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Endophilin-B regulates autophagy during synapse development and neurodegeneration

Hernandez-Diaz, Sergio, Ghimire, Saurav, Sanchez-Mirasierra, Irene, Montecinos-Oliva, Carla, Swerts, Jef, Kuenen, Sabine, Verstreken, Patrik, Soukup, Sandra-Fausia·2022·Neurobiology of Disease
DOI 10.1016/j.nbd.2021.105595
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  • LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors.

    “LRRK2 activity plays a role in synaptic vesicle endocytosis, activation of autophagy, and axonal transport of growth factor receptors [2, 7, 10, 24, 25, 36, 51, 59, 62, 75, 77, 96].”

    From Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain (2023) · cites this paper as [25]

    Section 3.4 reports that kinase-active LRRK2 G2019S increases autophagosomes at Drosophila synapses, supporting a role in autophagy. The References list studies on LRRK2 and synaptic endocytosis, but this paper does not itself establish that part of the claim. No passage found supports a role in axonal transport of growth factor receptors. (LLM, conf=0.86)

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Metadata

Authors
Hernandez-Diaz, S., Ghimire, S., Sanchez-Mirasierra, I., Montecinos-Oliva, C., Swerts, J., Kuenen, S., Verstreken, P., & Soukup, S.-F.
Venue
Neurobiology of Disease
Publisher
Elsevier BV
Published
2022-02
Volume
163
Pages
105595
ISSN
0969-9961
DOI
10.1016/j.nbd.2021.105595
Cited by
27
References
3
Language
en
Licence
Funders
  • Conseil Régional Aquitaine (18001716-18001717, ERC-2014-CoG-646671)
  • Vlaamse regering
  • Fonds Wetenschappelijk Onderzoek (ERC-2020-PoC 963639, G0B8119N)

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