The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Frequency-modulated 50 kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect
Abstract
The evidence that frequency modulated (FM) 50 kHz ultrasonic vocalizations (USVs) reflect a positive emotional state in rats is reviewed. Positive emotional states in humans are measured by facial-vocal displays (e.g., Duchenne smiling and laughter), approach behavior, and subjective self-report of feeling states. In laboratory animals, only facial-vocal displays, along with approach behavior can be measured. FM 50 kHz USVs are uniquely elevated by hedonic stimuli and suppressed by aversive stimuli. Rates of FM 50 kHz USVs are positively correlated to the rewarding value of the eliciting stimulus. Additionally, playbacks of these vocalizations are rewarding. The neural and pharmacological substrates of 50 kHz USVs are consistent with those of human positive affective states. By experimentally eliciting FM 50 kHz USVs, the novel molecular underpinning of positive affect can be elucidated and may be similar to those in humans. In humans, positive emotional states confer resilience to depression and anxiety, as well as promote overall health. Using rough-and-tumble play induced hedonic USVs, we have identified insulin like growth factor I and the NR2B subunit of the NMDA receptor as playing a functional role in positive affective states. From this research, we have developed a promising new class of antidepressants that is entering phase II clinical trials for the treatment of depression.
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“While the field of 50 kHz call classification is relatively novel, evidence suggests that frequency-modulated calls, particularly those with a trill component, are indicative of positive affect.7,11”
From Ultrasonic Vocalization Analysis as a Novel Metric to Assess Cage Enrichment in Rats (2022) · cites this paper as [11]
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
The benefits of frequent positive affect: Does happiness lead to success?
Lyubomirsky, S., King, L., & Diener, E. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.6.803 · Cited by 7,143
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
The broaden–and–build theory of positive emotions
Fredrickson, B. L. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2004.1512 · Cited by 4,214
(1998) · Cited by 4,012
Self-citationPersonality, Culture, and Subjective Well-Being: Emotional and Cognitive Evaluations of Life
Diener, E., Oishi, S., & Lucas, R. E. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.54.101601.145056 · Cited by 3,802
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766
Olds, J., & Milner, P. (1954) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0058775 · Cited by 3,176
Blood, A. J., & Zatorre, R. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191355898 · Cited by 2,814
Fredrickson, B. L., Tugade, M. M., Waugh, C. E., & Larkin, G. R. (2003) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.84.2.365 · Cited by 2,797
Research works printed but not linked: 3
- Burgdorf, 2010, The antidepressant and anxiolytic properties of GLYX-13: a novel NMDA receptor glycine site functional partial agonist, Society for Neuroscience Abstract, 572.23
- Knutson, 2002, Anticipation of increasing monetary reward selectively recruits nucleus accumbens, J. Neurosci., 22, 3303
- Sheldon, K., Kashdan, T., Steger, M., (Eds.), in press. Designing the Future of Positive Psychology: Taking Stock and Moving Forward. Oxford University Press.
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Toward a second-person neuroscience
Schilbach, L., Timmermans, B., Reddy, V., Costall, A., Bente, G., Schlicht, T., & Vogeley, K. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12000660 · Cited by 1,510
The many faces of insulin-like peptide signalling in the brain
Fernandez, A. M., & Torres-Alemán, I. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3209 · Cited by 872
The power of play: A pediatric role in enhancing development in young children
Yogman, M., Garner, A., Hutchinson, J., Hirsh-Pasek, K., Golinkoff, R. M., COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, & COUNCIL ON COMMUNICATIONS AND MEDIA (2018) · Pediatrics · doi:10.1542/peds.2018-2058 · Cited by 758
The basic emotional circuits of mammalian brains: Do animals have affective lives?
Panksepp, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.08.003 · Cited by 588
Self-citationVocal expression of emotions in mammals: mechanisms of production and evidence
Briefer, E. F. (2012) · Journal of Zoology · doi:10.1111/j.1469-7998.2012.00920.x · Cited by 541
Metadata
- Authors
- Burgdorf, J., Panksepp, J., & Moskal, J. R.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Burgdorf, Jeffrey
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 35
- Issue
- 9
- Pages
- 1831-1836
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2052667603
- Cited by
- 258
- References
- 101
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 6 · 2023: 13 · 2022: 8 · 2021: 14 · 2020: 16 · 2019: 24 · 2018: 27 · 2017: 12 · 2016: 15 · 2015: 25 · 2014: 19 · 2013: 28 · 2012: 16
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Vocal Communication and Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ultrasonic vocalizations, 50-kHz vocalizations, positive affect, rats, rough-and-tumble play, insulin-like growth factor I, NR2B subunit, antidepressants, depression, reward, aversive stimuli, neural substrates of emotion
- MeSH terms
- Affect, Animals, Brain, Breeding, Humans, Male, Molecular Biology, Social Isolation, Ultrasonics, Vocalization, Animal, Rats, Long-Evans, Rats, Pleasure
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