Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect
Abstract
Diabetic neuropathic pain is one of the most commonly encountered neuropathic pain syndromes. However, the treatment of diabetic neuropathic pain is challenging because of partial effectiveness of currently available pain relievers. It is well known that diabetic animals are less sensitive to the analgesic effect of morphine, and opioids are found to be ineffective in the treatment of diabetic neuropathic pain. Cannabinoids are promising drugs and they share a similar pharmacological properties with opioids. It has been reported that cannabinoid analgesia remained intact and to be effective in some models of nerve injury. Thus, we investigated antinociceptive efficacy and the effects of cannabinoids on behavioral sign of diabetic neuropathic pain in diabetic mice by using WIN 55, 212-2, a cannabinoid receptor agonist. Diabetes was induced by streptozotocin (STZ) (200mg/kg) and animals were tested between 45 and 60 days after onset of diabetes. Antinociception was assessed using the radiant tail-flick test. Mechanical and thermal sensitivities were measured by Von Frey filaments and hot-plate test, respectively. Tactile allodynia, but not thermal hyperalgesia developed in diabetic mice. Systemic WIN 55, 212-2 (1, 5 and 10mg/kg) produced a dose-dependent antinociception both in diabetic and control mice. WIN 55, 212-2-induced antinociception were found to be similar in diabetic mice when compared to controls suggesting efficacy of cannabinoid antinociception was not diminished in diabetic mice. WIN 55, 212-2 also produced a dose-dependent antiallodynic effect in diabetic mice. This study suggests that cannabinoids have a potential beneficial effect on experimental diabetic neuropathic pain.
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THC and WIN55,212-2 produce antinociception in rodent STZ-induced peripheral neuropathy.
“Several studies have demonstrated that THC (Williams et al, 2008) and WIN55,212-2 (Bujalska, 2008;Doğrul et al, 2004;Ikeda et al, 2013;Jahanabadi et al, 2016;Mohammadi-Farani et al, 2010;Ulugol et al, 2004;Vera et al, 2012;Vincenzi et al, 2013) produce antinociception in rodent STZinduced peripheral neuropathy.”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Doğrul et al, 2004
Cites
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762 · see citing works
Quantitative assessment of tactile allodynia in the rat paw
Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M., & Yaksh, T. L. (1994) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(94)90144-9 · Cited by 7,740 · see citing works
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321 · see citing works
Efficient Analysis of Experimental Observations
Dixon, W. J. (1980) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.20.040180.002301 · Cited by 2,216 · see citing works
Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life
Galer, B. S., Gianas, A., & Jensen, M. P. (2000) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00112-6 · Cited by 601 · see citing works
Watson, P. C. N., Moulin, D. E., Watt-Watson, J. H., GORDON, A. S., & Eisenhoffer, J. (2003) · Pain · doi:10.1016/s0304-3959(03)00160-x · Cited by 508 · see citing works
Xiao, H., Huang, Q., Zhang, F., Bao, L., Lu, Y., Guo, C., Yang, L., Huang, W.-J., Fu, G., Xu, S., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122231899 · Cited by 501 · see citing works
VR1 protein expression increases in undamaged DRG neurons after partial nerve injury
Hudson, L. J., Bevan, S., Wotherspoon, G., Gentry, C., Fox, A., & Winter, J. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01591.x · Cited by 389 · see citing works
Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works
Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13308-5 · Cited by 307 · see citing works
Field, M. J., McCleary, S., Hughes, J. M., & Singh, L. (1999) · Pain · doi:10.1016/s0304-3959(98)00239-5 · Cited by 294 · see citing works
Hong, S., Morrow, T., Paulson, P. E., Isom, L. L., & Wiley, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404167200 · Cited by 268 · see citing works
Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats
Khan, G. M., Chen, S.-R., & Pan, H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00372-x · Cited by 234 · see citing works
Ossipov, M. H., Bian, D., Malan, P. T., Lai, J. Y., & Porreca, F. (1999) · Pain · doi:10.1016/s0304-3959(98)00187-0 · Cited by 218 · see citing works
Jadad, A. R., Carroll, D., Glynn, C. J., McQuay, H. J., & Moore, R. A. (1992) · The Lancet · doi:10.1016/0140-6736(92)91194-d · Cited by 200 · see citing works
Opioid responsiveness of cancer pain syndromes caused by neuropathic or nociceptive mechanisms
Cherny, N. I., Thaler, H. T., Friedlander-Klar, H., Lapin, J., Foley, K. M., Houde, R. W., & Portenoy, R. K. (1994) · Neurology · doi:10.1212/wnl.44.5.857 · Cited by 196 · see citing works
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat
Fox, A., Eastwood, C., Gentry, C., Manning, D. C., & Urbán, L. (1999) · Pain · doi:10.1016/s0304-3959(99)00024-x · Cited by 190 · see citing works
Pre- and postsynaptic distribution of cannabinoid and mu opioid receptors in rat spinal cord
Hohmann, A. G., Briley, E. M., & Herkenham, M. A. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01321-3 · Cited by 183 · see citing works
Bridges, D., Rice, A. S. C., Egertová, M., Elphick, M. R., Winter, J., & Michael, G. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00200-8 · Cited by 173 · see citing works
Synergistic interactions of endogenous opioids and cannabinoid systems
Welch, S. P., & Eads, M. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01908-3 · Cited by 169 · see citing works
Hypersensitivity of Spinothalamic Tract Neurons Associated With Diabetic Neuropathic Pain in Rats
Chen, S.-R., & Pan, H. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.6.2726 · Cited by 157 · see citing works
Simon, G. S., & Dewey, W. L. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32671-6 · Cited by 156 · see citing works
Ossipov, M. H., Lopez, Y., Nichols, M. L., Bian, D., & Porreca, F. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12022-v · Cited by 149 · see citing works
Spinal nerve ligation: what to blame for the pain and why
Gold, M. S. (2000) · Pain · doi:10.1016/s0304-3959(99)00309-7 · Cited by 128 · see citing works
Scott, D. A., Wright, C. E., & Angus, J. A. (2004) · Pain · doi:10.1016/j.pain.2004.01.020 · Cited by 128 · see citing works
Kamei, J., Ohhashi, Y., Aoki, T., Kawashima, N., & Kasuya, Y. (1992) · Brain Research · doi:10.1016/0006-8993(92)90655-s · Cited by 105 · see citing works
Two distinctive antinociceptive systems in rats with pathological pain
Mao, J., Price, D. D., Lü, J., Keniston, L., & Mayer, D. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00998-2 · Cited by 104 · see citing works
Hohmann, A. G., & Herkenham, M. A. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00534-5 · Cited by 102 · see citing works
Topical cannabinoid enhances topical morphine antinociception
Yeşilyurt, Ö., Dogrul, A., Gül, H., Seyrek, M., Kusmez, O., Özkan, Y., & Yıldız, O. (2003) · Pain · doi:10.1016/s0304-3959(03)00245-8 · Cited by 95 · see citing works
Self-citationCosta, B., Colleoni, M., Conti, S., Trovato, A. E., Bianchi, M., Sotgiu, M. L., & Giagnoni, G. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705587 · Cited by 89 · see citing works
Chen, S.-R., & Pan, H. (2003) · Anesthesiology · doi:10.1097/00000542-200312000-00026 · Cited by 87 · see citing works
Gül, H., Yıldız, O., Dogrul, A. B., Yeşilyurt, Ö., & Işimer, A. (2000) · Pain · doi:10.1016/s0304-3959(00)00343-2 · Cited by 82 · see citing works
Self-citationKapur, D. (2003) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.359 · Cited by 77 · see citing works
Ulugöl, A., Karadağ, Ç. H., Tamer, M., Firat, Z., Aslantaş, A., & Dökmeci, İ. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00491-3 · Cited by 76 · see citing works
Topical cannabinoid antinociception: synergy with spinal sites
Dogrul, A., Gül, H., Akar, A., Yıldız, O., Bilgin, F., & Güzeldemir, M. E. (2003) · Pain · doi:10.1016/s0304-3959(03)00068-x · Cited by 76 · see citing works
Self-citationGardell, L. R., Burgess, S. E., Dogrul, A. B., Ossipov, M. H., Malan, T. P., Lai, J., & Porreca, F. (2002) · Pain · doi:10.1016/s0304-3959(01)00475-4 · Cited by 45 · see citing works
Dogrul, A. B., Gardell, L. R., Ma, S.-W., Ossipov, M. H., Porreca, F., & Lai, J. Y. (2002) · Pain · doi:10.1016/s0304-3959(02)00302-0 · Cited by 34 · see citing works
Treatment of Chronic Intractable Neuropathetic Pain with Dronabinol: Case Report of Two Adolescents
Rudich, Z., Stinson, J., Jeavons, M., & Brown, S. C. (2003) · Pain Research and Management · doi:10.1155/2003/675976 · Cited by 30 · see citing works
Ohsawa, M., Mizoguchi, H., Narita, M., Narita, M., Kamei, J., Nagase, H., & Tseng, L. F. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00408-8 · Cited by 27 · see citing works
Ohsawa, M., Nagase, H., & Kamei, J. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37653-0 · Cited by 24 · see citing works
New treatments for diabetic neuropathy: Symptomatic treatments
Krishnan, S. T. M., & Rayman, G. A. (2003) · Current Diabetes Reports · doi:10.1007/s11892-003-0008-y · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cannabinoids as Novel Anti-Inflammatory Drugs
Nagarkatti, P., Pandey, R., Rieder, S. A., Hegde, V. L., & Nagarkatti, M. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.93 · Cited by 555 · see citing works
“Mice injected with a cannabis receptor agonist experienced a reduction in diabeticrelated tactile allodynia compared with nontreated controls [130].”
Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside
Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
Donvito, G., Nass, S. R., Wilkerson, J. L., Curry, Z. A., Schurman, L. D., Kinsey, S. G., & Lichtman, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.204 · Cited by 301 · see citing works
Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy
Wallace, M. S., Marcotte, T. D., Umlauf, A., Gouaux, B., & Atkinson, J. H. (2015) · The Journal of Pain · doi:10.1016/j.jpain.2015.03.008 · Cited by 276 · see citing works
Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
Petrosino, S., Palazzo, E., de Novellis, V., Bisogno, T., Rossi, F., Maione, S., & Di Marzo, V. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.08.011 · Cited by 227 · see citing works
The analgesic potential of cannabinoids.
Elikottil, M., Gupta, M., & Gupta, P. (2018) · Journal of Opioid Management · doi:10.5055/jom.2009.0034 · Cited by 141 · see citing works
Walczak, J., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20821 · Cited by 62 · see citing works
Bujalska, M. (2008) · Pharmacology · doi:10.1159/000156485 · Cited by 20 · see citing works
URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats
Hasanein, P., Parviz, M., Keshavarz, M., & Roohbakhsh, A. (2009) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y09-026 · Cited by 14 · see citing works
- Authors
- Doğrul, A., Gül, H., Yıldız, O., Bilgin, F., & Güzeldemir, M. E.
- Affiliations
- Gülhane Askerî Tıp Akademisi (TR)
- Corresponding author
- Doğrul, Ahmet
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 368
- Issue
- 1
- Pages
- 82-86
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1980161112
- Cited by
- 61
- References
- 41
- Citations by year
- 2023: 2 · 2021: 2 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 5
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- cannabinoids, diabetic neuropathic pain, mechanical allodynia, antinociception, WIN 55,212-2, cannabinoid receptor agonists, streptozotocin-induced diabetes, thermal hyperalgesia, mechanical sensitivity
- MeSH terms
- Animals, Behavior, Animal, Cannabinoids, Diabetes Mellitus, Experimental, Dose-Response Relationship, Drug, Female, Hot Temperature, Mice, Inbred BALB C, Morpholines, Naphthalenes, Pain, Pain Measurement, Physical Stimulation, Reaction Time, Benzoxazines, Mice, Cannabinoid Receptor Agonists
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