The blood-brain barrier and immune function and dysfunction

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

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FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

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Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

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Multiplicity of cerebrospinal fluid functions: new challenges in health and disease

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Passage of cytokines across the blood–brain barrier

Banks, W. A., Kastin, A. J., & Broadwell, R. D. (1996) · Neuroimmunomodulation · doi:10.1159/000097202 · Cited by 778 · see citing works

Chylomicrons promote intestinal absorption of lipopolysaccharides

Ghoshal, S., Witta, J., Zhong, J., de Villiers, W., & Eckhardt, E. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800156-jlr200 · Cited by 662 · see citing works

Brain-immune communication pathways

Quan, N., & Banks, W. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.05.005 · Cited by 626 · see citing works

Physiology of the cerebro-spinal fluid

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The gut-brain barrier in major depression: intestinal mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.

Maes, M. H. J., Kubera, M., & Leunis, J. (2008) · PubMed · Cited by 607 · see citing works

Cytokine-to-brain communication: A review & analysis of alternative mechanisms

Watkins, L. R., Maier, S. F., & Goehler, L. E. (1995) · Life Sciences · doi:10.1016/0024-3205(95)02047-m · Cited by 597 · see citing works

Energy intake is associated with endotoxemia in apparently healthy men

Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 588 · see citing works

Physiology of the CSF and Blood-Brain Barriers

Davson, H., & Segal, M. B. (1996) · Medical Entomology and Zoology · Cited by 576 · see citing works

ABC Transporters and the Blood-Brain Barrier

Begley, D. J. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384844 · Cited by 548 · see citing works

Blood-brain barrier transport of cytokines: a mechanism for neuropathology

Banks, W. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053381684 · Cited by 534 · see citing works

Microbial Translocation Is Associated with Increased Monocyte Activation and Dementia in AIDS Patients

Ancuta, P., Kamat, A., Kunstman, K. J., Kim, E.-Y., Autissier, P., Wurcel, A., Zaman, T., Stone, D., Mefford, M., Morgello, S., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002516 · Cited by 499 · see citing works

Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

Banks, W. A., Ortiz, L., Plotkin, S. R., & Kastin, A. J. (1991) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20576-6 · Cited by 474 · see citing works

Strategies to advance translational research into brain barriers

Neuwelt, E., Abbott, N. J., Abrey, L., Banks, W. A., Blakley, B., Davis, T., Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70326-5 · Cited by 474 · see citing works

The origin and application of experimental autoimmune encephalomyelitis

Baxter, A. G. (2007) · Nature reviews. Immunology · doi:10.1038/nri2190 · Cited by 458 · see citing works

Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions

Simpson, J. E., Newcombe, J., Cuzner, M. L., & Woodroofe, M. N. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00208-7 · Cited by 408 · see citing works

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

Quagliarello, V., Wispelwey, B., Long, W. J., & Scheld, W. M. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115140 · Cited by 372 · see citing works

Interleukin-1β in Immune Cells of the Abdominal Vagus Nerve: a Link between the Immune and Nervous Systems?

Goehler, L. E., Gaykema, R. P. A., Nguyen, K. T., Lee, J. E., Tilders, F. J. H., Maier, S. F., & Watkins, L. R. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02799.1999 · Cited by 357 · see citing works

Different receptor mechanisms mediate the pyrogenic and behavioral effects of interleukin 1.

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Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain

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Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

Zhang, R., Miller, R. G., Gascon, R., Champion, S., Katz, J., Lancero, M., Narvaez, A., Honrada, R., Ruvalcaba, D., & McGrath, M. S. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.017 · Cited by 319 · see citing works

Implications of the Blood-Brain Barrier and Its Manipulation

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A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis

Persidsky, Y., Stins, M. F., Way, D., Witte, M., Weinand, M. E., Kim, K. S., Bock, P., Gendelman, H. E., & Fiala, M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3499 · Cited by 316 · see citing works

The immune system and memory consolidation: a role for the cytokine IL-1β

Pugh, C., Fleshner, M., Watkins, L. R., Maier, S. F., & Rudy, J. W. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00048-8 · Cited by 311 · see citing works

ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines

Etienne‐Manneville, S., Manneville, J., Adamson, P., Wilbourn, B. R., Greenwood, J., & Couraud, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3375 · Cited by 298 · see citing works

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

Jaeger, L. B., Dohgu, S., Sultana, R., Lynch, J. L., Owen, J. B., Erickson, M. A., Shah, G. N., Price, T. O., Fleegal-Demotta, M. A., Butterfiled, D. A., et al. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.01.017 · Cited by 281 · see citing works

Tumor Necrosis Factor α and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier

Bauer, B., Hartz, A. M. S., & Miller, D. S. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.029512 · Cited by 275 · see citing works

A second look at the barriers of the medial basal hypothalamus

Peruzzo, B., Pastor, F., Blázquez, J. L., Schoebitz, K., Peláez, B., Amat, P., & Rodríguez, E. M. (2000) · Experimental Brain Research · doi:10.1007/s002219900289 · Cited by 273 · see citing works

Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide

Verma, S., Nakaoke, R., Dohgu, S., & Banks, W. A. (2005) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2005.10.005 · Cited by 267 · see citing works

Effect of LPS on the permeability of the blood–brain barrier to insulin

Xaio, H., Banks, W. A., Niehoff, M. L., & Morley, J. E. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03247-9 · Cited by 231 · see citing works

Adiponectin Does Not Cross the Blood-Brain Barrier but Modifies Cytokine Expression of Brain Endothelial Cells

Spranger, J., Verma, S., Göhring, I., Bobbert, T., Seifert, J., Sindler, A. L., Pfeiffer, A. F. H., Hileman, S. M., Tschöp, M. H., & Banks, W. A. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-1077 · Cited by 217 · see citing works

Nitric Oxide Synthase Activity Is Elevated in Brain Microvessels in Alzheimer′s Disease

Dorheim, M. A., Tracey, W. R., Pollock, J. S., & Grammas, P. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2716 · Cited by 216 · see citing works

Endotoxemia is Related to Systemic Inflammation and Atherosclerosis in Peritoneal Dialysis Patients

Szeto, C., Kwan, B. C., Chow, K., Lai, K., Chung, K.-Y., Leung, C., & Li, P. K. (2008) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03600807 · Cited by 215 · see citing works

TNFα Transport across the Blood–Brain Barrier Is Abolished in Receptor Knockout Mice

Pan, W., & Kastin, A. J. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7871 · Cited by 210 · see citing works

Product ion of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes

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Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats

Huber, J. D., VanGilder, R. L., & Houser, K. A. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00489.2006 · Cited by 206 · see citing works

Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor-α and Lipopolysaccharide

Hartz, A. M. S., Bauer, B., Fricker, G., & Miller, D. S. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.017954 · Cited by 203 · see citing works

Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain

Cao, C., Matsumura, K., Yamagata, K., & Watanabe, Y. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.6.r1712 · Cited by 203 · see citing works

Haemophilus influenzae lipopolysaccharide-induced blood brain barrier permeability during experimental meningitis in the rat.

Wispelwey, B., Lesse, A. J., Hansen, E. J., & Scheld, W. M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113736 · Cited by 192 · see citing works

Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-α in the Rat

Candelario‐Jalil, E., Taheri, S., Yang, Y. R., Sood, R., Grossetete, M., Estrada, E. Y., Fiebich, B. L., & Rosenberg, G. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.127035 · Cited by 191 · see citing works

HIV‐1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells

Andras, I. E., Pu, H., Deli, M. A., Nath, A., Hennig, B., & Toborek, M. J. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10762 · Cited by 189 · see citing works

TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.

Fiala, M., Looney, D. J., Stins, M. F., Way, D. D., Zhang, L., Gan, X.-H., Chiappelli, F., Schweitzer, E. S., Shapshak, P., Weinand, M. E., et al. (1997) · PubMed Central · Cited by 189 · see citing works

The Blood Brain Barrier

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HIV-1 tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain

Pu, H., Tian, J., Flora, G., Lee, Y. W., Nath, A., Hennig, B., & Toborek, M. J. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00171-4 · Cited by 179 · see citing works

TNF-α Opens a Paracellular Route for HIV-1 Invasion across the Blood-Brain Barrier

Fiala, M., Looney, D. J., Stins, M. F., Way, D. D., Zhang, L., Gan, X.-H., Chiappelli, F., Schweitzer, E. S., Shapshak, P., Weinand, M. E., et al. (1997) · Molecular Medicine · doi:10.1007/bf03401701 · Cited by 174 · see citing works

The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose

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Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei

Marvel, F. A., Chen, C.-C., Badr, N. A., Gaykema, R. P. A., & Goehler, L. E. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.09.004 · Cited by 163 · see citing works

Intravenous human interleukin-1alpha impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum.

Banks, W. A., Farr, S. A., Scola, M. E. L., & Morley, J. E. (2001) · PubMed · Cited by 161 · see citing works

HIV-1 gp120 Proteins Alter Tight Junction Protein Expression and Brain Endothelial Cell Permeability: Implications for the Pathogenesis of HIV-Associated Dementia

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Exposure of tumor necrosis factor‐α to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin

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Chapter 53: Role of the OVLT in the febrile response to circulating pyrogens

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CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis

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The Blood-Central Nervous System Barriers Actively Control Immune Cell Entry into the Central Nervous System

Engelhardt, B. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784705432 · Cited by 148 · see citing works

Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli

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Severe Periodontitis Enhances Macrophage Activation via Increased Serum Lipopolysaccharide

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Interleukin‐1 receptors on rat brain endothelial cells: a role in neuroimmune interaction?

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Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

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Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV‐1‐associated dementia

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Pro-inflammatory cytokine and chemokine release by human brain microvascular endothelial cells stimulated by Streptococcus suis serotype 2

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Effect of intravenous injection of IL-1 beta on PGE2 levels in several brain areas as determined by microdialysis

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The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity

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Diabetes, Cognitive Function, and the Blood-Brain Barrier

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Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-Brain Barrier In Vivo in an Animal Model of Multiple Sclerosis

Coisne, C., Mao, W., & Engelhardt, B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803418 · Cited by 114 · see citing works

Physiology of the Cerebrospinal Fluid.

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Entry of EGF into brain is rapid and saturable

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The microcirculation of rat circumventricular organs and pituitary gland

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Effect of endotoxin on expression of TNF receptors and transport of TNF-α at the blood-brain barrier of the rat

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Blood-brain barrier tight junctions are altered during a 72-h exposure to λ-carrageenan-induced inflammatory pain

Huber, J. D., Hau, V. S., Borg, L. K., Campos, C. R., Egleton, R. D., & Davis, T. P. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00027.2002 · Cited by 100 · see citing works

Intravenous Human Interleukin-1α Impairs Memory Processing in Mice: Dependence on Blood-Brain Barrier Transport into Posterior Division of the Septum

Banks, W. A., Farr, S. A., Scola, M. E. L., & Morley, J. E. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29260-0 · Cited by 97 · see citing works

IL-1R Signaling within the Central Nervous System Regulates CXCL12 Expression at the Blood-Brain Barrier and Disease Severity during Experimental Autoimmune Encephalomyelitis

McCandless, E. E., Budde, M. D., Lees, J. R., Dorsey, D. A., Lyng, E., & Klein, R. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802258 · Cited by 90 · see citing works

Adsorptive Endocytosis of HIV-1gp120 by Blood–Brain Barrier Is Enhanced by Lipopolysaccharide

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μ-Opioid Induction of Monocyte Chemoattractant Protein-1, RANTES, and IFN-γ-Inducible Protein-10 Expression in Human Peripheral Blood Mononuclear Cells

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Pharmacological Targeting of ICAM-1 Signaling in Brain Endothelial Cells: Potential for Treating Neuroinflammation

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Models of multiple sclerosis: new insights into pathophysiology and repair

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Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

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The role of the blood-brain barrier in HIV infection of the central nervous system

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Blood-brain barrier dysfunction in cats following recombinant interleukin-2 infusion.

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HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells

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Lipopolysaccharide Impairs Blood–Brain Barrier P-glycoprotein Function in Mice Through Prostaglandin- and Nitric Oxide-Independent Pathways

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Cocaine activates redox-regulated transcription factors and induces TNF-α expression in human brain endothelial cells

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Chronic Inflammatory Pain and the Neurovascular Unit: A Central Role for Glia in Maintaining BBB Integrity?

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TNF Activates P-Glycoprotein in Cerebral Microvascular Endothelial Cells

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Interleukin-1 induces the expression of μ opioid receptors in endothelial cells

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Quantitative assessment of blood-brain barrier permeability in multiple sclerosis using 68-Ga-EDTA and positron emission tomography.

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