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Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
Open accessAbstract
Exercise has been shown to be beneficial for Parkinson’s disease (PD). A major interest in our lab has been to investigate how exercise modulates basal ganglia function and modifies disease progression. Dopamine (DA) depletion leads to loss of dendritic spines within the caudate nucleus and putamen (striatum) in PD and its animal models and contributes to motor impairments. Striatal medium spiny neurons (MSNs) can be delineated into two populations, the dopamine D1 receptor (DA-D1R)-containing MSNs of the direct pathway and dopamine D2 receptor (DA-D2R)-containing MSNs of the indirect pathway. There is evidence to suggest that the DA-D2R-indirect pathway MSNs may be preferentially affected after DA-depletion with a predominate loss of dendritic spine density when compared to MSNs of the DA-D1R-direct pathway in rodents; however, others have reported that both pathways may be affected in primates. The purpose of this study was to investigate the effects of intensive exercise on dendritic spine density and arborization in MSNs of these two pathways in the MPTP mouse model of PD. We found that MPTP led to a decrease in dendritic spine density in both DA-D1R-and DA-D2R-containing MSNs and 30 days of intensive treadmill exercise led to increased dendritic spine density and arborization in MSNs of both pathways. In addition, exercise increased the expression of synaptic proteins PSD-95 and synaptophysin. Taken together these findings support the potential effect of exercise in modifying synaptic connectivity within the DA-depleted striatum and in modifying disease progression in individuals with PD.
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A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Black, J. E., Isaacs, K. R., Anderson, B. J., Alcantara, A. A., & Greenough, W. T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5568 · Cited by 1,161
Day, M., Wang, Z., Ding, J., An, X., Ingham, C. A., Shering, A. F., Wokosin, D., Ilijic, E., Sun, Z., Sampson, A. R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1632 · Cited by 745 · cited 7×
“Other receptors that are known to be modulate spine loss in the context of DA-depletion, such as the L-type calcium channel may play a role in exercise mediated effects on spine density (Day et al., 2006).”
BackgroundResultInfluentialTaverna, S., Ilijic, E., & Surmeier, D. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5493-07.2008 · Cited by 399
Running induces widespread structural alterations in the hippocampus and entorhinal cortex
Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327
Fisher, B. E., Petzinger, G. M., Nixon, K., Hogg, E., Bremmer, S., Meshul, C. K., & Jakowec, M. W. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20162 · Cited by 311
Atrophy of medium spiny I striatal dendrites in advanced Parkinson's disease
McNeill, T. H., Brown, S. A., Rafols, J. A., & Shoulson, I. (1988) · Brain Research · doi:10.1016/0006-8993(88)90124-2 · Cited by 246
Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age
Ingham, C. A., Hood, S. H., & Arbuthnott, G. W. (1989) · Brain Research · doi:10.1016/0006-8993(89)91686-7 · Cited by 219
Ingham, C. A., Hood, S. H., van Maldegem, B., Weenink, A., & Arbuthnott, G. W. (1993) · Experimental Brain Research · doi:10.1007/bf00227776 · Cited by 144
VanLeeuwen, J., Petzinger, G. M., Walsh, J. P., Akopian, G. K., Vuckovic, M., & Jakowec, M. W. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22216 · Cited by 94
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Fieblinger, T., Graves, S. M., Sebel, L. E., Alcacer, C., Plotkin, J. L., Gertler, T. S., Chan, C. S., Heiman, M., Greengard, P., Cenci, M. A., et al. (2014) · Nature Communications · doi:10.1038/ncomms6316 · Cited by 295
Palasz, E., Niewiadomski, W., Gasiorowska, A., Wysocka, A., Stepniewska, A., & Niewiadomska, G. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01143 · Cited by 95
The Oxygen Paradox, the French Paradox, and age-related diseases
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Self-citationda Costa Daniele, T. M., de Bruin, P. F. C., de Matos, R. S., de Bruin, G. S., Maia Chaves, C., & de Bruin, V. M. S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112488 · Cited by 59
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Metadata
- Authors
- Toy, W. A., Petzinger, G. M., Leyshon, B. J., Akopian, G. K., Walsh, J. P., Hoffman, M. V., Vučković, M. G., & Jakowec, M. W.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 63
- Pages
- 201-209
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2075398676
- Cited by
- 169
- References
- 10
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. https://app.cochat.ai/papers/10.1016/j.nbd.2013.11.017
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- Toy, W. A., Petzinger, G. M., Leyshon, B. J., Akopian, G. K., Walsh, J. P., Hoffman, M. V., Vučković, M. G., & Jakowec, M. W. (2014). Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Neurobiology of Disease. https://doi.org/10.1016/j.nbd.2013.11.017
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