Antioxidant, anti-inflammatory and neuroprotective actions of resveratrol after experimental nervous system insults. Special focus on the molecular mechanisms involved
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After different types of acute central nervous system insults, including stroke, subarachnoid haemorrhage and traumatic brain and spinal cord injuries, secondary damage plays a central role in the induction of cell death, neurodegeneration and functional deficits. Interestingly, secondary cell death presents an attractive target for clinical intervention because the temporal lag between injury and cell loss provides a potential window for effective treatment. While primary injuries are the direct result of the precipitating insult, secondary damage involves the activation of pathological cascades through which endogenous factors can exacerbate initial tissue damage. Secondary processes, usually interactive and overlapping, include oxidative stress, neuroinflammation and dysregulation of autophagy, ultimately leading to cell death. Resveratrol, a natural stilbene present at relatively high concentrations in grape skin and red wine, exerts a wide range of beneficial health effects. Within the central nervous system, in addition to its inherent free radical scavenging role, resveratrol increases endogenous cellular antioxidant defences thus modulating multiple synergistic pathways responsible for its antioxidant, anti-inflammatory and anti-apoptotic properties. During the last years, a growing body of in vitro and in vivo evidence has been built, indicating that resveratrol can induce a neuroprotective state and attenuate functional deficits when administered acutely after an experimental injury to the central nervous system. In this review, we summarize the most recent findings on the molecular pathways involved in the neuroprotective effects of this multi target polyphenol, and discuss its neuroprotective potential after brain or spinal cord injuries.
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ROS scavenging mechanisms interfere with the pathways responsible for antiapoptotic and anti-inflammatory properties.
“ROS scavenging mechanisms interfere with the pathways responsible for antiapoptotic and anti-inflammatory properties (Miguel et al. 2021).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Miguel et al. 2021
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- Authors
- Miguel, C. A., Noya-Riobó, M. V., Mazzone, G. L., Villar, M. J., & Coronel, M. F.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 150
- Pages
- 105188
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W3199891081
- Cited by
- 70
- References
- 107
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 16 · 2023: 14 · 2022: 13 · 2021: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- resveratrol, neuroprotection, secondary brain injury, stroke, subarachnoid hemorrhage, traumatic brain injury, spinal cord injury, oxidative stress, neuroinflammation, autophagy, apoptosis, antioxidant defense, polyphenols, molecular mechanisms
- MeSH terms
- Resveratrol, Neuroinflammatory Diseases, Animals, Anti-Inflammatory Agents, Antioxidants, Brain Injuries, Humans, Spinal Cord Injuries, Cell Death, Oxidative Stress, Neuroprotective Agents
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