Dynamics of biomarkers across the stages of traumatic spinal cord injury-implications for neural plasticity and repair

Begenisic, Tatjana; Pavese, Chiara; Aiachini, Beatrice; Nardone, Antonio; Rossi, Daniela

doi:10.3233/rnn-211169

Cited by 7Spinal Cord Injury ResearchNerve injury and regenerationTraumatic Brain Injury and Neurovascular Disturbances

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Dynamics of biomarkers across the stages of traumatic spinal cord injury-implications for neural plasticity and repair

Begenisic, Tatjana, Pavese, Chiara, Aiachini, Beatrice, Nardone, Antonio, Rossi, Daniela·2021·Restorative Neurology and Neuroscience

DOI 10.3233/rnn-211169

Open this paper in CoChat — free account

Abstract

Background Traumatic spinal cord injury (SCI) is a complex medical condition causing significant physical disability and psychological distress. While the adult spinal cord is characterized by poor regenerative potential, some recovery of neurological function is still possible through activation of neural plasticity mechanisms. We still have limited knowledge about the activation of these mechanisms in the different stages after human SCI. Objective In this review, we discuss the potential role of biomarkers of SCI as indicators of the plasticity mechanisms at work during the different phases of SCI. Methods An extensive review of literature related to SCI pathophysiology, neural plasticity and humoral biomarkers was conducted by consulting the PubMed database. Research and review articles from SCI animal models and SCI clinical trials published in English until January 2021 were reviewed. The selection of candidates for humoral biomarkers of plasticity after SCI was based on the following criteria: 1) strong evidence supporting involvement in neural plasticity (mandatory); 2) evidence supporting altered expression after SCI (optional). Results Based on selected findings, we identified two main groups of potential humoral biomarkers of neural plasticity after SCI: 1) neurotrophic factors including: Brain derived neurotrophic factor (BDNF), Nerve growth factor (NGF), Neurotrofin-3 (NT-3), and Insulin-like growth factor 1 (IGF-1); 2) other factors including: Tumor necrosis fac…

Integrity signals

Registry

Crossref · 10.3233/rnn-211169

Cites

8 of 8 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Gao, J., Wang, W.-Y., Mao, Y.-W., Gräff, J., Guan, J.-S., Pan, L., Mak, G., Kim, D., Su, S. C., & Tsai, L.-H. (2010) · Nature · doi:10.1038/nature09271 · Cited by 975
The dual role of the extracellular matrix in synaptic plasticity and homeostasis
Dityatev, A., Schachner, M., & Sonderegger, P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2898 · Cited by 559
Interleukin-1β (IL-1β) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro
Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12252-4 · Cited by 433
Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately
Wang, X.-B., Bozdagi, O., Nikitczuk, J. S., Zhai, Z. W., Zhou, Q., & Huntley, G. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807248105 · Cited by 316
Resolving TRPV1- and TNF-α-Mediated Spinal Cord Synaptic Plasticity and Inflammatory Pain with Neuroprotectin D1
Park, C.-K., Lü, N., Xu, Z.-Z., Liu, T., Serhan, C. N., & Ji, R.-R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2443-11.2011 · Cited by 241
Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators
Suh, H.-S., Zhao, M.-L., Derico, L., Choi, N., & Lee, S. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-37 · Cited by 226
MicroRNAs as modulators and biomarkers of inflammatory and neuropathic pain conditions
Andersen, H. H., Duroux, M., & Gazerani, P. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.08.003 · Cited by 175

Flagged first, then by citations

Show all 8 references

Research works printed but not linked: 231

10.1097/BRS.0000000000000654 · DOI
10.1093/neuros/nyw080 · DOI
10.3389/fneur.2019.00027 · DOI · Paper page
10.1089/neu.2018.5935 · DOI
10.1038/nn1166 · DOI
10.1016/0006-8993(91)90199-6 · DOI
10.1038/nn1195 · DOI
10.1038/cdd.2009.193 · DOI · Paper page
10.1002/ana.22421 · DOI
10.1523/JNEUROSCI.3583-09.2009 · DOI
10.1126/science.1067859 · DOI · Paper page
10.1016/S0896-6273(02)01005-X · DOI
10.1073/pnas.90.16.7859 · DOI
10.1152/ajpcell.1992.263.1.C1 · DOI
10.1002/jnr.10256 · DOI
10.1038/jcbfm.1993.112 · DOI
10.1038/sc.2015.28 · DOI
10.1038/nm.2107 · DOI
10.1111/j.1460-9568.2011.07950.x · DOI
10.1152/jn.00391.2007 · DOI
10.1016/j.nlm.2011.04.004 · DOI
10.1016/j.expneurol.2004.03.017 · DOI
10.1038/nm0796-788 · DOI
10.1046/j.1460-9568.1998.00454.x · DOI
10.1073/pnas.0510645103 · DOI
10.1111/j.1460-9568.2005.03982.x · DOI
10.1186/1471-2377-7-17 · DOI
10.1016/j.neuroscience.2003.11.040 · DOI
10.1182/blood.V84.7.2068.2068 · DOI
10.1385/MN:27:2:153 · DOI
10.1161/STROKEAHA.106.481556 · DOI
10.1126/science.1071924 · DOI
10.1089/neu.2006.23.1254 · DOI
10.1016/j.neulet.2008.04.043 · DOI
10.1002/nbm.1343 · DOI · Paper page
10.1016/S0165-0173(98)00004-6 · DOI
10.1007/s004010050754 · DOI
10.1016/S0166-2236(02)02143-4 · DOI · Paper page
10.1016/S0003-9993(98)90213-1 · DOI
10.1089/neu.2007.0468 · DOI
10.1097/00005072-199612000-00002 · DOI
10.1016/j.neulet.2008.01.070 · DOI
10.1111/j.1749-6632.2010.05499.x · DOI
10.1016/j.apmr.2007.08.004 · DOI
10.1097/00001756-200011090-00029 · DOI
10.1016/j.wneu.2018.10.206 · DOI
10.1002/(SICI)1097-4695(199912)41:4<540::AID-NEU9>3.0.CO;2-P · DOI
10.1093/brain/awt262 · DOI
10.1006/mcne.2001.0986 · DOI
10.1016/j.neuroscience.2016.03.056 · DOI
10.1016/S0079-6123(08)61764-1 · DOI
10.1073/pnas.87.14.5454 · DOI · Paper page
10.1111/j.1460-9568.1991.tb00031.x · DOI
10.1002/jnr.21273 · DOI · Paper page
10.1523/JNEUROSCI.20-11-04059.2000 · DOI
10.1038/369658a0 · DOI
10.1089/neu.2015.4294 · DOI
10.1523/JNEUROSCI.3708-08.2008 · DOI
10.3389/fphys.2012.00399 · DOI
10.1046/j.1460-9568.1999.00623.x · DOI
10.2174/187152711794653751 · DOI
10.1016/S1474-4422(13)70146-7 · DOI
10.1101/gr.082701.108 · DOI · Paper page
10.1523/JNEUROSCI.11-06-01577.1991 · DOI
10.1155/2012/789083 · DOI
10.1523/JNEUROSCI.21-13-04891.2001 · DOI
10.1152/jn.00179.2005 · DOI
10.1155/2016/9857201 · DOI
Gluckman, P.D., 1992, Acta Paediatrica - Supplement, 383, 134
Goussev, S., 2003, Journal of Neurosurgery, 99, 188
10.3389/fncir.2014.00100 · DOI
10.1523/JNEUROSCI.17-14-05560.1997 · DOI
10.1016/j.pneurobio.2003.08.002 · DOI
10.1038/jcbfm.1993.79 · DOI
10.1038/nature09267 · DOI · Paper page
10.1016/j.neuroscience.2007.05.051 · DOI
10.1046/j.0953-816x.2001.01484.x · DOI · Paper page
10.1016/S0306-4522(01)00353-0 · DOI
10.1038/sc.2014.86 · DOI
10.1089/neu.2000.17.203 · DOI
10.1089/08977150260139129 · DOI
10.1073/pnas.84.23.8735 · DOI
10.1016/j.nicl.2014.09.002 · DOI
10.1006/mcne.1999.0771 · DOI
10.1016/j.expneurol.2008.09.014 · DOI
10.1523/JNEUROSCI.1993-06.2006 · DOI
10.1371/journal.pone.0039751 · DOI
10.1016/j.neuroscience.2011.10.028 · DOI
10.1089/neu.2017.5576 · DOI
10.1074/jbc.M403172200 · DOI
Hydbring, P., 2013, FResearch, 2, 136
10.1016/0014-5793(94)00960-0 · DOI
10.1007/s11033-014-3176-8 · DOI
10.1016/S0014-4886(03)00087-6 · DOI
10.1093/brain/awv125 · DOI
10.1177/1545968307301872 · DOI
10.1186/s12987-020-00230-3 · DOI · Paper page
10.1016/j.neuron.2006.03.011 · DOI
10.4068/cmj.2015.51.2.51 · DOI
10.1016/0006-291X(91)92113-X · DOI
10.1016/j.neures.2009.09.003 · DOI
10.1016/S0165-5728(98)00273-2 · DOI
10.1186/1756-6606-2-27 · DOI · Paper page
10.1038/nrn2037 · DOI
10.1523/JNEUROSCI.19-17-07405.1999 · DOI
10.1016/0092-8674(88)90486-2 · DOI
Kuo, H.C., 2010, Reviews in Urology, 12, e69
10.1016/j.bbrc.2010.02.088 · DOI
10.1038/s41393-019-0319-8 · DOI
10.1515/CCLM.2011.068 · DOI
10.1089/neu.2016.4435 · DOI
10.3389/fnagi.2017.00365 · DOI
10.1016/0092-8674(91)90442-2 · DOI
10.1126/science.1065057 · DOI · Paper page
10.1097/00004647-199603000-00007 · DOI
10.1126/science.3306916 · DOI
10.1016/0006-8993(90)90738-W · DOI
10.3233/RNN-1995-7405 · DOI
10.3892/ijmm.2016.2455 · DOI
10.4103/bc.bc_11_18 · DOI
10.1038/nature03315 · DOI · Paper page
10.1016/j.expneurol.2011.11.018 · DOI
10.1097/BRS.0000000000001323 · DOI
10.1016/j.neuron.2017.07.037 · DOI
10.1016/j.neuropharm.2006.09.011 · DOI
10.1016/0955-2235(94)00008-9 · DOI
10.1016/S0896-6273(03)00538-5 · DOI
10.1038/nrn1726 · DOI · Paper page
10.3727/096368910X492634 · DOI
10.1089/neu.2009.1002 · DOI
10.1016/0896-6273(90)90089-X · DOI
10.1126/science.2321006 · DOI · Paper page
10.1016/j.neuron.2004.09.012 · DOI · Paper page
10.1126/science.285.5435.1870 · DOI · Paper page
10.1016/j.mam.2012.06.005 · DOI
10.1155/2015/736104 · DOI
10.1523/JNEUROSCI.1801-06.2006 · DOI
10.1002/jnr.490420310 · DOI
10.1016/j.arr.2004.08.001 · DOI
10.1111/j.1471-4159.2005.03565.x · DOI
10.1016/S0304-3940(01)02576-9 · DOI
10.1038/sc.2016.104 · DOI
10.1371/journal.pone.0159764 · DOI
10.1016/S0169-328X(02)00132-8 · DOI · Paper page
10.1038/nm.2160 · DOI
10.1523/JNEUROSCI.4359-05.2006 · DOI · Paper page
10.1067/mtc.2001.114101 · DOI
10.3389/fnins.2016.00052 · DOI
10.7150/ijbs.9058 · DOI
10.1523/JNEUROSCI.22-17-07526.2002 · DOI
10.1002/glia.21191 · DOI
10.1016/S0304-3940(02)00120-9 · DOI
10.1007/s13311-011-0034-4 · DOI
10.1038/nrm2125 · DOI · Paper page
10.1126/science.1161566 · DOI · Paper page
10.1016/j.cellsig.2010.01.010 · DOI
10.1093/jnen/63.6.641 · DOI
10.1038/312724a0 · DOI
10.1006/nbdi.2001.0435 · DOI
10.1002/(SICI)1096-9861(19970120)377:3<443::AID-CNE10>3.0.CO;2-S · DOI
10.1002/cne.21358 · DOI
10.1007/s11064-017-2464-9 · DOI
Rao, J.S., 2018, Proceedings of the National Academy of Sciences of the United States of America, 115, 5604
10.3389/fnmol.2013.00039 · DOI · Paper page
10.1016/j.critrevonc.2010.11.004 · DOI
10.1016/0165-3806(93)90165-7 · DOI
10.1152/jn.00164.2007 · DOI
10.1007/s12035-017-0858-y · DOI
10.18632/oncotarget.9174 · DOI
10.1161/01.STR.0000223001.06264.af · DOI
10.1016/S0006-8993(00)03294-7 · DOI · Paper page
10.1016/0006-8993(95)01089-0 · DOI
10.1161/01.STR.32.5.1162 · DOI · Paper page
10.1002/(SICI)1097-4695(19980915)36:4<455::AID-NEU1>3.0.CO;2-V · DOI
10.1172/JCI97837 · DOI
10.1152/physrev.00036.2012 · DOI · Paper page
10.1093/cercor/bhx106 · DOI
10.1016/j.immuni.2004.08.017 · DOI
10.1016/0006-8993(91)91309-O · DOI
10.1042/bj3140951 · DOI
10.1016/S0022-5347(05)64369-8 · DOI
10.1097/01.ju.0000088340.26588.74 · DOI
10.1016/j.brainres.2011.03.019 · DOI
10.1016/S0955-0674(98)80035-5 · DOI
10.1073/pnas.81.24.7951 · DOI
10.1074/jbc.270.15.8650 · DOI
10.1074/jbc.270.12.6440 · DOI
10.1074/jbc.M112129200 · DOI
10.1146/annurev.cellbio.17.1.463 · DOI · Paper page
10.1006/exnr.1998.6835 · DOI
10.3389/fncir.2014.00117 · DOI
Tagami, M., 1997, Laboratory Investigation, 76, 613
10.3233/RNN-2006-00332 · DOI
10.1046/j.1471-4159.1999.0730548.x · DOI
10.1016/0165-5728(93)90008-M · DOI
10.1523/JNEUROSCI.5123-04.2005 · DOI · Paper page
10.1089/neu.2019.6375 · DOI
10.1073/pnas.96.14.7714 · DOI
10.1038/s41598-017-01299-x · DOI
10.1212/WNL.41.8.1276 · DOI

200 of 231 shown

Sorted by citations

Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery
Tanaka, M. (2026) · Biomedicines · doi:10.3390/biomedicines14061265

See all 7

Authors: Begenisic, T., Pavese, C., Aiachini, B., Nardone, A., & Rossi, D.
Affiliations: University of Pavia (IT)
Istituti Clinici Scientifici Maugeri (IT)
Corresponding author: Nardone, Antonio
ORCID: Pavese, Chiara
Nardone, Antonio
Rossi, Daniela
Venue: Restorative Neurology and Neuroscience
Publisher: SAGE Publications
Published: 2021-02-05
Volume: 39
Issue: 5
Pages: 339-366
ISSN: 0922-6028 (ISSN-L)
1878-3627
DOI: 10.3233/rnn-211169
OpenAlex: W3207698455
Cited by: 7
References: 8
Citations by year: 2025: 3 · 2024: 1 · 2023: 1 · 2022: 2
FWCI: 0.18
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Restorative Neurology and Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: traumatic spinal cord injury, biomarkers, neuroplasticity, neurotrophic factors, brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3, insulin-like growth factor I, TNF-α, matrix metalloproteinases, microRNA, maladaptive plasticity, functional recovery
MeSH terms: Animals, Neuronal Plasticity, Spinal Cord, Spinal Cord Injuries, Biomarkers, Recovery of Function, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dynamics of biomarkers across the stages of traumatic spinal cord injury-implications for neural plasticity and repair

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks