The role of serotonin in the regulation of patience and impulsivity
Open accessAbstract
Classic theories suggest that central serotonergic neurons are involved in the behavioral inhibition that is associated with the prediction of negative rewards or punishment. Failed behavioral inhibition can cause impulsive behaviors. However, the behavioral inhibition that results from predicting punishment is not sufficient to explain some forms of impulsive behavior. In this article, we propose that the forebrain serotonergic system is involved in "waiting to avoid punishment" for future punishments and "waiting to obtain reward" for future rewards. Recently, we have found that serotonergic neurons increase their tonic firing rate when rats await food and water rewards and conditioned reinforcer tones. The rate of tonic firing during the delay period was significantly higher when rats were waiting for rewards than for tones, and rats were unable to wait as long for tones as for rewards. These results suggest that increased serotonergic neuronal firing facilitates waiting behavior when there is the prospect of a forthcoming reward and that serotonergic activation contributes to the patience that allows rats to wait longer. We propose a working hypothesis to explain how the serotonergic system regulates patience while waiting for future rewards.
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Several studies in rodents have implicated serotonin in response inhibition.
“Several studies in rodents have implicated serotonin in response inhibition (reviewed in [66]).”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [66]
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- Authors
- Miyazaki, K., Miyazaki, K. W., & Doya, K.
- Affiliations
- Okinawa Institute of Science and Technology Graduate University (JP)
- Corresponding author
- Miyazaki, Katsuhiko
- ORCID
- Miyazaki, Katsuhiko
- Venue
- Molecular Neurobiology
- Published
- 2012-01-20
- Volume
- 45
- Issue
- 2
- Pages
- 213-224
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC3311865
- OpenAlex
- W1978481500
- Cited by
- 162
- References
- 75
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 16 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 13 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 12 · 2015: 16 · 2014: 10 · 2013: 11 · 2012: 6
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Molecular Neurobiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (24730643, 23120007)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin, patience, impulsivity, behavioral inhibition, waiting behavior, reward anticipation, punishment avoidance, serotonergic neurons, delay period
- MeSH terms
- Animals, Behavior, Brain, Humans, Impulsive Behavior, Serotonin, Rats
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