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Frequency-modulated 50 kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect

Burgdorf, Jeffrey, Panksepp, Jaak, Moskal, Joseph R.·2011·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2010.11.011

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Abstract

The evidence that frequency modulated (FM) 50 kHz ultrasonic vocalizations (USVs) reflect a positive emotional state in rats is reviewed. Positive emotional states in humans are measured by facial-vocal displays (e.g., Duchenne smiling and laughter), approach behavior, and subjective self-report of feeling states. In laboratory animals, only facial-vocal displays, along with approach behavior can be measured. FM 50 kHz USVs are uniquely elevated by hedonic stimuli and suppressed by aversive stimuli. Rates of FM 50 kHz USVs are positively correlated to the rewarding value of the eliciting stimulus. Additionally, playbacks of these vocalizations are rewarding. The neural and pharmacological substrates of 50 kHz USVs are consistent with those of human positive affective states. By experimentally eliciting FM 50 kHz USVs, the novel molecular underpinning of positive affect can be elucidated and may be similar to those in humans. In humans, positive emotional states confer resilience to depression and anxiety, as well as promote overall health. Using rough-and-tumble play induced hedonic USVs, we have identified insulin like growth factor I and the NR2B subunit of the NMDA receptor as playing a functional role in positive affective states. From this research, we have developed a promising new class of antidepressants that is entering phase II clinical trials for the treatment of depression.

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Authors: Burgdorf, J., Panksepp, J., & Moskal, J. R.
Affiliations: Northwestern University (US)
Corresponding author: Burgdorf, Jeffrey
ORCID: Burgdorf, Jeffrey
Moskal, Joseph R.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2011-10
Volume: 35
Issue: 9
Pages: 1831-1836
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2010.11.011
OpenAlex: W2052667603
Cited by: 258
References: 101
Citations by year: 2026: 13 · 2025: 13 · 2024: 6 · 2023: 13 · 2022: 8 · 2021: 14 · 2020: 16 · 2019: 24 · 2018: 27 · 2017: 12 · 2016: 15 · 2015: 25 · 2014: 19 · 2013: 28 · 2012: 16
FWCI: 1.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Vocal Communication and Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: ultrasonic vocalizations, 50-kHz vocalizations, positive affect, rats, rough-and-tumble play, insulin-like growth factor I, NR2B subunit, antidepressants, depression, reward, aversive stimuli, neural substrates of emotion
MeSH terms: Affect, Animals, Brain, Breeding, Humans, Male, Molecular Biology, Social Isolation, Ultrasonics, Vocalization, Animal, Rats, Long-Evans, Rats, Pleasure

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Frequency-modulated 50 kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect

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