Neurobiological markers predicting treatment response in anxiety disorders: A systematic review and implications for clinical application
Abstract
Anxiety disorders constitute the largest group of mental disorders with a high individual and societal burden. Neurobiological markers of treatment response bear potential to improve response rates by informing stratified medicine approaches. A systematic review was performed on the current evidence of the predictive value of genetic, neuroimaging and other physiological markers for treatment response (pharmacological and/or psychotherapeutic treatment) in anxiety disorders. Studies published until March 2015 were selected through search in PubMed, Web of Science, PsycINFO, Embase, and CENTRAL. Sixty studies were included, among them 27 on genetic, 17 on neuroimaging and 16 on other markers. Preliminary evidence was found for the functional 5-HTTLPR/rs25531 genotypes, anterior cingulate cortex function and cardiovascular flexibility to modulate treatment outcome. Studies varied considerably in methodological quality. Application of more stringent study methodology, predictions on the individual patient level and cross-validation in independent samples are recommended to set the next stage of biomarker research and to avoid flawed conclusions in the emerging field of "Mental Health Predictomics".
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At present, none of the putative blood-based, genetic, epigenetic, neurochemical, metabolic or neuroimagery biomarkers are sufficiently specific, valid and reliable as diagnostic tools or markers of treatment response in anxiety disorders.
“none of the putative blood-based, genetic, epigenetic, neurochemical, metabolic or neuroimagery biomarkers are sufficiently specific, valid and reliable as diagnostic tools or markers of treatment response in anxiety disorders (Bandelow et al., 2016;Lueken et al., 2016;Maron et al., 2018)”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Lueken et al., 2016
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- Authors
- Lueken, U., Zierhut, K. C., Hahn, T., Straube, B., Kircher, T., Reif, A., Richter, J., Hamm, A., Wittchen, H.-U., & Domschke, K.
- Affiliations
- Universitätsklinikum Würzburg (DE)
- Goethe University Frankfurt (DE)
- Philipps University of Marburg (DE)
- Universität Greifswald (DE)
- Corresponding author
- Lueken, Ulrike
- ORCID
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 66
- Pages
- 143-162
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2346528861
- Semantic Scholar
- 2e6bb35c188aa698fa92d2928245c606cac9b8e0
- Cited by
- 133
- References
- 119
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 10 · 2021: 17 · 2020: 18 · 2019: 15 · 2018: 12 · 2017: 16 · 2016: 2
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jürgen Deckert
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- anxiety disorders, treatment response prediction, neurobiological biomarkers, genetic markers, 5-HTTLPR, rs25531, anterior cingulate cortex, cardiovascular reactivity, pharmacotherapy, psychotherapy, stratified medicine
- MeSH terms
- Anxiety Disorders, Humans, Biomarkers, Treatment Outcome
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