Cited by 83Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

The Blood–Brain Barrier in Psychoneuroimmunology

Banks, William A.·2006·Neurologic Clinics

Abstract

The very term "psychoneuroimmunology" connotes separate compartments that interact. The BBB is the physical and physiologic dividing line between the immune system and the CNS and is the locale for interaction. Interactions between the immune system and the CNS are mediated at the BBB through a variety of mechanisms. The BBB restricts unregulated mixing of the immune substances in the blood with those in the CNS, directly transports neuroimmune active substances between the blood and the CNS, and secretes neuroimmune substances. All these normal functions of the BBB can be altered in an adaptive or pathologic manner by neuroimmune events. As such, the BBB is an important conduit in the communication of the immune and the central nervous systems.

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Crossref · 10.1016/j.ncl.2006.03.009

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  • The brain monitors peripheral innate immune responses by several parallel means, including afferent nerves, Toll-like receptors, cytokine transporters at the blood-brain barrier, and IL-1 receptors on perivascular macrophages and endothelial cells.

    “The brain monitors peripheral innate immune responses by several means that act in parallel (FIG. 1).”

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Authors
Banks, W. A.
Affiliations
St. Louis VA Medical Center (US)
Corresponding author
Banks, William A.
Venue
Neurologic Clinics
Publisher
Elsevier BV
Published
2006-08
Volume
24
Issue
3
Pages
413-419
ISSN
0733-8619 (ISSN-L)
OpenAlex
W2101299835
Cited by
83
References
18
Citations by year
2026: 3 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 3
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Locations
  • Neurologic Clinics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
blood-brain barrier, psychoneuroimmunology, neuroimmune interactions
MeSH terms
Blood-Brain Barrier, Brain, Capillary Permeability, Endothelium, Vascular, Humans, Intercellular Junctions, Lipopolysaccharides, Psychoneuroimmunology, Tumor Necrosis Factor-alpha, Cytokines, Paracrine Communication

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