, M., & Gessa, G. L. (1998) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1998.00292.x · Cited by 129 · see citing works
Pistis, M., Perra, S., Pillolla, G., Melis, M., Gessa, G., & Muntoni, A. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2003.08.003 · Cited by 124 · see citing works
Muntoni, A. L., Pillolla, G., Melis, M., Perra, S., Gessa, G. L., & Pistis, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04759.x · Cited by 119 · see citing works
Cannabinoid Modulation of Opiate Reinforcement through the Ventral Striatopallidal Pathway
Caillé, S., & Parsons, L. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300848 · Cited by 118 · see citing works
Juckel, G. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00097-9 · Cited by 113 · see citing works
Gartside, S. E., Hajós‐Korcsok, É., Bagdy, E., Hársing, L. G., Sharp, T., & Hajós, M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00060-9 · Cited by 109 · see citing works
Altered responsiveness of serotonin receptor subtypes following long-term cannabinoid treatment
Hill, M. N., Sun, J. C., Tse, M., & Gorzalka, B. B. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005651 · Cited by 98 · see citing works
Volkow, N. D., Gillespie, H. K., Mullani, N. A., Tancredi, L., Grant, C., Ivanović, M., & Hollister, L. E. (1991) · Psychiatry Research Neuroimaging · doi:10.1016/0925-4927(91)90030-t · Cited by 91 · see citing works
Effects of cannabinoids on prefrontal neuronal responses to ventral tegmental area stimulation
Pistis, M., Porcu, G. S., Melis, M., Diana, M., & Gessa, G. L. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01612.x · Cited by 91 · see citing works
Mathew, R. J., Wilson, W. H., Turkington, T. G., Hawk, T. C., Coleman, R. E., DeGrado, T. R., & Provenzale, J. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00069-0 · Cited by 91 · see citing works
Trettel, J., & Levine, E. S. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.1.534 · Cited by 79 · see citing works
Fortin, D. A., Trettel, J., & Levine, E. S. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00351.2004 · Cited by 76 · see citing works
Deroche‐Gamonet, V., Moal, M. L., Piazza, P. V., & Soubrié, P. (2001) · Psychopharmacology · doi:10.1007/s002130100804 · Cited by 72 · see citing works
Localization of GABAB receptors in midbrain monoamine containing neurons in the rat
Wirtshafter, D., & Sheppard, A. C. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00487-7 · Cited by 70 · see citing works
Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function
Gobbi, G., Cassano, T., Radja, F., Morgese, M. G., Cuomo, V., SANTARELLI, L., Hen, R., & Blier, P. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.07.004 · Cited by 62 · see citing works
Self-citationHaddjeri, N. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00138-4 · Cited by 50 · see citing works
Cannabinoid receptor agonist WIN 55,212‐2 inhibits rat cortical dialysate γ‐aminobutyric acid levels
Ferraro, L., Tomasini, M. C., Cassano, T., Bebe, B. W., Siniscalchi, A., O'Connor, W. T., Magee, P. J., Tanganelli, S., Cuomo, V., & Antonelli, T. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1224 · Cited by 48 · see citing works
Ashton, H., Golding, J. B., Marsh, V. R., Millman, J. E., & Thompson, J. (1981) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1981.tb01294.x · Cited by 42 · see citing works
TRP's: Links to schizophrenia?
Chahl, L. A. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.05.003 · Cited by 35 · see citing works
Johnson, K. M., HO, B. T., & Dewey, W. L. (1976) · Life Sciences · doi:10.1016/0024-3205(76)90038-2 · Cited by 28 · see citing works
Tomasini, M. C., Ferraro, L., Bebe, B. W., Tanganelli, S., Cassano, T., Cuomo, V., & Antonelli, T. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10242 · Cited by 25 · see citing works
Bronander, K. A., & Bloch, M. J. (2007) · Vascular Health and Risk Management · doi:10.2147/vhrm.2007.3.2.181 · Cited by 9 · see citing works
Volkow, N. D. (1991) · Psychiatry Research · doi:10.1016/0165-1781(91)90146-g · Cited by 7 · see citing works
Fadda, P., Scherma, M., Salis, P., Mascia, P., Fattore, L., & Fratta, W. (2006) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(06)70611-3 · Cited by 1 · see citing works
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- Fadda P, Scherma M, Salis P, Mascia P, Fattore L, Fratta W (2006) Involve- ment of the 5-HT 1A serotonergic receptors in the anxiety-like effects in- duced by the CB 1 receptor agonist WIN55,212-2. International Cannabi- noid Research Society, 16th Annual Symposium on the Cannabinoids, Tihany, Hungary, June 24 -28.
Cited by
Sorted by citations
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works
Self-citationThe neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works
Gregorio, D. D., McLaughlin, R. J., Posa, L., Ochoa‐Sanchez, R., Enns, J. P., López-Canul, M., Aboud, M. K., Maione, S., Comai, S., & Gobbi, G. (2018) · Pain · doi:10.1097/j.pain.0000000000001386 · Cited by 402 · see citing works
Self-citationNutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions
Lafourcade, M., Larrieu, T., Mato, S., Duffaud, A. M., Sepers, M. D., Matias, I., Smedt, V. D., Labrousse, V. F., Brétillon, L., Matute, C., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2736 · Cited by 314 · see citing works
Linge, R., Jiménez-Sánchez, L., Campa, L., Pilar-Cuéllar, F., Vidal, R., Pazos, Á., Adell, A., & Díaz, Á. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.017 · Cited by 285 · see citing works
Best Practice & Research Clinical Endocrinology & Metabolism
Grieb, M. (2009) · Cited by 276 · see citing works
Moreira, F. A., Grieb, M., & Lutz, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.003 · Cited by 272 · see citing works
Finberg, J. P. M. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.010 · Cited by 263 · see citing works
Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans
Dlugos, A., Childs, E., Stuhr, K. L., Hillard, C. J., & de Wit, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.100 · Cited by 248 · see citing works
Hill, M. N., Carrier, E. J., McLaughlin, R. J., Morrish, A. C., Meier, S. E., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05567.x · Cited by 246 · see citing works
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain
Callén, L., Moreno, E., Barroso‐Chinea, P., Moreno‐Delgado, D., Cortés, A., Mallol, J., Casadó, V., Lanciego, J. L., Franco, R., Lluís, C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.335273 · Cited by 239 · see citing works
The endocannabinoid system in anxiety, fear memory and habituation
Ruehle, S., Rey, A. A., Remmers, F., & Lutz, B. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408958 · Cited by 236 · see citing works
Shen, C.-J., Zheng, D., Li, K., Yang, J., Pan, H., Yu, X.-D., Fu, J., Zhu, Y., Sun, Q.-X., Tang, M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0299-9 · Cited by 223 · see citing works
Endocannabinoid system and mood disorders: Priming a target for new therapies
Micale, V., Marzo, V. D., Šulcová, A., Wotjak, C. T., & Drago, F. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.002 · Cited by 222 · see citing works
The endocannabinoid system: emotion, learning and addiction
Moreira, F. A., & Lutz, B. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00104.x · Cited by 222 · see citing works
Baron, E. P. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12570 · Cited by 205 · see citing works
Clinical applications of hallucinogens: a review
Garcia-Romeu, A., Kersgaard, B., & Addy, P. H. (2016) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000084 · Cited by 201 · see citing works
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 180 · see citing works
Hill, M. N., Hillard, C. J., Bambico, F. R., Patel, S., Gorzalka, B. B., & Gobbi, G. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.006 · Cited by 172 · see citing works
Self-citationRole of the endocannabinoid system in regulation of the hypothalamic-pituitary-adrenocortical axis
Steiner, M. S., & Wotjak, C. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00433-0 · Cited by 167 · see citing works
Ma, H., Li, C., Wang, J., Zhang, X., Li, M., Zhang, R., Huang, Z., & Zhang, Y. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019409118 · Cited by 158 · see citing works
Bambico, F. R., Nguyen, N.-T., Katz, N., & Gobbi, G. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.020 · Cited by 161 · see citing works
Self-citationDepression-like phenotype following chronic CB1 receptor antagonism
Beyer, C. E., Dwyer, J. M., Piesla, M. J., Platt, B. J., Shen, R., Rahman, Z., Chan, K., Manners, M. T., Samad, T. A., Kennedy, J. D., et al. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.020 · Cited by 160 · see citing works
Sartim, A. G., Guimarães, F. S., & Joca, S. R. L. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.01.033 · Cited by 156 · see citing works
CB1 receptor-deficient mice as a model for depression
Valverde, O., & Torrens, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.031 · Cited by 153 · see citing works
The endocannabinoid system and psychiatric disorders
Parolaro, D., Realini, N., Viganò, D., Guidali, C., & Rubino, T. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.018 · Cited by 150 · see citing works
Braida, D., Capurro, V., Zani, A. D., Rubino, T., Viganò, D., Parolaro, D., & Sala, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00230.x · Cited by 141 · see citing works
Bambico, F. R., Cassano, T., Domínguez-López, S., Katz, N., Walker, C. D., Piomelli, D., & Gobbi, G. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.80 · Cited by 139 · see citing works
Self-citationZhong, P., Wang, W., Pan, B., Liu, X., Zhang, Z., Long, J. Z., Zhang, H., Cravatt, B. F., & Liu, Q.-S. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.24 · Cited by 137 · see citing works
Schiavon, A. P., Bonato, J. M., Milani, H., Guimarães, F. S., & Weffort de Oliveira, R. M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.017 · Cited by 135 · see citing works
Endocannabinoid System Components as Potential Biomarkers in Psychiatry
Navarrete, F., García‐Gutiérrez, M. S., Barba, R. J., Rubio, G., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00315 · Cited by 134 · see citing works
McLaughlin, R. J., Hill, M. N., & Gorzalka, B. B. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.02.006 · Cited by 130 · see citing works
Bambico, F. R., Nguyen, N.-T., & Gobbi, G. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.11.005 · Cited by 127 · see citing works
Self-citationMedical Marijuana Laws and Suicides by Gender and Age
Anderson, D. M., Rees, D. I., & Sabia, J. J. (2014) · American Journal of Public Health · doi:10.2105/ajph.2013.301612 · Cited by 121 · see citing works
Galdino, P. M., Nascimento, M. V. M., Florentino, I. F., Lino, R. C., Fajemiroye, J. O., Chaibub, B. A., de Paula, J. R., de Lima, T. C. M., & Costa, É. A. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.04.012 · Cited by 119 · see citing works
Gorzalka, B. B., & Hill, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.021 · Cited by 118 · see citing works
Passie, T., Emrich, H. M., Karst, M., Brandt, S. D., & Halpern, J. H. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1377 · Cited by 117 · see citing works
Modulation of the serotonin system by endocannabinoid signaling
Haj‐Dahmane, S., & Shen, R. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.016 · Cited by 117 · see citing works
The role of the gut-brain axis in depression: endocrine, neural, and immune pathways
Makris, A. P., Karianaki, M., Tsamis, K. I., & Paschou, S. Α. (2020) · HORMONES · doi:10.1007/s42000-020-00236-4 · Cited by 120 · see citing works
McLaughlin, R. J., Hill, M. N., Bambico, F. R., Stuhr, K. L., Gobbi, G., Hillard, C. J., & Gorzalka, B. B. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.01.004 · Cited by 113 · see citing works
Self-citationHill, M. N., & Patel, S. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-19 · Cited by 117 · see citing works
Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain
Guida, F., Boccella, S., Belardo, C., Iannotta, M., Piscitelli, F., Filippis, F. D., Paino, S., Ricciardi, F., Siniscalco, D., Marabese, I., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.04.006 · Cited by 111 · see citing works
Anhedonia in depression symptomatology: appetite dysregulation and defective brain reward processing
Coccurello, R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112041 · Cited by 106 · see citing works
Huestis, M. A., Mazzoni, I. E., & Rabin, O. (2011) · Sports Medicine · doi:10.2165/11591430-000000000-00000 · Cited by 110 · see citing works
De Gregorio, D., Posa, L., Ochoa-Sanchez, R., McLaughlin, R., Maione, S., Comai, S., & Gobbi, G. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.022 · Cited by 110 · see citing works
Self-citationSynthetic Cannabinoids: A Pharmacological and Toxicological Overview
Bravo, R. R., Silva, R. S., Malheiro, R. F., Carmo, H., Carvalho, F. D., da Silva, D. D., & Silva, J. P. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-031122-113758 · Cited by 106 · see citing works
The role of the CB1 receptor in the regulation of sleep
Murillo‐Rodríguez, E. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.04.008 · Cited by 107 · see citing works
Cannabinoid signaling in health and disease
Lu, Y., & Anderson, H. D. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0346 · Cited by 102 · see citing works
The Effect of Medical Marijuana Laws on Body Weight
Sabia, J. J., Swigert, J. M., & Young, T. C. (2015) · Health Economics · doi:10.1002/hec.3267 · Cited by 100 · see citing works
Akirav, I. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00034 · Cited by 100 · see citing works
Vinod, K. Y., Xie, S., Psychoyos, D., Hungund, B. L., Cooper, T. B., & Tejani‐Butt, S. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036743 · Cited by 97 · see citing works
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice
Umathe, S. N., Manna, S. S. S., & Jain, N. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.031 · Cited by 96 · see citing works
Jiang, B., Wang, Y., Wang, H., Song, L., Huang, C., Zhu, Q., Wu, F., & Zhang, W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13668 · Cited by 96 · see citing works
Jacob, W., Yassouridis, A., Marsicano, G., Monory, K., Lutz, B., & Wotjak, C. T. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00512.x · Cited by 95 · see citing works
Feingold, D., & Weinstein, A. M. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-57369-0_5 · Cited by 96 · see citing works
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
Sidhpura, N., & Parsons, L. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.034 · Cited by 92 · see citing works
Geddes, S. D., Assadzada, S., Lemelin, D., Sokolovski, A., Bergeron, R., Haj-Dahmane, S., & Béïque, J.-C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522754113 · Cited by 90 · see citing works
Malinen, H., & Hyytiä, P. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00786.x · Cited by 92 · see citing works
Endocannabinoids in the Treatment of Mood Disorders: Evidence from Animal Models
Bambico, F. R., Duranti, A., Tontini, A., Tarzia, G., & Gobbi, G. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168029 · Cited by 91 · see citing works
Self-citationModulatory effects of cannabinoids on brain neurotransmission
Cohen, K., Weizman, A., & Weinstein, A. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14407 · Cited by 92 · see citing works
Marzo, V. D. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/vdimarzo · Cited by 91 · see citing works
Bushlin, I., Gupta, A., Stockton, S. D., Miller, L. K., & Devi, L. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049789 · Cited by 90 · see citing works
Ren, S., Wang, Z., Zhang, Y., & Chen, N. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0385-7 · Cited by 88 · see citing works
Segev, A., Rubin, A. S., Abush, H., Richter‐Levin, G., & Akirav, I. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.292 · Cited by 88 · see citing works
Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential
Lowe, H., Steele, B., Bryant, J., Toyang, N., & Ngwa, W. (2021) · Plants · doi:10.3390/plants10020400 · Cited by 97 · see citing works
Lack of CB1 receptor activity impairs serotonergic negative feedback
Aso, E., Renoir, T., Mengod, G., Ledent, C., Hamon, M., Maldonado, R., Lanfumey, L., & Valverde, O. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06025.x · Cited by 92 · see citing works
Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04883-5 · Cited by 82 · see citing works
Self-citationThe Public Health Effects of Legalizing Marijuana
Anderson, D. M., & Rees, D. I. (2023) · Journal of Economic Literature · doi:10.1257/jel.20211635 · Cited by 85 · see citing works
Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
Roche, M., & Finn, D. P. (2010) · Pharmaceuticals · doi:10.3390/ph3082517 · Cited by 87 · see citing works
From endocannabinoid profiling to ‘endocannabinoid therapeutics’
Ligresti, A., Petrosino, S., & Marzo, V. D. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.04.615 · Cited by 85 · see citing works
Role of Endocannabinoid Signaling in Anxiety and Depression
Patel, S., & Hillard, C. J. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_14 · Cited by 85 · see citing works
Cannabinoids and emotionality: a neuroanatomical perspective
McLaughlin, R. J., & Gobbi, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.052 · Cited by 82 · see citing works
Self-citationReviewing the Role of the Endocannabinoid System in the Pathophysiology of Depression
Gallego‐Landin, I., García-Baos, A., Castro‐Zavala, A., & Valverde, O. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.762738 · Cited by 84 · see citing works
The cannabinoid CB 1 receptor and the endocannabinoid anandamide: possible antidepressant targets
Bambico, F. R., & Gobbi, G. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.11.1347 · Cited by 80 · see citing works
Self-citationEndocannabinoid Signaling in the Etiology and Treatment of Major Depressive Illness
Hillard, C. J., & Liu, Q.-S. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660735 · Cited by 79 · see citing works
The endocannabinoid system in mental disorders: Evidence from human brain studies
Ibarra‐Lecue, I., Pilar-Cuéllar, F., Muguruza, C., Florensa-Zanuy, E., Díaz, Á., Urigüen, L., Castro, E., Pazos, Á., & Callado, L. F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.009 · Cited by 80 · see citing works
Hill, M. N., Ho, W.-S. V., Hillard, C. J., & Gorzalka, B. B. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0131-7 · Cited by 75 · see citing works
Cannabis regulatory science: risk–benefit considerations for mental disorders
Borodovsky, J. T., & Budney, A. J. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1454406 · Cited by 73 · see citing works
Differential effects of TRPV1 receptor ligands against nicotine-induced depression-like behaviors
Hayase, T. (2011) · BMC Pharmacology · doi:10.1186/1471-2210-11-6 · Cited by 72 · see citing works
Neuronal populations mediating the effects of endocannabinoids on stress and emotionality
Häring, M., Guggenhuber, S., & Lutz, B. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.035 · Cited by 70 · see citing works
Smoke Gets in Your Eyes: Medical Marijuana Laws and Tobacco Cigarette Use
Choi, A., Dave, D., & Sabia, J. J. (2018) · American Journal of Health Economics · doi:10.1162/ajhe_a_00121 · Cited by 70 · see citing works
Cannabinoids: Current and Future Options to Treat Chronic and Chemotherapy-Induced Neuropathic Pain
Blanton, H. L., Brelsfoard, J., Deturk, N., Pruitt, K., Narasimhan, M., Morgan, D. J., & Guindon, J. (2019) · Drugs · doi:10.1007/s40265-019-01132-x · Cited by 70 · see citing works
Haj-Dahmane, S., & Shen, R.-Y. (2009) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.153858 · Cited by 69 · see citing works
Trezza, V., Campolongo, P., Manduca, A., Morena, M., Palmery, M., Vanderschuren, L. J. M. J., & Cuomo, V. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00002 · Cited by 68 · see citing works
Dellazizzo, L., Potvin, S., Athanassiou, M., & Dumais, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.567887 · Cited by 68 · see citing works
Rodríguez‐Gaztelumendi, A., Rojo, M. L., Pazos, Á., & Díaz, Á. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05898.x · Cited by 68 · see citing works
Chemical and Physical Elicitation for Enhanced Cannabinoid Production in Cannabis
Gorelick, J., & Bernstein, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-54564-6_21 · Cited by 68 · see citing works
McLaughlin, R. J., Hill, M. N., Dang, S. S., Wainwright, S. R., Galea, L. A. M., Hillard, C. J., & Gorzalka, B. B. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.053 · Cited by 65 · see citing works
Lee, T. T. Y., & Hill, M. N. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.017 · Cited by 67 · see citing works
Berger, A. L., Henricks, A. M., Lugo, J. M., Wright, H. R., Warrick, C. R., Sticht, M. A., Morena, M., Río, I. B., Laredo, S. A., Craft, R. M., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.04.018 · Cited by 66 · see citing works
Mendiguren, A., Aostri, E., & Pineda, J. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.029 · Cited by 66 · see citing works
dos Santos, A. H., Lisboa, S. F. D. S., Sonego, A. B., Coutinho, D., Gomes, F. V., & Guimarães, F. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109637 · Cited by 67 · see citing works
Berney, A., Nishikawa, M., Benkelfat, C., Debonnel, G., Gobbi, G., & Dikšić, M. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.08.021 · Cited by 63 · see citing works
Self-citationMato, S., Vidal, R., Castro, E., Díaz, Á., Pazos, Á., & Valdizán, E. M. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.060079 · Cited by 63 · see citing works
Synthetic Δ-9-Tetrahydrocannabinol (Dronabinol) Can Improve the Symptoms of Schizophrenia
SCHWARCZ, G., Karajgi, B. M., & McCarthy, R. H. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181a6bc3b · Cited by 62 · see citing works
Bambico, F. R., Hattan, P. R., Garant, J.-P., & Gobbi, G. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.02.006 · Cited by 61 · see citing works
Self-citationSmaga, I., Bystrowska, B., Gawliński, D., Pomierny, B., Stankowicz, P., & Filip, M. (2014) · Neurotoxicity Research · doi:10.1007/s12640-014-9465-0 · Cited by 61 · see citing works
Häring, M., Grieb, M., Monory, K., Lutz, B., & Moreira, F. A. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.09.002 · Cited by 59 · see citing works
Remodeling of microbiota gut-brain axis using psychobiotics in depression
Palepu, M. S. K., & Dandekar, M. P. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175171 · Cited by 59 · see citing works
- Authors
- Bambico, F. R., Katz, N., Debonnel, G., & Gobbi, G.
- Affiliations
- McGill University (CA)
- Institut universitaire en santé mentale de Montréal (CA)
- Corresponding author
- Gobbi, Gabriella
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-10-24
- Volume
- 27
- Issue
- 43
- Pages
- 11700-11711
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673235
- OpenAlex
- W2073174105
- Cited by
- 325
- References
- 81
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 15 · 2021: 27 · 2020: 20 · 2019: 19 · 2018: 20 · 2017: 14 · 2016: 13 · 2015: 13 · 2014: 15 · 2013: 14 · 2012: 27
- FWCI
- 13.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- McGill University Health Centre
- Canadian Psychiatric Research Foundation
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- cannabinoids, CB1 receptor agonists, WIN 55,212-2, antidepressant-like behavior, serotonin, dorsal raphe nucleus, ventromedial prefrontal cortex, forced swim test, rimonabant, p-chlorophenylalanine, depression
- MeSH terms
- Animals, Antidepressive Agents, Cannabinoids, Depression, Male, Morpholines, Naphthalenes, Neurons, Serotonin, Rats, Sprague-Dawley, Prefrontal Cortex, Receptor, Cannabinoid, CB1, Benzoxazines, Rats
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