Clock genes, ADHD and aggression
Open accessAbstract
Attention deficit/hyperactivity disorder (ADHD) is frequently associated with comorbid aggression and sleep disturbances. The sleep/wake cycle is under the control of the circadian system which is moderated by clock genes. Clock genes can regulate the transcription of monoamine oxidase A, which is involved in the degradation of monoamines. Disturbances in monoamine interaction with clock genes in those with monoamine gene polymorphisms may regulate susceptibility of ADHD and comorbid aggression/sleep disturbances. While monoamines influence circadian rhythm and clock gene expression, circadian rhythm components modulate aggressive behavior, and altered clock genes expression have been associated with ADHD. We propose a mechanism by which circadian rhythm and clock gene expression may influence ADHD and comorbid aggression through the modulation of neurotransmitters. The role of clock genes in ADHD patients with comorbid aggression awaits further research; therefore we also indicate directions for future studies to help increase understanding of the underlying mechanisms in ADHD with comorbid aggression and sleep disturbances.
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Mutations in CLOCK gene have been associated with ADHD, indicating that disrupted circadian pathways could exacerbate the symptoms of this disease, including ADHD-associated aggressiveness symptoms.
“Mutations in CLOCK gene have been associated with ADHD, indicating that the disrupted circadian pathways could exacerbate the symptoms of this disease [113], including ADHD-associated aggressiveness symptoms [115].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [115]
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“Mutations in CLOCK gene have been associated with ADHD, indicating that the disrupted circadian pathways could exacerbate the symptoms of this disease [113], including ADHDassociated aggressiveness symptoms [115].”
Background
- Authors
- Mogavero, F., Jager, A., & Glennon, J. C.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Mogavero, Floriana
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 91
- Pages
- 51-68
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2551584933
- Cited by
- 44
- References
- 15
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 4
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- European Community’s Seventh Framework Programme (278948, 602805, 603016)
- European Community’s Horizon 2020 Programme (667302)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- clock genes, attention deficit hyperactivity disorder, aggression, conduct disorder, sleep disorders, circadian rhythm, monoamine oxidase A, monoamines
- MeSH terms
- Aggression, Animals, Attention Deficit Disorder with Hyperactivity, Humans, Sleep Wake Disorders, Comorbidity, Neurotransmitter Agents, Circadian Clocks
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