The Blood–Brain Barrier in Psychoneuroimmunology
Abstract
The very term "psychoneuroimmunology" connotes separate compartments that interact. The BBB is the physical and physiologic dividing line between the immune system and the CNS and is the locale for interaction. Interactions between the immune system and the CNS are mediated at the BBB through a variety of mechanisms. The BBB restricts unregulated mixing of the immune substances in the blood with those in the CNS, directly transports neuroimmune active substances between the blood and the CNS, and secretes neuroimmune substances. All these normal functions of the BBB can be altered in an adaptive or pathologic manner by neuroimmune events. As such, the BBB is an important conduit in the communication of the immune and the central nervous systems.
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The brain monitors peripheral innate immune responses by several parallel means, including afferent nerves, Toll-like receptors, cytokine transporters at the blood-brain barrier, and IL-1 receptors on perivascular macrophages and endothelial cells.
“The brain monitors peripheral innate immune responses by several means that act in parallel (FIG. 1).”
From From inflammation to sickness and depression: when the immune system subjugates the brain (2008) · cites this paper as [13]
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- Authors
- Banks, W. A.
- Affiliations
- St. Louis VA Medical Center (US)
- Corresponding author
- Banks, William A.
- ORCID
- Banks, William A.
- Venue
- Neurologic Clinics
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 24
- Issue
- 3
- Pages
- 413-419
- ISSN
- 0733-8619 (ISSN-L)
- OpenAlex
- W2101299835
- Cited by
- 83
- References
- 18
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 7 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurologic Clinics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- blood-brain barrier, psychoneuroimmunology, neuroimmune interactions
- MeSH terms
- Blood-Brain Barrier, Brain, Capillary Permeability, Endothelium, Vascular, Humans, Intercellular Junctions, Lipopolysaccharides, Psychoneuroimmunology, Tumor Necrosis Factor-alpha, Cytokines, Paracrine Communication
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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