Cited by 133Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Neurobiological markers predicting treatment response in anxiety disorders: A systematic review and implications for clinical application

Lueken, Ulrike, Zierhut, Kathrin C., Hahn, Tim, Straube, Benjamin, Kircher, Tilo, Reif, Andreas, Richter, Jan, Hamm, Alfons +2 more·2016·Neuroscience & Biobehavioral Reviews

Abstract

Anxiety disorders constitute the largest group of mental disorders with a high individual and societal burden. Neurobiological markers of treatment response bear potential to improve response rates by informing stratified medicine approaches. A systematic review was performed on the current evidence of the predictive value of genetic, neuroimaging and other physiological markers for treatment response (pharmacological and/or psychotherapeutic treatment) in anxiety disorders. Studies published until March 2015 were selected through search in PubMed, Web of Science, PsycINFO, Embase, and CENTRAL. Sixty studies were included, among them 27 on genetic, 17 on neuroimaging and 16 on other markers. Preliminary evidence was found for the functional 5-HTTLPR/rs25531 genotypes, anterior cingulate cortex function and cardiovascular flexibility to modulate treatment outcome. Studies varied considerably in methodological quality. Application of more stringent study methodology, predictions on the individual patient level and cross-validation in independent samples are recommended to set the next stage of biomarker research and to avoid flawed conclusions in the emerging field of "Mental Health Predictomics".

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Crossref · 10.1016/j.neubiorev.2016.04.005

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  • At present, none of the putative blood-based, genetic, epigenetic, neurochemical, metabolic or neuroimagery biomarkers are sufficiently specific, valid and reliable as diagnostic tools or markers of treatment response in anxiety disorders.

    “none of the putative blood-based, genetic, epigenetic, neurochemical, metabolic or neuroimagery biomarkers are sufficiently specific, valid and reliable as diagnostic tools or markers of treatment response in anxiety disorders (Bandelow et al., 2016;Lueken et al., 2016;Maron et al., 2018)”

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Authors
Lueken, U., Zierhut, K. C., Hahn, T., Straube, B., Kircher, T., Reif, A., Richter, J., Hamm, A., Wittchen, H.-U., & Domschke, K.
Affiliations
  • Universitätsklinikum Würzburg (DE)
  • Goethe University Frankfurt (DE)
  • Philipps University of Marburg (DE)
  • Universität Greifswald (DE)
Corresponding author
Lueken, Ulrike
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2016-07
Volume
66
Pages
143-162
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2346528861
Cited by
133
References
119
Citations by year
2026: 6 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 10 · 2021: 17 · 2020: 18 · 2019: 15 · 2018: 12 · 2017: 16 · 2016: 2
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Jürgen Deckert
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
anxiety disorders, treatment response prediction, neurobiological biomarkers, genetic markers, 5-HTTLPR, rs25531, anterior cingulate cortex, cardiovascular reactivity, pharmacotherapy, psychotherapy, stratified medicine
MeSH terms
Anxiety Disorders, Humans, Biomarkers, Treatment Outcome

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