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Cooccurrence and bidirectional prediction of sleep disturbances and depression in older adults: Meta-analysis and systematic review
Abstract
The present study pooled the prevalence of sleep disturbances and depression in community-dwelling older adults (mean age≥60years) and quantified the strength of evidence of the relationship between these two problems. From 23 cross-sectional studies and five sets of baseline data, a high pooled prevalence of sleep disturbances (30.5%), depressive symptoms (18.1%) and coexisting disorders (10.6%) were found. In the 23 cohort studies, self-reported sleep disturbances increased the risk of the onset of depression (relative risk [RR]=1.92). Persistent sleep disturbances increased the risk of the development (RR=3.90), recurrence (RR=7.70), and worsening (RR=1.46) of depression in older adults. Little support was found for a predictive role for objective sleep characteristics in the development of depression. Older adults with depression had a higher risk of developing (RR=1.72) and worsening (RR=1.73) symptoms of sleep disturbances. This review emphasizes the importance of timely interventions in incipient sleep disturbances and depression among older adults, preventing the development of more serious comorbidities.
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“A meta-analysis pooling all 'sleep disturbances' (including insomnia, complaints of sleeping difficulties, and general poor sleep quality) found that they significantly increased the prospective risk for clinical depression or significant depressive symptoms (n=11, N=16,108, RR=1.92, 95% CI: 1.60-2.30, I 2 =10.2%), with even greater risk following 'persistent' sleep disturbances (n=4, N=3,602, RR=”
From A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders (2020) · cites this paper as [70]
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“with even greater risk following 'persistent' sleep disturbances (n=4, N=3,602, RR=3.90, 95% CI: 2.77-5.48, I 2 =27.1%) 70 .”
From A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders (2020) · cites this paper as [70]
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Metadata
- Authors
- Bao, Y.-P., Han, Y., Ma, J., Wang, R.-J., Shi, L., Wang, T.-Y., He, J., Yue, J.-L., Shi, J., Tang, X.-D., & Lu, L.
- Affiliations
- Peking University (CN)
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 75
- Pages
- 257-273
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2583719463
- Cited by
- 275
- References
- 123
- Citations by year
- 2026: 30 · 2025: 36 · 2024: 34 · 2023: 36 · 2022: 37 · 2021: 35 · 2020: 27 · 2019: 19 · 2018: 17 · 2017: 4
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Basic Research Program of China (2015CB856400, 2015CB553503)
- National Natural Science Foundation of China (81521063)
- Beijing Municipal Science and Technology Commission (Z151100003915121)
- Thirteenth Five-Year Program of the Chinese Ministry of Science and Technology (2016YFC0800907)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Keywords
- sleep disorders, depression, older adults, bidirectional prediction, comorbidities, prevalence, depression recurrence, community-dwelling older adults
- MeSH terms
- Cross-Sectional Studies, Depression, Depressive Disorder, Humans, Middle Aged, Sleep Wake Disorders, Comorbidity
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