Involvement of cholinergic neuronal systems in intravenous cocaine self-administration

Smith, James E; Co, Conchita; Yin, Xinhe; Sizemore, Glen M; Liguori, Anthony; Johnson, Walter E; Martin, Thomas J

doi:10.1016/j.neubiorev.2003.11.002

Cited by 47Neurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Involvement of cholinergic neuronal systems in intravenous cocaine self-administration

Smith, James E, Co, Conchita, Yin, Xinhe, Sizemore, Glen M, Liguori, Anthony, Johnson, Walter E, Martin, Thomas J·2004·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2003.11.002

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Abstract

Recent studies suggest the participation of cholinergic neurons in the brain processes underlying reinforcement. The involvement of cholinergic neurons in cocaine self-administration has been recently demonstrated in studies using muscarinic and nicotinic agonists and antagonists, microdialysis, assessment of choline acetyltransferase activity and acetylcholine (ACh) turnover rates. The present experiment was initiated to identify subsets of cholinergic neurons involved in the brain processes that underlie cocaine self-administration by lesioning discrete populations with a selective neurotoxin. Rats were trained to self-administer cocaine and the cholinergic neurotoxin 192-IgG-saporin or vehicle was then bilaterally administered into the posterior nucleus accumbens (NAcc)-ventral pallidum (VP). The 192-IgG-saporin induced lesions resulted in a pattern of drug-intake consistent with either a shift in the dose intake relationship to the left or downward compared to sham-treated controls. A second experiment used a self-administration threshold procedure that demonstrated this lesion shifted the dose intake relationship to the left compared to the sham-vehicle treated rats. The magnitude and extent of the lesion was assessed by measuring the expression of p75 (the target for 192-IgG-saporin) and choline acetyltransferase (ChAT) in the NAcc, VP, caudate nucleus-putamen (CP) and vertical limb of the medial septal nucleus-diagonal band (MS-DB) of these rats using real time reverse transcriptase-polymerase chain reaction. Significant reductions in gene expression for p75 (a selective marker for basal forebrain cholinergic neurons) and ChAT were seen in the MS-DB and VP while only small decreases were seen in the NAcc and CP of the 192-IgG-saporin treated rats. These data indicate that the overall influence of cholinergic neurons in the MS-DB and VP are inhibitory to the processes underlying cocaine self-administration and suggest that agonists directed toward subclasses of cholinergic receptors may have efficacy as pharmacotherapeutic adjuncts for the treatment of cocaine abuse.

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Lesion of NAc cholinergic neurons increases cocaine self-administration.
“while lesion of NAc cholinergic neurons increases cocaine self-administration, as might be expected if a pause in cholinergic interneuron firing in NAc signals salience (Smith et al., 2004).”
From Acetylcholine as a Neuromodulator: Cholinergic Signaling Shapes Nervous System Function and Behavior (2012) · cites this paper as Smith et al., 2004

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Authors: Smith, J. E., Co, C., Yin, X., Sizemore, G. M., Liguori, A., Johnson, W. E., & Martin, T. J.
Affiliations: Wake Forest University Health Sciences (US)
Corresponding author: Smith, James E
ORCID: Smith, James E
Martin, Thomas J
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2004-01
Volume: 27
Issue: 8
Pages: 841-850
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2003.11.002
OpenAlex: W2067883402
Cited by: 47
References: 65
Citations by year: 2026: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2019: 2 · 2017: 3 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 4
FWCI: 2.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Abbott Laboratories
National Institute on Drug Abuse (P50DA006634, DA-00114, R01DA003628, DA 06634, DA-03628)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: cocaine self-administration, cholinergic neurons, 192 IgG-saporin, neurotoxic lesion, nucleus accumbens, ventral pallidum, choline acetyltransferase, p75 neurotrophin receptor
MeSH terms: Saporins, Acetylcholine, Animals, Antibodies, Monoclonal, Immunotoxins, Choline O-Acetyltransferase, Cocaine, Eating, Globus Pallidus, Infusions, Intravenous, Microinjections, Neurons, N-Glycosyl Hydrolases, Nucleus Accumbens, Reinforcement, Psychology, Self Administration, Cholinergic Agents, Rats, Ribosome Inactivating Proteins, Type 1

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Involvement of cholinergic neuronal systems in intravenous cocaine self-administration

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