Mild traumatic brain injury: a risk factor for neurodegeneration
Open accessAbstract
Recently, it has become clear that head trauma can lead to a progressive neurodegeneration known as chronic traumatic encephalopathy. Although the medical literature also implicates head trauma as a risk factor for Alzheimer's disease, these findings are predominantly based on clinical diagnostic criteria that lack specificity. The dementia that follows head injuries or repetitive mild trauma may be caused by chronic traumatic encephalopathy, alone or in conjunction with other neurodegenerations (for example, Alzheimer's disease). Prospective longitudinal studies of head-injured individuals, with neuropathological verification, will not only improve understanding of head trauma as a risk factor for dementia but will also enhance treatment and prevention of a variety of neurodegenerative diseases.
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A history of mTBI is associated with an increased risk of being diagnosed with dementia and/or a neurodegenerative disease.
“a history of mTBI has been associated with an increased risk of being diagnosed with dementia and/or a neurodegenerative disease [36, 44, 90]”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [44]
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Top-Cited Articles in Traumatic Brain Injury
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- Authors
- Gavett, B. E., Stern, R. A., Cantu, R. C., Nowinski, C. J., & McKee, A. C.
- Affiliations
- Boston University (US)
- Corresponding author
- McKee, Ann C
- Venue
- Alzheimer's Research & Therapy
- Published
- 2010
- Volume
- 2
- Issue
- 3
- Pages
- 18
- ISSN
- 1758-9193 (ISSN-L)
- PMC
- PMC2919698
- OpenAlex
- W2038425717
- Cited by
- 216
- References
- 17
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 12 · 2023: 10 · 2022: 13 · 2021: 10 · 2020: 11 · 2019: 18 · 2018: 18 · 2017: 17 · 2016: 16 · 2015: 19 · 2014: 19 · 2013: 18 · 2012: 11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Alzheimer s Research & Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Operating Committee on Standards for Athletic Equipment
- National Institute on Aging (0572063345–5, 0572063345, supplement 0572063345, P30-AG13846))
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- mild traumatic brain injury, chronic traumatic encephalopathy, neurodegeneration, Alzheimer's disease, head trauma, dementia risk factors, repetitive head injury, neuropathology
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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