The DOI matches its Crossref record; 109 of the 110 references it cites were found in a registry or an index.
MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions
Open accessAbstract
The post-transcriptional regulator molecules, microRNAs, have emerged as important biomarkers and modulators of numerous pathophysiological processes including oncogenesis and cardiovascular diseases. Recently, a significant number of dysregulations in microRNAs have been reported in patients suffering from painful disorders such as complex regional pain syndrome, cystitis-induced chronic pain and irritable bowel disorder, in both affected tissues and the circulation. Moreover, microRNAs are known to be involved in pain processing based on several recent findings in animal models of inflammatory and neuropathic pain. The basis of this review was to cover and summarize available articles in English encompassing "microRNA and pain". In animal pain models widespread microRNA modulation is present and manifests on multiple levels i.e.: the dorsal root ganglia, the spinal dorsal horn and the brain. Numerous functional in vivo studies have found that dysregulated microRNAs are involved in the post-transcriptional modulation of genes implicated in pain generation and maintenance. Lastly, a few animal studies have delivered promising results as to the possibility of applying microRNAs as therapeutics to alleviate established pain and several clinical studies have highlighted the potential in applying microRNAs as biomarkers in painful conditions such as complex regional pain syndrome and fibromyalgia. This review briefly introduces the basics of microRNAs, their biogenesis and function, and mainly focuses on the recent advances made in understanding the role of microRNAs in relation to pain processing and painful conditions. It also provides an overview of widely diverse methodological approaches and results with a potential for future implications of microRNAs in the diagnosis and treatment of pain.
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“Several studies highlighted the contribution of miRNAs in the modulation of the expression of ECM structural proteins and related signaling molecules, thus emphasizing the close relationship between ECM homeostasis and inflammatory pain related conditions [174,175,176].”
From Cellular and Molecular Mechanisms in the Pathogenesis of Classical, Vascular, and Hypermobile Ehlers‒Danlos Syndromes (2019) · cites this paper as [176]
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Metadata
- Authors
- Andersen, H. H., Duroux, M., & Gazerani, P.
- Affiliations
- Aalborg University (DK)
- Corresponding author
- Gazerani, Parisa
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 71
- Pages
- 159-168
- ISSN
- 0969-9961 (ISSN-L)
- OpenAlex
- W2140844751
- Cited by
- 175
- References
- 110
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 12 · 2023: 9 · 2022: 16 · 2021: 18 · 2020: 18 · 2019: 24 · 2018: 9 · 2017: 27 · 2016: 12 · 2015: 11 · 2014: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neurobiology of Disease (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- VBN Forskningsportal (Aalborg Universitet) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Novo Nordisk
- Forskerakademiet (831301)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- microRNA, inflammatory pain, neuropathic pain, pain biomarkers, complex regional pain syndrome, fibromyalgia, dorsal root ganglia, dorsal horn, pain processing, miRNA-based therapy, post-transcriptional regulation, animal models of pain
- MeSH terms
- Animals, Humans, Inflammation, Neuralgia, Biomarkers, MicroRNAs
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