Cue-Induced Craving Increases Impulsivity via Changes in Striatal Value Signals in Problem Gamblers
Open accessAbstract
Impulsive behavior such as steep temporal discounting is a hallmark of addiction and is associated with relapse. In pathological gamblers, discounting may be further increased by the presence of gambling-related cues in the environment, but the extent to which the gambling relatedness of task settings affects reward responses in gambling addiction is debated. In the present study, human problem gamblers made choices between immediate rewards and individually tailored larger-but-later rewards while visual gambling-related scenes were presented in the background.N= 17 participants were scanned using fMRI, whereas N= 5 additional participants completed a behavioral version of the task. Postscan craving ratings were acquired for each image, and behavioral and neuroimaging data were analyzed separately for high- and low-craving trials (median split analysis). Discounting was steeper for high versus low craving trials. Neuroimaging revealed a positive correlation with model-based subjective value in midbrain and striatum in low-craving trials that was reversed in high-craving trials. These findings reveal a modulation of striatal reward responses in gamblers by addiction-related cues, and highlight a potentially important mechanism that may contribute to relapse. Cue-induced changes in striatal delayed reward signals may lead to increased discounting of future rewards, which might in turn affect the likelihood of relapse.
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In humans, individuals that abuse cocaine or alcohol show abnormally high dopaminergic activity in the ventral striatum and elevated self-reported craving in response to drug-related cues.
“In humans, studies show that individuals that abuse cocaine or alcohol show abnormally high dopaminergic activity in the ventral striatum and elevated self-reported craving in response to drug-related cues (Heinz et al., 2014; Miedl, Büchel, & Peters, 2014; Volkow et al., 2006).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Miedl, Büchel, & Peters, 2014
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Self-citation
- Authors
- Miedl, S. F., Büchel, C., & Peters, J.
- Affiliations
- University of Salzburg (AT)
- University Medical Center Hamburg-Eppendorf (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-03-26
- Volume
- 34
- Issue
- 13
- Pages
- 4750-4755
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6608125
- OpenAlex
- W1976261289
- Cited by
- 87
- References
- 50
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 2 · 2023: 10 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 10 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 5
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- problem gambling, cue-induced craving, impulsivity, delay discounting, delayed rewards, midbrain, relapse, addiction
- MeSH terms
- Adult, Computer Simulation, Corpus Striatum, Cues, Gambling, Humans, Image Processing, Computer-Assisted, Impulsive Behavior, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Reward, Behavior, Addictive
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