Genetics of generalized anxiety disorder and related traits

Diagnostic and Statistical Manual of Mental Disorders

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Epidemiology of anxiety disorders in the 21st century

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A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety Disorders

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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

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Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits

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A Population-Based Twin Study of the Relationship Between Neuroticism and Internalizing Disorders

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Meta-analysis of genome-wide association studies of anxiety disorders

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The Structure of Genetic and Environmental Risk Factors for Anxiety Disorders in Men and Women

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A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety.

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Genetic variation in human NPY expression affects stress response and emotion

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Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder

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Structure and Etiology of Co-Occurring Internalizing and Externalizing Disorders in Adolescents

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5‐HTTLPR genotype and anxiety‐related personality traits: A meta‐analysis and new data

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Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism

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Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci

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Genetic and Environmental Sources of Covariation Between Generalized Anxiety Disorder and Neuroticism

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The Phenotypic and Genetic Structure of Depression and Anxiety Disorder Symptoms in Childhood, Adolescence, and Young Adulthood

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Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder

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A twin study of generalized anxiety disorder symptoms, panic disorder symptoms and post-traumatic stress disorder in men

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Elevated Cortisol in Older Adults With Generalized Anxiety Disorder Is Reduced by Treatment: A Placebo-Controlled Evaluation of Escitalopram

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Neurobiological markers predicting treatment response in anxiety disorders: A systematic review and implications for clinical application

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Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Anxiety Reactivity in Daily Life: A Daily Process Approach to Gene-Environment Interaction

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The BDNF Val66Met polymorphism and anxiety: Support for animal knock-in studies from a genetic association study in humans

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Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression

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5-HTTLPR moderates effects of current life events on neuroticism: Differential susceptibility to environmental influences

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Association between dopamine D4 receptor (DRD4) exon III polymorphism and Neuroticism in the Japanese population

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Pilot multimodal twin imaging study of generalized anxiety disorder

Hettema, J. M., Kettenmann, B., Ahluwalia, V., McCarthy, C., Kates, W. R., Schmitt, J. E., Silberg, J. L., Neale, M. C., Kendler, K. S., & Fatouros, P. P. (2011) · Depression and Anxiety · doi:10.1002/da.20901 · Cited by 91 · see citing works

Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder

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RGS2and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults

Koenen, K. C., Amstadter, A. B., Ruggiero, K. J., Acierno, R. E., Galea, S., Kilpatrick, D. G., & Gelernter, J. E. (2008) · Depression and Anxiety · doi:10.1002/da.20528 · Cited by 84 · see citing works

Moderation of the association between childhood maltreatment and neuroticism by the corticotropin‐releasing hormone receptor 1 gene

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The boundaries of the internalizing and externalizing genetic spectra in men and women

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Making sense of epigenetics

Schuebel, K., Gitik, M., Domschke, K., & Goldman, D. (2016) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw058 · Cited by 75 · see citing works

Serotonin transporter gene and childhood trauma - a G × E effect on anxiety sensitivity

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Shared genetic contributions to anxiety disorders and pathological gambling in a male population

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Novel developments in genetic and epigenetic mechanisms of anxiety

Gottschalk, M. G., & Domschke, K. (2015) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000219 · Cited by 70 · see citing works

The interaction of early life experiences with COMT val158met affects anxiety sensitivity

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Neuropeptide S receptor gene (NPSR) and life events: G × E effects on anxiety sensitivity and its subdimensions

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Influence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study

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Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety

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NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults

Amstadter, A. B., Koenen, K. C., Ruggiero, K. J., Acierno, R. E., Galea, S., Kilpatrick, D. G., & Gelernter, J. E. (2009) · Depression and Anxiety · doi:10.1002/da.20648 · Cited by 55 · see citing works

Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder

Lohoff, F. W., Aquino, T. D., Narasimhan, S., Multani, P. K., Etemad, B., & Rickels, K. (2011) · The Pharmacogenomics Journal · doi:10.1038/tpj.2011.47 · Cited by 53 · see citing works

A Twin Study of Lifetime Generalized Anxiety Disorder (GAD) in Older Adults: Genetic and Environmental Influences Shared by Neuroticism and GAD

Mackintosh, M., Gatz, M., Wetherell, J. L., & Pedersen, N. L. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706776402902 · Cited by 53 · see citing works

Genome‐wide association study of generalized anxiety symptoms in the Hispanic Community Health Study/Study of Latinos

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BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder

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Interaction of the neuropeptide S receptor gene Asn107Ile variant and environment: contribution to affective and anxiety disorders, and suicidal behaviour

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The Met allele of BDNF Val66Met polymorphism is associated with increased BDNF levels in generalized anxiety disorder

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Gender-specific association between serotonin transporter polymorphisms ( 5-HTTLPR and rs25531 ) and neuroticism, anxiety and depression in well-defined healthy Han Chinese

Chang, C.-C., Chang, H., Fang, W., Chang, T.-C., & Huang, S. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.08.055 · Cited by 46 · see citing works

Interaction between polymorphisms in serotonin transporter (SLC6A4) and serotonin receptor 2A (HTR2A) genes predict treatment response to venlafaxine XR in generalized anxiety disorder

Lohoff, F. W., Narasimhan, S., & Rickels, K. (2012) · The Pharmacogenomics Journal · doi:10.1038/tpj.2012.33 · Cited by 44 · see citing works

Making sense of deep sequencing

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Generalized anxiety disorder and anorexia nervosa: evidence of shared genetic variation

Dellava, J. E., Kendler, K. S., & Neale, M. C. (2011) · Depression and Anxiety · doi:10.1002/da.20834 · Cited by 42 · see citing works

A Twin Study of Lifetime Generalized Anxiety Disorder (GAD) in Older Adults: Genetic and Environmental Influences Shared by Neuroticism and GAD

Mackintosh, M., Gatz, M., Wetherell, J. L., et al. (2006) · Twin Research and Human Genetics · doi:10.1375/twin.9.1.30 · Cited by 39 · see citing works

5-HTTLPR/rs25531 polymorphism and neuroticism are linked by resting state functional connectivity of amygdala and fusiform gyrus

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Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes

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Association study of monoamine oxidase-A gene promoter polymorphism (MAOA-uVNTR) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents

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Pharmacogenetic investigation of response to duloxetine treatment in generalized anxiety disorder

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Relation of Serotonin Transporter Genetic Variation to Efficacy of Escitalopram for Generalized Anxiety Disorder in Older Adults

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A population-based family study of DSM-III generalized anxiety disorder

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Variation in the catechol-O-methyltransferase (COMT) gene and treatment response to venlafaxine XR in generalized anxiety disorder

Narasimhan, S., Aquino, T. D., Multani, P. K., Rickels, K., & Lohoff, F. W. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.034 · Cited by 28 · see citing works

Association of a functional variant of the nitric oxide synthase 1 gene with personality, anxiety, and depressiveness

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An Underlying Common Factor, Influenced by Genetics and Unique Environment, Explains the Covariation Between Major Depressive Disorder, Generalized Anxiety Disorder, and Burnout: A Swedish Twin Study

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A genome-wide linkage study of individuals with high scores on NEO personality traits

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Association analysis between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and treatment response to venlafaxine XR in generalized anxiety disorder

Narasimhan, S., Aquino, T. D., Hodge, R., Rickels, K., & Lohoff, F. W. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.035 · Cited by 23 · see citing works

Escitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2A and 1B receptors

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Affective Neural Responses Modulated by Serotonin Transporter Genotype in Clinical Anxiety and Depression

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Serotonin transporter andBDNFpolymorphisms interact to predict trait worry

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Lack of influence ofDAT1andDRD2gene variants on antidepressant response in generalized anxiety disorder

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Converging evidence for an impact of a functionalNOSgene variation on anxiety-related processes

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Stressing over anxiety: A novel interaction of 5-HTTPLR genotype and anxiety-related phenotypes in older adults

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Preventive psychiatry: a blueprint for improving the mental health of young people

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Candidate biomarkers in psychiatric disorders: state of the field

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Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

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Association between fecal microbiota and generalized anxiety disorder: Severity and early treatment response

Chen, Y.-H., Bai, J., Wu, D., Yu, S.-F., Qiang, X.-L., Bai, H., Wang, H., & Peng, Z. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.014 · Cited by 225 · see citing works

Associations between paternal versus maternal parenting behaviors and child and adolescent internalizing problems: A systematic review and meta-analysis

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Proteolytic cleavage of proBDNF to mBDNF in neuropsychiatric and neurodegenerative diseases

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Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

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Endocannabinoids, cannabinoids and the regulation of anxiety

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Relationship between Early Maladaptive Schemas and Anxiety in Adolescence and Young Adulthood: A systematic review and meta-analysis

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Heart rate variability: Evaluating a potential biomarker of anxiety disorders

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Aberrant amplitude low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) in generalized anxiety disorder (GAD) and their roles in predicting treatment remission

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The roles of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in predicting treatment remission in a Chinese Han population with generalized anxiety disorder

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Translational Studies in the Complex Role of Neurotransmitter Systems in Anxiety and Anxiety Disorders

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An animal model of trait anxiety: Carioca high freezing rats as a model of generalized anxiety disorder

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Untangling the associations between generalized anxiety and body dissatisfaction: The mediating effects of social physique anxiety among collegiate men and women

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Childhood Adoption and Mental Health in Adulthood: The Role of Gene-Environment Correlations and Interactions in the UK Biobank

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Causal role of immune cells in generalized anxiety disorder: Mendelian randomization study

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Pharmacogenomic assessment of herbal drugs in affective disorders

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Automated anxiety detection using probabilistic binary pattern with ECG signals

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Severe Pain in Chronic Pancreatitis Patients: Considering Mental Health and Associated Genetic Factors

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The Slack Channel Regulates Anxiety-Like Behaviors via Basolateral Amygdala Glutamatergic Projections to Ventral Hippocampus

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SIRT1 accelerates the progression of activity-based anorexia

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Herbal medicines and botanicals for managing insomnia, stress, anxiety, and depression: A critical review of the emerging evidence focusing on the Middle East and Africa

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Is catechol‐O‐methyltransferase gene associated with temporomandibular disorders? A systematic review and meta‐analysis

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Pain Experience in Pancreatitis: Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain

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National tests and the wellbeing of primary school pupils: new evidence from the UK

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Effects of visual aid on state anxiety, fear and stress level in patients undergoing endoscopy: a randomized controlled trial

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Neuroplastin in Neuropsychiatric Diseases

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Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours

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Relationship between intestinal flora, inflammation, BDNF gene polymorphism and generalized anxiety disorder: A clinical investigation

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Association and Familial Coaggregation of Childhood-Onset Type 1 Diabetes With Depression, Anxiety, and Stress-Related Disorders: A Population-Based Cohort Study

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Oxidative Stress Markers Predict Treatment Outcomes in Patients with Generalized Anxiety Disorder Treated with Selective Serotonin Reuptake Inhibitors

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The role of BDNF methylation and Val66Met in amygdala reactivity during emotion processing

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A Cross‐Sectional Network Analysis Study Applied to the Depression Anxiety Stress Scale‐21 (DASS‐21): A New Factor Revealed

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Precision TMS through the integration of neuroimaging and machine learning: optimizing stimulation targets for personalized treatment

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Novel investigational therapeutics for generalized anxiety disorder (GAD)

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Is there an association of genetic polymorphisms of the catechol-O-methyltransferase gene (rs165656 and rs174675) and the 5-hydroxytryptamine receptor 2A gene (rs4941573 and rs6313) with sleep bruxism in individuals with obstructive sleep apnea?

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RGS2 drives male aggression in mice via the serotonergic system

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Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

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Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

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Egr1 is a sex-dependent regulator of neuronal chromatin, structural plasticity, and behaviour

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Higher Anxiety Is Associated with Lower Cardiovascular Autonomic Function in Female Twins

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Interactions between Personality, Depression, Anxiety and Cognition to Understand Early Stage of Alzheimer’s Disease

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Sleep Bruxism Self‐Report and Awake Bruxism: An Ecological Momentary Assessment

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Gene–environment interaction study on the polygenic risk score for neuroticism, childhood adversity, and parental bonding

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The Mediating Effects of Diabetes Distress, Anxiety, and Cognitive Fusion on the Association Between Neuroticism and Fear of Hypoglycemia in Patients With Type 2 Diabetes

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Gene expression and epigenetic changes in post-traumatic stress disorder, depression, and anxiety in first responders: A systematic review

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Effect of different factors on patient perception of surgical discomfort in third molar surgery

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Heterosis in COMT Val158Met Polymorphism Contributes to Sex-Differences in Children’s Math Anxiety

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Anxiolytic effect of Korean Red Ginseng through upregulation of serotonin and GABA transmission and BDNF expression in immobilized mice

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Dynamic effective connectivity among large‐scale brain networks mediates risk of anxiety

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Prenatal tobacco and alcohol exposures and the risk of anxiety symptoms in young adulthood: A population-based cohort study

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Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder

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Animal-to-Human Translation Difficulties and Problems With Proposed Coding-in-Noise Deficits in Noise-Induced Synaptopathy and Hidden Hearing Loss

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BNC210: an investigational α7-nicotinic acetylcholine receptor modulator for the treatment of anxiety disorders

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Risk for internalizing symptom development in young children: Roles of child parasympathetic reactivity and maternal depression and anxiety exposure in early life

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Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats

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Critical appraisal and systematic review of genes linked with cocaine addiction, depression and anxiety

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Pharmacogenetics of anxiety disorders

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The Value of Neuroimaging Techniques in the Translation and Transdiagnostic Validation of Psychiatric Diagnoses - Selective Review

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The “conflict avoidance theory of inflammation-induced anxiety” (CATIA): A psychoneuroimmunologic hypothesis

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The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

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Somatic masks of anxiety disorder and therapy opportunities

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The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows

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Number of Pain Locations as a Predictor of Cause-Specific Disability Pension in Sweden-Do Common Mental Disorders Play a Role?

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Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity

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Inhibition of adult neurogenesis reduces avoidance behavior in male, but not female, mice subjected to early life adversity

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Serotonergic influence on depressive symptoms and trait anxiety is mediated by negative life events and frontal activation in children and adolescents

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A systematic review of methylome-wide associations with anxiety disorders

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Generalized Anxiety Disorder: A Review of Current Literature in Saudi Arabia

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Predicting anxiety and depression over 12 months of the COVID‐19 pandemic: A machine learning study

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Living and neighborhood environments and anxiety symptoms among older adults in Anhui, China: evidence from a cross-sectional study

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Hypnotherapy for agoraphobia—Feasibility and efficacy investigated in a pilot study

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Age-dependent association of polymorphisms in the promoter and 5′-untranslated region of the norepinephrine transporter gene with generalized anxiety disorder

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Childhood Trauma Predicts Less Remission from PTSD among Patients with Co-Occurring Alcohol Use Disorder and PTSD

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Mental health: Sex and gender evidence in depression, generalized anxiety disorder, and schizophrenia

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Prevalence of Common Alleles of Some Stress Resilience Genes among Adolescents Born in Different Periods Relative to the Socioeconomic Crisis of the 1990s in Russia

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Development and evaluation of an internet-based treatment for generalized anxiety disorder : An acceptance-based approach

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Topic modeling and content analysis of people’s anxiety-related concerns raised on a computer-mediated health platform

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Genetische Grundlagen der Posttraumatischen Belastungsstörung (PTBS)

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Reduced Blood RGS2 Expression in Mild Cognitive Impairment Patients

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Addressing systemic racism and intergenerational transmission of anxiety using Bowenian family therapy with African American populations: A Discursive paper

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Spatiotemporal expression patterns of anxiety disorder-associated genes

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Childhood abuse/neglect and temporal patterns in late-life anxiety

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Lifetime caffeine and adolescent nicotine exposure in mice: effects on anxiety-like behavior and reward

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GENETICS OF GENERALIZED ANXIETY DISORDER

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