Serotonergic modulation of the limbic system
Abstract
The limbic system is composed of cortical as well as subcortical structures, which are intimately interconnected. The resulting macrostructure is responsible for the generation and expression of motivational and affective states. Especially high levels of serotonin are found in limbic forebrain structures. Serotonin projections to these structures, which arise from serotonergic cell body groups in the midbrain, form a dense plexus of axonal processes. In many areas of the limbic system, serotonergic neurotransmission can best be described as paracrine or volume transmission, and thus serotonin is believed to play a neuromodulatory role in the brain. Serotonergic projections to limbic structures, arising primarily from the dorsal and median raphe nuclei, compose two distinct serotonergic systems differing in their topographic organization, electrophysiological characteristics, morphology, as well as sensitivity to neurotoxins and perhaps psychoactive or therapeutic agents. These differences may be extremely important in understanding the role of these two serotonergic systems in normal brain function and in mental illness. Central serotonergic neurons or receptors are targets for a variety of therapeutic agents used in the treatment of disorders of the limbic system.
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CA2 pyramidal neurons integrate synaptic input from lateral entorhinal cortex, which conveys non-spatial information, with subcortical input from the serotonergic median raphe nucleus and the hypothalamic supramammillary nucleus.
“The finding that CA2 PNs integrate synaptic input from lateral EC (which conveys non-spatial information18) with subcortical input from both the serotonergic median raphe nucleus19 and the hypothalamic supramammillary nucleus20”
From The hippocampal CA2 region is essential for social memory (2014) · cites this paper as [19]
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- Authors
- Hensler, J. G.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Hensler, Julie G.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 30
- Issue
- 2
- Pages
- 203-214
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W1996461375
- Cited by
- 319
- References
- 3
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 13 · 2023: 14 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 15 · 2018: 10 · 2017: 15 · 2016: 15 · 2015: 21 · 2014: 22 · 2013: 18 · 2012: 24
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 52369)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- serotonin, limbic system, serotonergic neurotransmission, dorsal raphe nucleus, median raphe nucleus, neuromodulation, serotonin receptors, affective states, mental illness, antidepressants
- MeSH terms
- Animals, Mental Disorders, Hippocampus, Humans, Limbic System, Neural Pathways, Serotonin
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