Caffeine acts through neuronal adenosine A 2A receptors to prevent mood and memory dysfunction triggered by chronic stress

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Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer’s disease amyloidosis

Hollnagel, J., Elzoheiry, S., Gorgas, K., Kins, S., Beretta, C. A., Kirsch, J., Kuhse, J., Kann, O., & Kiss, É. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209228 · Cited by 80 · see citing works

Role of Adenosine in Epilepsy and Seizures

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The Role of Adenosine Signaling in Headache: A Review

Fried, N. T., Elliott, M. B., & Oshinsky, M. L. (2017) · Brain Sciences · doi:10.3390/brainsci7030030 · Cited by 76 · see citing works

Purine nucleosides in neuroregeneration and neuroprotection

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Effect of Ketamine on LTP and NMDAR EPSC in Hippocampus of the Chronic Social Defeat Stress Mice Model of Depression

Yang, Y., Ju, W., Zhang, H., & Sun, L. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00229 · Cited by 75 · see citing works

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Canas, P. M., Porciúncula, L. O., Simões, A. P., Augusto, E., Silva, H. B. L., Machado, N. J., Gonçalves, N., Alfaro, T. M., Gonçalves, F. Q., Araújo, I. M., et al. (2018) · eNeuro · doi:10.1523/eneuro.0385-18.2018 · Cited by 74 · see citing works

Habitual coffee drinkers display a distinct pattern of brain functional connectivity

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Astrocytes and major depression: The purinergic avenue

Zhao, Y. F., Verkhratsky, A., Tang, Y. C., & Illés, P. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109252 · Cited by 73 · see citing works

Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula

Wang, M., Li, P., Li, Z., da Silva, B. S., Zheng, W., Xiang, Z., He, Y., Xu, T., Cordeiro, C., Deng, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37601-x · Cited by 73 · see citing works

Adenosine A2A receptor as potential therapeutic target in neuropsychiatric disorders

Domenici, M. R., Ferrante, A., Martire, A., Chiodi, V., Pepponi, R., Tebano, M. T., & Popoli, P. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104338 · Cited by 70 · see citing works

Adenosine Receptors in Neuropsychiatric Disorders: Fine Regulators of Neurotransmission and Potential Therapeutic Targets

Pasquini, S., Contri, C., Merighi, S., Gessi, S., Borea, P. A., Varani, K., & Vincenzi, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031219 · Cited by 68 · see citing works

The Pharmacological Potential of Adenosine A2A Receptor Antagonists for Treating Parkinson’s Disease

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Purinergic signalling and brain development

Rodrigues, R. J., Marques, J. M., & Cunha, R. A. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.12.001 · Cited by 65 · see citing works

Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid β (Aβ1‐40) administration in mice

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Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

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Purinergic Signaling and Related Biomarkers in Depression

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Caffeine enhances the antidepressant-like activity of common antidepressant drugs in the forced swim test in mice

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Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists

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Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

Machado, N. J., Simões, A. P., Silva, H. B. L., Ardais, A. P., Kaster, M. P., Garção, P., Rodrigues, D. I., Pochmann, D., Santos, A. I., Araújo, I. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9774-9 · Cited by 60 · see citing works

Associations Between Caffeine Consumption, Cognitive Decline, and Dementia: A Systematic Review

Chen, J. Q. A., Scheltens, P., Groot, C., & Ossenkoppele, R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201069 · Cited by 61 · see citing works

Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems

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Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis

Romualdo, G. R., Bartolomeu, A. R., Vinken, M., Cogliati, B., Moreno, F. S., García, M. Á., & Barbisan, L. F. (2019) · Food Research International · doi:10.1016/j.foodres.2019.05.029 · Cited by 62 · see citing works

Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy

Hu, Q., Ren, X., Liu, Y., Li, Z., Zhang, L., Chen, X., He, C., & Chen, J. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.040 · Cited by 55 · see citing works

Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

Naumenko, V. S., & Ponimaskin, E. G. (2018) · Neural Plasticity · doi:10.1155/2018/5701348 · Cited by 55 · see citing works

Antidepressant-Like Activity of Typical Antidepressant Drugs in the Forced Swim Test and Tail Suspension Test in Mice Is Augmented by DMPX, an Adenosine A2A Receptor Antagonist

Poleszak, E., Szopa, A., Bogatko, K., Wyska, E., Wośko, S., Świąder, K., Doboszewska, U., Właź, A., Wróbel, A., Właź, P., et al. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9959-2 · Cited by 54 · see citing works

Impact of Caffeine Consumption on Type 2 Diabetes-Induced Spatial Memory Impairment and Neurochemical Alterations in the Hippocampus

Duarte, J. M. N., Skoug, C., Silva, H. B. L., Carvalho, R. A., Rolf Gruetter, A., & Cunha, R. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.01015 · Cited by 54 · see citing works

Molecular mechanisms of rapid-acting antidepressants: New perspectives for developing antidepressants

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Caffeine and modafinil given during 48h sleep deprivation modulate object recognition memory and synaptic proteins in the hippocampus of the rat

Wadhwa, M., Sahu, S., Kumari, P., Kauser, H., Ray, K., & Panjwani, U. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.08.002 · Cited by 52 · see citing works

Adenosine A2A receptor inactivation alleviates early-onset cognitive dysfunction after traumatic brain injury involving an inhibition of tau hyperphosphorylation

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Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition

Oh, N. S., Joung, J. Y., Lee, J. Y., Song, J. G., Oh, S., Kim, Y., Kim, H. W., & Kim, S. H. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1756690 · Cited by 52 · see citing works

Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study

Oliveira, S. M., Ardais, A. P., Bastos, C. R., Gazal, M., Jansen, K., Souza, L. D. D. M., da Silva, R. A., Kaster, M. P., Lara, D. R., & Ghisleni, G. (2018) · Purinergic Signalling · doi:10.1007/s11302-018-9635-2 · Cited by 54 · see citing works

The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory

Li, Z., Chen, X., Wang, T., Gao, Y., Li, F. Y., Chen, L., Xue, J., He, Y., Li, Y., Guo, W. M., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.07.017 · Cited by 49 · see citing works

Novel Players in the Aging Synapse: Impact on Cognition

Temido‐Ferreira, M., Coelho, J. E., Pousinha, P. A., & Lopes, L. V. (2019) · Journal of Caffeine and Adenosine Research · doi:10.1089/caff.2019.0013 · Cited by 51 · see citing works

Whole body vibration training improves depression-like behaviors in a rat chronic restraint stress model

Peng, G., Yang, L., Wu, C., Zhang, L. L., Wu, C. Y., Fan, L., Shi, H. W., Hou, J., Zhang, L. M., Ma, X., et al. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104926 · Cited by 50 · see citing works

Glia-derived adenosine in the ventral hippocampus drives pain-related anxiodepression in a mouse model resembling trigeminal neuralgia

Lv, X., Lv, S., Wang, G., Chang, Y., Cai, Y., Liu, H.-Z., Xu, G.-Z., Xu, W., & Zhang, Y. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.01.012 · Cited by 47 · see citing works

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, M. Y. S. D., Dobrachinski, F., Silva, H. B. L., Lopes, J. P., Gonçalves, F. Q., Soares, F. A. A., Porciúncula, L. O., de Andrade, G. M., Cunha, R. A., & Tomé, Â. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-89964-0 · Cited by 47 · see citing works

Repeated cycles of binge-like ethanol exposure induce immediate and delayed neurobehavioral changes and hippocampal dysfunction in adolescent female rats

Fernandes, L. M. P., Cartágenes, S. C., Barros, M. A., Carvalheiro, T. C. V. S., Castro, N. C. F., Schamne, M. G., Lima, R. R., Prediger, R. D., Monteiro, M. C., Fontes-Júnior, E. A., et al. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.007 · Cited by 46 · see citing works

Targeting astrocytes in bipolar disorder

Peng, L., Li, B., & Verkhratsky, A. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1171144 · Cited by 46 · see citing works

Caffeine: An Overview of Its Beneficial Effects in Experimental Models and Clinical Trials of Parkinson’s Disease

Schepici, G., Silvestro, S., Bramanti, P., & Mazzon, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134766 · Cited by 47 · see citing works

Potential Therapeutic Applications of Adenosine A2AReceptor Ligands and Opportunities for A2AReceptor Imaging

van Waarde, A., Dierckx, R., Zhou, X., Khanapur, S., Tsukada, H., Ishiwata, K., Luurtsema, G., de Vries, E. F. J., & Elsinga, P. H. (2017) · Medicinal Research Reviews · doi:10.1002/med.21432 · Cited by 43 · see citing works

Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation

Mouro, F. M., Batalha, V. L., Ferreira, D. G., Coelho, J. E., Baqi, Y., Müller, C. E., Lopes, L. V., Ribeiro, J. A., & Sebastião, A. M. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.021 · Cited by 43 · see citing works

Mitochondria: A Connecting Link in the Major Depressive Disorder Jigsaw

Sharma, S., & Akundi, R. S. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180302120322 · Cited by 42 · see citing works

Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex

Kerkhofs, A., Canas, P. M., Timmerman, A., Heistek, T. S., Real, J. I., Xavier, A. C., Cunha, R. A., Mansvelder, H. D., & Ferreira, S. G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00133 · Cited by 43 · see citing works

Adenosine A2A receptor involves in neuroinflammation-mediated cognitive decline through activating microglia under acute hypobaric hypoxia

Chen, P.-Z., He, W., Zhu, Z.-R., Guoji, E., Xu, G., Chen, D., & Gao, Y. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.038 · Cited by 42 · see citing works

Signaling pathways underlying the antidepressant-like effect of inosine in mice

Gonçalves, F. M., Neis, V. B., Rieger, D. K., Lopes, M. W., Heinrich, I. A., Costa, A. P., Rodrigues, A. L. S., Kaster, M. P., & Leal, R. B. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9551-2 · Cited by 40 · see citing works

Caffeine Controls Glutamatergic Synaptic Transmission and Pyramidal Neuron Excitability in Human Neocortex

Kerkhofs, A., Xavier, A. C., da Silva, B. S., Canas, P., Idema, S., Baayen, J. C., Ferreira, S. G., Cunha, R., & Mansvelder, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00899 · Cited by 34 · see citing works

Behavioral changes induced through adenosine A2A receptor ligands in a rat depression model induced by olfactory bulbectomy

Padilla, K., Quintanar‐Stephano, A., López-Vallejo, F., Berumen, L. C., Miledi, R., & García‐Alcocer, G. (2018) · Brain and Behavior · doi:10.1002/brb3.952 · Cited by 40 · see citing works

Of adenosine and the blues: The adenosinergic system in the pathophysiology and treatment of major depressive disorder

Gomes, J. I., Farinha‐Ferreira, M., Rei, N., Gonçalves‐Ribeiro, J., Ribeiro, J. A., Sebastião, A. M., & Vaz, S. H. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105363 · Cited by 40 · see citing works

Crosstalk Between ATP-P2X7 and Adenosine A2A Receptors Controlling Neuroinflammation in Rats Subject to Repeated Restraint Stress

Dias, L., Lopes, C. R., Gonçalves, F. Q., Nunes, A. F., Pochmann, D., Machado, N. J., Tomé, Â. R., Agostinho, P. M., & Cunha, R. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.639322 · Cited by 42 · see citing works

Low dose of caffeine enhances the efficacy of antidepressants in major depressive disorder and the underlying neural substrates

Liu, Q., Deng, R., Fan, Y.-Y., Li, K., Meng, F., Li, X., & Liu, R. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600910 · Cited by 39 · see citing works

The involvement of PI3K/Akt/mTOR/GSK3β signaling pathways in the antidepressant-like effect of AZD6765

Neis, V. B., Moretti, M., da Rosa, P. B., Dalsenter, Y. D. O., Werle, I., Platt, N., Kaufmann, F. N., Rosado, A. F., Besen, M. H., & Rodrigues, A. L. S. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.173020 · Cited by 39 · see citing works

A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases

Merighi, S., Borea, P. A., Varani, K., Vincenzi, F., Jacobson, K. A., & Gessi, S. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666211129122550 · Cited by 39 · see citing works

Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis

Stazi, M., Lehmann, S., Sakib, M. S., Pena‐Centeno, T., Büschgens, L., Fischer, A., Weggen, S., & Wirths, O. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04062-8 · Cited by 39 · see citing works

Adenosine A2Areceptors facilitate synaptic NMDA currents in CA1 pyramidal neurons

Mouro, F. M., Rombo, D. M., Dias, R. B., Ribeiro, J. A., & Sebastião, A. M. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14497 · Cited by 38 · see citing works

Daily Caffeine Intake Induces Concentration-Dependent Medial Temporal Plasticity in Humans: A Multimodal Double-Blind Randomized Controlled Trial

Lin, Y.-S., Weibel, J., Landolt, H., Santini, F., Meyer, M., Brunmair, J., Meier, S. M., Gerner, C., Borgwardt, S., Cajochen, C., et al. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab005 · Cited by 32 · see citing works

Associations of Non-Alcoholic Beverages with Major Depressive Disorder History and Depressive Symptoms Clusters in a Sample of Overweight Adults

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Region‐specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

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Remedial effects of caffeine against depressive-like behaviour in mice by modulation of neuroinflammation and BDNF

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Adenosine A2A Receptor Signaling in the Immunopathogenesis of Experimental Autoimmune Encephalomyelitis

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Effects of Daily Matcha and Caffeine Intake on Mild Acute Psychological Stress-Related Cognitive Function in Middle-Aged and Older Adults: A Randomized Placebo-Controlled Study

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Metabolic syndrome causes recognition impairments and reduced hippocampal neuronal plasticity in rats

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Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

Machado, N. J., Simões, A. P., Silva, H. B. L., Ardais, A. P., Kaster, M. P., Garção, P., Rodrigues, D. I., Pochmann, D., Santos, A. I., Araújo, I. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9774-9 · Cited by 60 · see citing works

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Chronic Caffeine Consumption Prevents Memory Disturbance in Different Animal Models of Memory Decline

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Review Article Chronic Caffeine Consumption Prevents Memory Disturbance in Different Animal Models of Memory Decline

Cunha, R. A., & Agostinho, P. M. (2016)

Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress

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