Cited by 175Pain Mechanisms and TreatmentsMicroRNA in disease regulationIon Channels and Receptors

The DOI matches its Crossref record; 109 of the 110 references it cites were found in a registry or an index.

MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions

Open access

Andersen, Hjalte H., Duroux, Meg, Gazerani, Parisa·2014·Neurobiology of Disease

DOI 10.1016/j.nbd.2014.08.003

Open this paper in CoChat — free account Open PDF

Abstract

The post-transcriptional regulator molecules, microRNAs, have emerged as important biomarkers and modulators of numerous pathophysiological processes including oncogenesis and cardiovascular diseases. Recently, a significant number of dysregulations in microRNAs have been reported in patients suffering from painful disorders such as complex regional pain syndrome, cystitis-induced chronic pain and irritable bowel disorder, in both affected tissues and the circulation. Moreover, microRNAs are known to be involved in pain processing based on several recent findings in animal models of inflammatory and neuropathic pain. The basis of this review was to cover and summarize available articles in English encompassing "microRNA and pain". In animal pain models widespread microRNA modulation is present and manifests on multiple levels i.e.: the dorsal root ganglia, the spinal dorsal horn and the brain. Numerous functional in vivo studies have found that dysregulated microRNAs are involved in the post-transcriptional modulation of genes implicated in pain generation and maintenance. Lastly, a few animal studies have delivered promising results as to the possibility of applying microRNAs as therapeutics to alleviate established pain and several clinical studies have highlighted the potential in applying microRNAs as biomarkers in painful conditions such as complex regional pain syndrome and fibromyalgia. This review briefly introduces the basics of microRNAs, their biogenesis and function, and mainly focuses on the recent advances made in understanding the role of microRNAs in relation to pain processing and painful conditions. It also provides an overview of widely diverse methodological approaches and results with a potential for future implications of microRNAs in the diagnosis and treatment of pain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.nbd.2014.08.003

Cites

109 of 109 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

The expression profile of micro-RNA in endometrium and endometriosis and the influence of ovarian steroids on their expression
Pan, Q., Luo, X., Toloubeydokhti, T., & Chegini, N. (2007) · Molecular Human Reproduction · doi:10.1093/molehr/gam063 · Cited by 261
Retracted
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948
Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Breivik, H., Collett, B., Ventafridda, V., Cohen, R., & Gallacher, D. (2006) · European Journal of Pain · doi:10.1016/j.ejpain.2005.06.009 · Cited by 5,486
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsPreprint
Yi, R., Qin, Y., Macara, I. G., & Cullen, B. R. (2003) · Genes & Development · doi:10.1101/gad.1158803 · Cited by 3,158
Many roads to maturity: microRNA biogenesis pathways and their regulation
Winter, J. J., Jung, S., Keller, S., Gregory, R. I., & Diederichs, S. (2009) · Nature Cell Biology · doi:10.1038/ncb0309-228 · Cited by 2,770
Molecular mechanisms of nociception
Julius, D., & Basbaum, A. I. (2001) · Nature · doi:10.1038/35093019 · Cited by 2,685
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
Pasquinelli, A. E., Reinhart, B. J., Slack, F. J., Martindale, M. Q., Kuroda, M. I., Maller, B., Hayward, D. C., Ball, E. E., Degnan, B. M., Müller, P., et al. (2000) · Nature · doi:10.1038/35040556 · Cited by 2,671
The neuropathic pain triad: neurons, immune cells and glia
Scholz, J., & Woolf, C. J. (2007) · Nature Neuroscience · doi:10.1038/nn1992 · Cited by 1,738
Central sensitization and LTP: do pain and memory share similar mechanisms?
Ji, R., Kohno, T., Moore, K. A., & Woolf, C. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.017 · Cited by 1,462
MicroRNA-10a binds the 5’UTR of ribosomal protein mRNAs and enhances their translation
Ørom, U. A., Nielsen, F. C., & Lund, A. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.001 · Cited by 1,384
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
MicroRNA-Cancer Connection: The Beginning of a New Tale
Calin, G. A., & Croce, C. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0800 · Cited by 1,056
The Epidemiology of Chronic Pain of Predominantly Neuropathic Origin. Results From a General Population Survey
Torrance, N., Smith, B. H., Bennett, M., & Lee, A. J. (2006) · Journal of Pain · doi:10.1016/j.jpain.2005.11.008 · Cited by 1,001
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
Stańczyk, J., Pedrioli, D. M. L., Brentano, F., Sánchez‐Pernaute, O., Kolling, C., Gay, R. E., Detmar, M. J., Gay, S., & Kyburz, D. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23386 · Cited by 911
Nociceptor sensitization in pain pathogenesis
Gold, M. S., & Gebhart, G. F. (2010) · Nature Medicine · doi:10.1038/nm.2235 · Cited by 899
MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway
Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787
Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients
Pauley, K. M., Satoh, M., Chan, A. L., Bubb, M., Reeves, W. H., & Chan, E. K. L. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2493 · Cited by 770
A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy
Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704
Self-citation
Secreted microRNAs: a new form of intercellular communication
Chen, X., Liang, H., Zhang, J., Zen, K., & Zhang, C.-Y. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.12.001 · Cited by 690
Experimental and Clinical Applications of Quantitative Sensory Testing Applied to Skin, Muscles and Viscera
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548
Experimental strategies for microRNA target identification
Thomson, D. W., Bracken, C. P., & Goodall, G. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr330 · Cited by 544
MicroRNAs and cancer
McManus, M. T. (2003) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(03)00038-5 · Cited by 441
Expression of MicroRNA‐146a in osteoarthritis cartilage
Yamasaki, K., Nakasa, T., Miyaki, S., Ishikawa, M., Deie, M., Adachi, N., Yasunaga, Y., Asahara, H., & Ochi, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24404 · Cited by 407
Intercellular Transport of MicroRNAs
Boon, R. A., & Vickers, K. C. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300139 · Cited by 402
Clinical characteristics and economic costs of patients with painful neuropathic disorders
Berger, A., Dukes, E. M., & Oster, G. (2004) · Journal of Pain · doi:10.1016/j.jpain.2003.12.004 · Cited by 351
Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene
Reyes‐Gibby, C. C., Shete, S. S., Rakvåg, T. T. N., Bhat, S. V., Skorpen, F., Bruera, E. D., Kaasa, S., & Klepstad, P. (2006) · Pain · doi:10.1016/j.pain.2006.10.023 · Cited by 312
Robust MicroRNA Stability in Degraded RNA Preparations from Human Tissue and Cell Samples
Jung, M., Fendler, A., Steiner, I., Kempkensteffen, C., Stephan, C., Erbersdobler, A., & Jung, K. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2009.141580 · Cited by 300
Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1
Park, C.-K., Xu, Z.-Z., Berta, T., Han, Q., Chen, G., Liu, X.-J., & Ji, R.-R. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.011 · Cited by 289
MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome
Zhou, Q., Souba, W. W., Croce, C. M., & Verne, G. N. (2009) · Gut · doi:10.1136/gut.2009.181834 · Cited by 285
A Systematic Review of MicroRNA in Glioblastoma Multiforme: Micro-modulators in the Mesenchymal Mode of Migration and Invasion
Møller, H. G., Rasmussen, A. P., Andersen, H. H., Johnsen, K. B., Henriksen, M., & Duroux, M. C. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8349-7 · Cited by 273
Self-citation
Functional MicroRNA Involved in Endometriosis
Hawkins, S. M., Creighton, C. J., Han, D. Y., Zariff, A., Anderson, M. L., Gunaratne, P. H., & Matzuk, M. M. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0371 · Cited by 264
Altered microRNA expression following traumatic spinal cord injury
Liu, N.-K., Wang, X.-F., Lu, Q.-B., & Xu, X.-M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.06.015 · Cited by 243
Chronic Migraine: Epidemiology and Disease Burden
Manack, A. N., Buse, D. C., & Lipton, R. B. (2011) · Current Pain and Headache Reports · doi:10.1007/s11916-010-0157-z · Cited by 230
MicroRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury
Bhalala, O. G., Pan, L., Sahni, V., McGuire, T. L., Gruner, K., Tourtellotte, W. G., & Kessler, J. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3860-12.2012 · Cited by 220
MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
Li, X., GIBSON, G. J., Kim, J., Kroin, J. S., Xu, S., van Wijnen, A. J., & Im, H. (2011) · Gene · doi:10.1016/j.gene.2011.03.003 · Cited by 213
Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR‐103: role in pain
Favereaux, A., Thoumine, O. R., Bouali‐Benazzouz, R., Roques, V., Papon, M.-A., Salam, S. A., Drutel, G., Léger, C., Calas, A., Nagy, F., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.249 · Cited by 201
Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis
Wang, W.-T., Zhao, Y.-N., Han, B.-W., Hong, S.-J., & Chen, Y.-Q. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2415 · Cited by 193
MicroRNAs and neurodegeneration: role and impact
Abe, M., & Bonini, N. M. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.013 · Cited by 190
Pain hypersensitivity mechanisms at a glance
Gangadharan, V., & Kuner, R. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.011502 · Cited by 187
Functional transfer of microRNA by exosomes
Stoorvogel, W. (2012) · Blood · doi:10.1182/blood-2011-11-389478 · Cited by 174
MicroRNA modulation in complex regional pain syndrome
Orlova, I. A., Alexander, G. M., Qureshi, R., Saçan, A., Graziano, A., Barrett, J. E., Schwartzman, R. J., & Ajit, S. K. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-195 · Cited by 169
Small RNAs Control Sodium Channel Expression, Nociceptor Excitability, and Pain Thresholds
Zhao, J., Lee, M.-C., Momin, A., Cendán, C. M., Shepherd, S. T., Baker, M. D., Asante, C. O., Bee, L., Béthry, A., Perkins, J. R., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1980-10.2010 · Cited by 166
The role of microRNA in rheumatoid arthritis and other autoimmune diseases
Furer, V., Greenberg, J. D., Attur, M. G., Abramson, S. B., & Pillinger, M. H. (2010) · Clinical Immunology · doi:10.1016/j.clim.2010.02.005 · Cited by 165
Differential Expression of MicroRNAs in Mouse Pain Models
Kusuda, R., Cadetti, F., Ravanelli, M. I. B., Sousa, T. A. E., Zanon, S., Lucca, F. L. D., & Lucas, G. (2011) · Molecular Pain · doi:10.1186/1744-8069-7-17 · Cited by 164
New insights into visceral hypersensitivity—clinical implications in IBS
Zhou, Q., & Verne, G. N. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.83 · Cited by 161
Signature of circulating microRNAs in osteoarthritis
Beyer, C., Zampetaki, A., Lin, N., Kleyer, A., Perricone, C., Iagnocco, A., Distler, A., Langley, S. R., Gelse, K., Sesselmann, S., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204698 · Cited by 158
Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation
Aldrich, B. T., Frakes, E. P., Kasuya, J., Hammond, D. L., & Kitamoto, T. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.033 · Cited by 150
Dynamic Changes in the MicroRNA Expression Profile Reveal Multiple Regulatory Mechanisms in the Spinal Nerve Ligation Model of Neuropathic Pain
von Schack, D., Agostino, M. J., Murray, B. S., Li, Y., Reddy, P. S., Chen, J., Choe, S. E., Strassle, B. W., Li, C., Bates, B., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017670 · Cited by 148
Downregulation of Selective microRNAs in Trigeminal Ganglion Neurons Following Inflammatory Muscle Pain
Bai, G., Ambalavanar, R., Wei, D., & Dessem, D. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-15 · Cited by 147
Clinical, pathological and genetic characterization of hereditary sensory and autonomic neuropathy type 1 (HSAN I)
Houlden, H., King, R. H. M., Blake, J. C., Groves, M., Love, S., Woodward, C. E., Hammans, S. R., Nicoll, J. A. R., Lennox, G. G., O’Donovan, D. G., et al. (2005) · Brain · doi:10.1093/brain/awh712 · Cited by 137
MicroRNA-124 as a novel treatment for persistent hyperalgesia
Willemen, H. L., Huo, X.-J., Mao-Ying, Q.-L., Zijlstra, J., Heijnen, C. J., & Kavelaars, A. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-143 · Cited by 137
Changes in circulating microRNAs levels with exercise modality
Banzet, S., Chennaoui, M., Girard, O., Racinais, S., Drogou, C., Chalabi, H., & Koulmann, N. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00075.2013 · Cited by 129
Emerging technologies in extracellular vesicle-based molecular diagnostics
Jia, S., Zocco, D., Samuels, M. L., Chou, M. F., Chammas, R. J., Skog, J., Zarovni, N., Momen‐Heravi, F., & Kuo, W. P. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.893828 · Cited by 127
Functional and structural imaging of pain-induced neuroplasticity
Seifert, F. C., & Maihöfner, C. (2011) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32834a1079 · Cited by 123
Intrathecal miR-96 Inhibits Nav1.3 Expression and Alleviates Neuropathic Pain in Rat Following Chronic Construction Injury
Chen, H.-P., Zhou, W., Kang, L., Yan, H., Zhang, L., Xu, B., & Cai, W. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1192-z · Cited by 118
Noncoding RNAs
Lutz, B. M., Bekker, A., & Tao, Y. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000265 · Cited by 117
Noncoding RNAs: key molecules in understanding and treating pain
Bali, K. K., & Kuner, R. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.006 · Cited by 116
MicroRNAs May Mediate the Down-Regulation of Neurokinin-1 Receptor in Chronic Bladder Pain Syndrome
Sánchez-Freire, V., Burkhard, F. C., Kessler, T. M., Kuhn, A., Draeger, A., & Monastyrskaya, K. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090552 · Cited by 114
MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes
Akhtar, N., & Haqqi, T. M. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200519 · Cited by 111
Amedeo Avogadro's cry: What is 1 µg of exosomes?
Sverdlov, E. D. (2012) · BioEssays · doi:10.1002/bies.201200045 · Cited by 110
Epigenetic Modification of Spinal miR-219 Expression Regulates Chronic Inflammation Pain by Targeting CaMKIIγ
Pan, Z., Zhu, L., Li, Y., Hao, L.-Y., Cui, Y., Yang, J., Guo, Y., Zhang, S., Hua, L., Xue, Z., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5346-13.2014 · Cited by 105
Responses of microRNAs 124a and 223 following spinal cord injury in mice
Nakanishi, K., Nakasa, T., Tanaka, N., Ishikawa, M., Yamada, K., Yamasaki, K., Kamei, N., Izumi, B., Adachi, N., Miyaki, S., et al. (2009) · Spinal Cord · doi:10.1038/sc.2009.89 · Cited by 104
microRNAs in the onset and development of cardiovascular disease
Vickers, K. C., Rye, K., & Tabet, F. (2013) · Clinical Science · doi:10.1042/cs20130203 · Cited by 102
MicroRNA-mediated GABAAα-1 receptor subunit down-regulation in adult spinal cord following neonatal cystitis-induced chronic visceral pain in rats
Sengupta, J. N., Pochiraju, S., Kannampalli, P., Bruckert, M., Addya, S., Yadav, P., Miranda, A., Shaker, R., & Banerjee, B. (2012) · Pain · doi:10.1016/j.pain.2012.09.002 · Cited by 100
Change in MicroRNAs Associated with Neuronal Adaptive Responses in the Nucleus Accumbens under Neuropathic Pain
Imai, S., Saeki, M., Yanase, M., Horiuchi, H., Abe, M., Narita, M., Kuzumaki, N., Suzuki, T., & Narita, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0921-11.2011 · Cited by 99
Profile of Cerebrospinal microRNAs in Fibromyalgia
Bjersing, J. L., Lundborg, C., Bokarewa, M. I., & Mannerkorpi, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078762 · Cited by 98
MiR-194 Regulates Chondrogenic Differentiation of Human Adipose-Derived Stem Cells by Targeting Sox5
Xu, J., Kang, Y. Q., Liao, W., & Yu, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031861 · Cited by 94
Increased expression of substance P receptor‐encoding mRNA in bladder biopsies from patients with interstitial cystitis
Marchand, Sant, & Kream (1998) · British Journal of Urology · doi:10.1046/j.1464-410x.1998.00507.x · Cited by 93
MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes
Park, S. J., Cheon, E. J., & Kim, H. A. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.04.012 · Cited by 89
Neurobiology of pain
Pace, M. C., Mazzariello, L., Passavanti, M. B., Sansone, P., Barbarisi, M., & Aurilio, C. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20693 · Cited by 88
Altered Spinal MicroRNA-146a and the MicroRNA-183 Cluster Contribute to Osteoarthritic Pain in Knee Joints
Li, X., Kroin, J. S., Kc, R., GIBSON, G. J., Chen, D., Corbett, G. T., Pahan, K., Fayyaz, S., Kim, J., van Wijnen, A. J., et al. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2002 · Cited by 86
Molecular targeting of NOX4 for neuropathic pain after traumatic injury of the spinal cord
Im, Y. B., Jee, M. K., Choi, J.-Y., Cho, H. T., Kwon, O. H., & Kang, S. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.168 · Cited by 83
MicroRNA in Osteoarthritis
Yu, C., Chen, W.-P., & Xh, W. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900101 · Cited by 81
Modulation of central nervous system–specific microRNA-124a alters the inflammatory response in the formalin test in mice
Kynast, K. L., Russe, O. Q., Möser, C. V., Geißlinger, G., & Niederberger, E. (2012) · Pain · doi:10.1016/j.pain.2012.11.010 · Cited by 80
Characterization of microRNA expression profiles in patients with intervertebral disc degeneration
Zhao, B., Yu, Q., Li, H.-P., Guo, X., & He, X.-J. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1543 · Cited by 80
Human pain and genetics: some basics
James, S. K. (2013) · British Journal of Pain · doi:10.1177/2049463713506408 · Cited by 76
MicroRNA changes in the mouse prefrontal cortex after inflammatory pain
Pohl, K., Yeol, J., & Ongl, W. (2011) · European Journal of Pain · doi:10.1016/j.ejpain.2011.02.002 · Cited by 74
Reduction of Voltage Gated Sodium Channel Protein in DRG by Vector Mediated miRNA Reduces Pain in Rats with Painful Diabetic Neuropathy
Chattopadhyay, M., Zhou, Z., Hao, S., Mata, M. M., & Fink, D. J. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-17 · Cited by 70
microRNA changes in the dorsal horn of the spinal cord of rats with chronic constriction injury: A TaqMan® Low Density Array study
Genda, Y., Arai, M., Ishikawa, M., TANAKA, S., OKABE, T., & Sakamoto, A. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1163 · Cited by 68
Regulation of μ‐opioid type 1 receptors by micro RNA 134 in dorsal root ganglion neurons following peripheral inflammation
Ni, J., Gao, Y., Gong, S., Guo, S., Hisamitsu, T., & Jiang, X. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00197.x · Cited by 68
MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern
Wu, D., Raafat, M., Pak, E. S., Hammond, S., & Murashov, A. K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.017 · Cited by 63
Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain
Brandenburger, T., Castoldi, M., Brendel, M., Grievink, H., Schlösser, L., Werdehausen, R., Bauer, I., & Hermanns, H. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.11.023 · Cited by 59
Post‐transcriptional regulation of mouse μ opioid receptor (MOR1) via its 3′ untranslated region: a role for microRNA23b
Wu, Q., Law, P., Wei, L., & Loh, H. H. (2008) · The FASEB Journal · doi:10.1096/fj.08-108175 · Cited by 57
Cardiovascular extracellular microRNAs: emerging diagnostic markers and mechanisms of cell-to-cell RNA communication
Kinet, V., Halkein, J., Dirkx, E., & Windt, L. J. D. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00214 · Cited by 55
MicroRNAs as new players in the pain game
Niederberger, E., Kynast, K. L., Lötsch, J., & Geißlinger, G. (2011) · Pain · doi:10.1016/j.pain.2011.01.042 · Cited by 53
MicroRNA in carcinogenesis & cancer diagnostics: a new paradigm.
Ahmad, J., Hasnain, S. E., Siddiqui, M. A., Ahamed, M., Musarrat, J., & Al-Khedhairy, A. A. (2013) · Europe PMC (PubMed Central) · Cited by 53
Biogenesis and the regulation of the maturation of miRNAs
Tran, N., & Hutvágner, G. (2013) · Essays in Biochemistry · doi:10.1042/bse0540017 · Cited by 52
Sources of Individual Variability: Mirnas That Predispose to Neuropathic Pain Identified Using Genome-Wide Sequencing
Bali, K. K., Hackenberg, M., Lubin, A., Kuner, R., & Devor, M. G. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-22 · Cited by 51
The miRNA and mRNA Changes in Rat Hippocampi after Chronic Constriction Injury
Arai, M., Genda, Y., Ishikawa, M., Shunsuke, T., Okabe, T., & Sakamoto, A. (2013) · Pain Medicine · doi:10.1111/pme.12066 · Cited by 49
Deciphering microRNA code in pain and inflammation: lessons from bladder pain syndrome
Gheinani, A. H., Burkhard, F. C., & Monastyrskaya, K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1275-7 · Cited by 48
miR-203 Regulates Nociceptive Sensitization after Incision by Controlling Phospholipase A2 Activating Protein Expression
Sun, Y., Li, X., Sahbaie, P., Shi, X., Li, W., Liang, D., & Clark, J. D. (2012) · Anesthesiology · doi:10.1097/aln.0b013e31826571aa · Cited by 47
A review of topical high‐concentration L ‐menthol as a translational model of cold allodynia and hyperalgesia
Andersen, H. H., Olsen, R. V., Møller, H. G., Eskelund, P. W., Gazerani, P., & Arendt‐Nielsen, L. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00380.x · Cited by 46
Self-citation
MicroRNA-143 expression in dorsal root ganglion neurons
Tam, S. T., Bastian, I., Zhou, X., Hoek, M. V., Michael, M., Gibbins, I. L., & Haberberger, R. V. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1263-x · Cited by 45
Differential expression of miRNAs in the nervous system of a rat model of bilateral sciatic nerve chronic constriction injury
Li, H., Shen, L., Ma, C., & Huang, Y. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1381 · Cited by 45
Novel findings in pain processing pathways: implications for miRNAs as future therapeutic targets
Kynast, K. L., Russe, O. Q., Geißlinger, G., & Niederberger, E. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/ern.13.34 · Cited by 40
High prevalence of confirmed, but also of potential and believed, neuropathic pain in pain clinics
Pérez, C., Ribera, M. V., Gálvez, R., Micó, J. A., Barutell, C., Failde, I., Sánchez‐Magro, I., & Stern, A. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00204.x · Cited by 28
Health Economic and Quality of Life Considerations in the Management of Pain
Phillips, C. J. (2003) · Drugs · doi:10.2165/00003495-200363992-00007 · Cited by 19
[Pain management: health economics and quality of life considerations].
Phillips, C. J. (2003) · PubMed · Cited by 18
Circulating miRNA profiling to identify biomarkers of dysmetabolism.
Tomaselli, S., Panera, N., Gallo, A., & Alisi, A. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.91 · Cited by 16
Cluster Headache and Parietal Glioblastoma Multiforme
Edvardsson, B., & Persson, S. (2012) · The Neurologist · doi:10.1097/nrl.0b013e31825cf181 · Cited by 12
OP0003 Signature of Circulating Micrornas in Osteoarthritis
Beyer, C., Zampetaki, A., Lin, N.-Y., Kleyer, A., Perricone, C., Iagnocco, A., Distler, A., Langley, S. L., Gelse, K., Sesselmann, S., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2014-eular.1839 · Cited by 9
Challenges of Chronic Pain Management: Public Health Consequences and Considered Responses
Finch, J. W. (2013) · North Carolina Medical Journal · doi:10.18043/ncm.74.3.243 · Cited by 8
Tam tam I
Henry, P. (1950) · Cited by 5

Sorted by citations

Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083891 · Cited by 768
Inflammation in the pathophysiology of neuropathic pain
Sommer, C., Leinders, M., & Üçeyler, N. (2017) · Pain · doi:10.1097/j.pain.0000000000001122 · Cited by 515
Fibromyalgia: Genetics and epigenetics insights may provide the basis for the development of diagnostic biomarkers
D’Agnelli, S., Arendt‐Nielsen, L., Gerra, M. C., Zatorri, K., Boggiani, L., Baciarello, M., & Bignami, E. G. (2018) · Molecular Pain · doi:10.1177/1744806918819944 · Cited by 209
MicroRNA biomarkers of Parkinson’s disease in serum exosome-like microvesicles
Cao, X., Lu, J., Zhao, Z., Li, M.-C., Lu, T., An, X., & Xue, L. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.045 · Cited by 214
Identification of the Spinal Expression Profile of Non-coding RNAs Involved in Neuropathic Pain Following Spared Nerve Injury by Sequence Analysis
Zhou, J., Xiong, Q., Chen, H., Yang, C., & Fan, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00091 · Cited by 142

See all 175

Authors: Andersen, H. H., Duroux, M., & Gazerani, P.
Affiliations: Aalborg University (DK)
Corresponding author: Gazerani, Parisa
ORCID: Andersen, Hjalte H.
Duroux, Meg
Gazerani, Parisa
Venue: Neurobiology of Disease
Publisher: Elsevier BV
Published: 2014-11
Volume: 71
Pages: 159-168
ISSN: 0969-9961 (ISSN-L)
DOI: 10.1016/j.nbd.2014.08.003
OpenAlex: W2140844751
Cited by: 175
References: 110
Citations by year: 2026: 7 · 2025: 10 · 2024: 12 · 2023: 9 · 2022: 16 · 2021: 18 · 2020: 18 · 2019: 24 · 2018: 9 · 2017: 27 · 2016: 12 · 2015: 11 · 2014: 2
FWCI: 2.04
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/3.0/ (vor)
Locations: Neurobiology of Disease (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
VBN Forskningsportal (Aalborg Universitet) (publishedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Novo Nordisk
Forskerakademiet (831301)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: microRNA, inflammatory pain, neuropathic pain, pain biomarkers, complex regional pain syndrome, fibromyalgia, dorsal root ganglia, dorsal horn, pain processing, miRNA-based therapy, post-transcriptional regulation, animal models of pain
MeSH terms: Animals, Humans, Inflammation, Neuralgia, Biomarkers, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks