COMT Val158Met Genotype as a Risk Factor for Problem Behaviors in Youth
Open accessAbstract
Objective To test the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and both aggressive behavior and attention problems in youth. We hypothesized that youth carrying a Met allele would have greater average aggressive behavior scores, and that youth exhibiting Val-homozygosity would have greater average attention problems scores.Method Complete data on maternally rated Child Behavior Checklist (CBCL) measures of aggressive behavior (AGG) and attention problems (AP), COMT polymorphism data, demographics, and maternal parenting quality were available for 149 youth (6 to 18 years old). Multivariable linear regression models were used to test the degree to which youth COMT Val158Met genotype was associated with AGG and AP while statistically controlling for age, gender, parental socioeconomic status (SES), and maternal parenting quality from the Alabama Parenting Questionnaire.Results Mothers of Met-carriers rated their children higher on average AGG scores when compared with mothers of Val-homozygotes (p = .016). Further analyses revealed that this association was even more robust for maternal ratings of direct aggression (p = .007). The hypothesized association between Val-homozygosity and higher average AP scores relative to average AP scores of Met-carriers did not quite reach statistical significance (p = .062).Conclusions After controlling for demographics, SES, and maternal parenting quality as confounders, there remains a strong association between youth carrying a Met allele and higher average AGG scores relative to Val-homozygotes.
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Other studies reported high aggression being associated with either Met-allele carriers or no significant association.
“Other studies reported high aggression being associated with either Met-allele carriers [61], or no significant association [62].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [61]
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The Genetic Underpinning of Proactive and Reactive Aggression
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- Authors
- Albaugh, M. D., Harder, V. S., Althoff, R. R., Rettew, D. C., Ehli, E. A., Lengyel-Nelson, T., Davies, G. E., Ayer, L., Sulman, J., Stanger, C., & Hudziak, J. J.
- Affiliations
- University of Vermont (US)
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Hudziak, James J.
- ORCID
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 49
- Issue
- 8
- Pages
- 841-849
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC3141335
- OpenAlex
- W2015940570
- Cited by
- 60
- References
- 45
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 6 · 2012: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institute of Mental Health (K08MH082116, K20MH001265)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- COMT Val158Met polymorphism, catechol-O-methyltransferase, aggression, attention deficits, youth, genetic risk factors, direct aggression, Child Behavior Checklist, maternal ratings
- MeSH terms
- Adolescent, Aggression, Alleles, Attention Deficit Disorder with Hyperactivity, Catechol O-Methyltransferase, Child, Child Behavior Disorders, Female, Genotype, Humans, Male, Personality Assessment, Phenotype, Polymorphism, Genetic, Risk Factors, Vermont, Genetic Predisposition to Disease, Checklist
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