Endotoxin-induced experimental systemic inflammation in humans: A model to disentangle immune-to-brain communication
Abstract
Systemic inflammation is among the most prominent and most frequently observed responses of the immune system. Over the past decades, it has become clear that inflammatory cytokines not only affect immune and metabolic functions but also cause a wide range of behavioral and mood changes. Based on experimental findings in animals and observations in clinical populations it has been hypothesized that inflammation-induced neurocognitive changes contribute to the pathophysiology of neuropsychiatric diseases. However, since certain aspects of human behavior cannot be modeled in laboratory animals, there is a need for human models of systemic inflammation. In this review, we summarize recent studies employing administration of endotoxin as a model to induce transient systemic inflammation in healthy human subjects.
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In women with insomnia disorder secondary to breast cancer, LPS-stimulated production of IL-1 and IFN in whole blood was increased from pre-to-post CBT-I treatment.
“In women with insomnia disorder secondary to breast cancer, LPS-stimulated production of IL-1 and IFN in whole blood was increased from pre-to-post CBT-I treatment (492), although whether these changes were paralleled by CBT-I-induced sleep changes was not addressed.”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [492]
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- Authors
- Schedlowski, M., Engler, H., & Grigoleit, J.-S.
- Affiliations
- Essen University Hospital (DE)
- Corresponding author
- Schedlowski, Manfred
- Venue
- Brain, Behavior, and Immunity
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 35
- Pages
- 1-8
- ISSN
- 0889-1591 (ISSN-L)
- OpenAlex
- W2036299016
- Cited by
- 195
- References
- 84
- Citations by year
- 2026: 3 · 2025: 19 · 2024: 11 · 2023: 24 · 2022: 11 · 2021: 28 · 2020: 23 · 2019: 8 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 12 · 2014: 7
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- endotoxin, systemic inflammation, neuroinflammation, inflammatory cytokines, neurocognitive changes, mood and behavior, neuropsychiatric disorders, healthy volunteers
- MeSH terms
- Endotoxins, Humans, Lipopolysaccharides, Neuroimmunomodulation, Cytokines, Models, Immunological, Endotoxemia, Illness Behavior
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