Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376 · see citing works

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

Hargreaves, K., Dubner, R. A., Brown, F. J., Flores, C., & Joris, J. L. (1988) · Pain · doi:10.1016/0304-3959(88)90026-7 · Cited by 5,155 · see citing works

Animal Models of Nociception

Rácz, I., & Zimmer, A. (2006) · doi:10.1002/9783527611942.ch9 · Cited by 1,659 · see citing works

Animal models of nociception

Le Bars, D., Gozariu, M., & Cadden, S. W. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01514-x · Cited by 1,459 · cited 1× · see citing works

Morphine, Gabapentin, or Their Combination for Neuropathic Pain

Gilron, I., Bailey, J. M., Tu, D., Holden, R. R., Weaver, D. F., & Houlden, R. L. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042580 · Cited by 1,080 · see citing works

Oral Opioid Therapy for Chronic Peripheral and Central Neuropathic Pain

Rowbotham, M. C., Twilling, L., Davies, P. S., Reisner, L. A., Taylor, K., & Mohr, D. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021420 · Cited by 529 · see citing works

CB ₂ cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

Ibrahim, M. M., Porreca, F., Lai, J., Albrecht, P. J., Rice, F. L., Khodorova, A., Davar, G., Makriyannis, A., Vanderah, T. W., Mata, H. P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409888102 · Cited by 521 · see citing works

Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve

Tal, M., & Bennett, G. J. (1994) · Pain · doi:10.1016/0304-3959(94)90013-2 · Cited by 436 · see citing works

Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models

Zhang, J., Hoffert, C., Vu, H. K., Groblewski, T., Ahmad, S., & O'Donnell, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02704.x · Cited by 419 · see citing works

Receptive Properties of Mouse Sensory Neurons Innervating Hairy Skin

Koltzenburg, M., Stucky, C. L., & Lewin, G. R. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.78.4.1841 · Cited by 384 · see citing works

The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain

Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works

The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain

Hunter, J. C., Gogas, K. R., Hedley, L. R., Jacobson, L. O., Kassotakis, L., Thompson, J., & Fontana, D. J. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)00070-8 · Cited by 310 · see citing works

Pronociceptive actions of dynorphin maintain chronic neuropathic pain

Wang, Z., Gardell, L. R., Ossipov, M. H., Vanderah, T. W., Brennan, M. B., Hochgeschwender, U., Hruby, V. J., Malan, T. P., Lai, J., & Porreca, F. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01779.2001 · Cited by 301 · see citing works

Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing

Wright, K. L., ROONEY, N., Feeney, M., Tate, J. J. T., Robertson, D. A., Welham, M. J., & Ward, S. G. (2005) · Gastroenterology · doi:10.1016/j.gastro.2005.05.026 · Cited by 300 · see citing works

Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy

Valenzano, K. J., Tafesse, L., Lee, G., Harrison, J. E., Boulet, J. M., Gottshall, S. L., Mark, L., Pearson, M. S., Miller, W., Shan, S., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.12.008 · Cited by 288 · see citing works

Sensory receptors in mammalian skin in an in vitro preparation

Reeh, P. W. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90180-1 · Cited by 281 · see citing works

Differential Expression of Cannabinoid Receptors in the Human Colon: Cannabinoids Promote Epithelial Wound Healing

Wright, K. L., Rooney, N., Feeney, M., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.026 · Cited by 262 · see citing works

Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons

Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., & Winter, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.009 · Cited by 251 · see citing works

Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain

Peters, C. M., Ghilardi, J. R., Keyser, C. P., Kubota, K., Lindsay, T. H., Luger, N. M., Mach, D. B., Schwei, M. J., Sevcik, M. A., & Mantyh, P. W. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.028 · Cited by 210 · see citing works

Pharmacological characterisation of the spared nerve injury model of neuropathic pain

Erichsen, H. K., & Blackburn-Munro, G. (2002) · Pain · doi:10.1016/s0304-3959(02)00039-8 · Cited by 206 · see citing works

Gabapentin in the treatment of neuropathic pain

Bennett, M., & Simpson, K. H. (2004) · Palliative Medicine · doi:10.1191/0269216304pm845ra · Cited by 203 · see citing works

Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats

Lim, G., Sung, B., Ji, R.-R., & Mao, J. (2003) · Pain · doi:10.1016/s0304-3959(03)00242-2 · Cited by 195 · see citing works

Pharmacological characterization of the chronic constriction injury model of neuropathic pain

Vry, J. D., Kuhl, E., Franken‐Kunkel, P., & Eckel, G. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.03.051 · Cited by 184 · see citing works

The Tetrodotoxin‐Resistant Na+ Channel Nav1.8 is Essential for the Expression of Spontaneous Activity in Damaged Sensory Axons of Mice

Roza, C., Laird, J. M. A., Souslova, V., Wood, J. N., & Cerveró, F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.046110 · Cited by 180 · see citing works

Reorganization of the spinal dorsal horn in models of chronic pain: correlation with behaviour

Goff, J. R., Burkey, A. R., Goff, D. J., & Jasmin, L. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00298-4 · Cited by 157 · see citing works

Paclitaxel-induced neuropathic hypersensitivity in mice: Responses in 10 inbred mouse strains

Smith, S. B., Crager, S. E., & Mogil, J. S. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.01.002 · Cited by 147 · see citing works

Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour

Idänpään-Heikkilä, J. J., & Guilbaud, G. (1999) · Pain · doi:10.1016/s0304-3959(98)00172-9 · Cited by 145 · see citing works

Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects

Esser, M. J., & Sawynok, J. (1999) · Pain · doi:10.1016/s0304-3959(98)00261-9 · Cited by 144 · see citing works

μ Opioid receptors and analgesia at the site of a peripheral nerve injury

Truong, W., Cheng, C., Xu, Q., Li, X., & Zochodne, D. W. (2003) · Annals of Neurology · doi:10.1002/ana.10465 · Cited by 142 · see citing works

Role of descending noradrenergic system and spinal α2‐adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse

Tanabe, M., Takasu, K., Kasuya, N., Shimizu, S., Honda, M., & Ono, H. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706109 · Cited by 139 · see citing works

Focal lysolecithin-induced demyelination of peripheral afferents results in neuropathic pain behavior that is attenuated by cannabinoids

Wallace, V. C. J., Cottrell, D. F., Brophy, P. J., & Fleetwood-Walker, S. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03221.2003 · Cited by 134 · see citing works

Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain

Walczak, J.-S., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.02.010 · Cited by 133 · see citing works

Loss of Peripheral Morphine Analgesia Contributes to the Reduced Effectiveness of Systemic Morphine in Neuropathic Pain

Rashid, H., Inoue, M., Toda, K., & Ueda, H. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060582 · Cited by 122 · see citing works

Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats

Chapman, V., Suzuki, R., Chamarette, H. L. C., Rygh, L. J., & Dickenson, A. H. (1998) · Pain · doi:10.1016/s0304-3959(98)00004-9 · Cited by 118 · see citing works

Proinflammatory Chemokines, Such as C-C Chemokine Ligand 3, Desensitize μ-Opioid Receptors on Dorsal Root Ganglia Neurons

Zhang, N., Rogers, T. J., Caterina, M. J., & Oppenheim, J. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.594 · Cited by 117 · see citing works

Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620

Castro, C. A., Hogan, J. B., Benson, K. A., Shehata, C. W., & Landauer, M. R. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)00331-9 · Cited by 114 · see citing works

Wallerian degeneration: history and clinical significance

Koeppen, A. H. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.03.008 · Cited by 110 · see citing works

STANDARD INTRAVESICAL THERAPIES FOR INTERSTITIAL CYSTITIS

Sant, G. R., & LaRock, D. (1994) · Urologic Clinics of North America · doi:10.1016/s0094-0143(21)00594-2 · Cited by 93 · see citing works

Antinociceptive Effect of Morphine, but not μ Opioid Receptor Number, Is Attenuated in the Spinal Cord of Diabetic Rats

Chen, S.-R., & Pan, H. (2003) · Anesthesiology · doi:10.1097/00000542-200312000-00026 · Cited by 87 · see citing works

Local peripheral effects of μ-opioid receptor agonists in neuropathic pain in rats

Obara, I., Przewłocki, R., & Przewłocka, B. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.056 · Cited by 86 · see citing works

Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve

George, A., Buehl, A., & Sommer, C. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.11.002 · Cited by 85 · see citing works

A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy

Sommer, C., Schmidt, C., George, A., & Toyka, K. V. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00813-6 · Cited by 77 · see citing works

Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions

Esser, M. J., Chase, T. D., Allen, G. V., & Sawynok, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01276-6 · Cited by 70 · see citing works

Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain

Hofmann, H. A., De Vry, J., Siegling, A., Spreyer, P., & Denzer, D. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01753-9 · Cited by 70 · see citing works

Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study

Cavaletti, G., Oggioni, N., Sala, F., Pezzoni, G., Cavalletti, E., Marmiroli, P., Petruccioli, M. G., Frattola, L., & Tredici, G. (2000) · Toxicology Letters · doi:10.1016/s0378-4274(00)00269-1 · Cited by 64 · see citing works

Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect

Doğrul, A., Gül, H., Yıldız, O., Bilgin, F., & Güzeldemir, M. E. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.060 · Cited by 61 · see citing works

Nerve Injury Induces a Tonic Bilateral μ-Opioid Receptor–mediated Inhibitory Effect on Mechanical Allodynia in Mice

Mansikka, H. T., Zhao, C., Sheth, R. N., Sora, I., Uhl, G. R., & Raja, S. N. (2004) · Anesthesiology · doi:10.1097/00000542-200404000-00022 · Cited by 60 · see citing works

Pharmacological and Immunohistochemical Characterization of a Mouse Model of Acute Herpetic Pain

Takasaki, I., Andoh, T., Nitta, M., Takahata, H., Nemoto, H., Shiraki, K., Nojima, H., & Kuraishi, Y. (2000) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.83.319 · Cited by 57 · see citing works

Change of dorsal horn neurochemistry in a mouse model of neuropathic cancer pain

Shimoyama, M., Tatsuoka, H., Ohtori, S., Tanaka, K., & Shimoyama, N. (2005) · Pain · doi:10.1016/j.pain.2004.12.018 · Cited by 56 · see citing works

Pharmacological Studies of Nociceptive Systems Using the C-Fos Immunohistochemical Technique: An Indicator of Noxiously Activated Spinal Neurones

Chapman, V., & Besson, J. (1997) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-60777-6_10 · Cited by 55 · see citing works

Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice

Gustafsson, H., Flood, K., Berge, O., Brodin, E., Olgart, L. M., & Stiller, C. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00097-9 · Cited by 38 · see citing works

Protective Effect of Lafutidine, a Novel H2-Receptor Antagonist, on Reflux Esophagitis in Rats Through Capsaicin-Sensitive Afferent Neurons

Nagahama, K., Yamato, M., Kato, S., & Takeuchi, K. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.93.55 · Cited by 34 · see citing works

Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat

Hama, A. T., & Borsook, D. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.03.009 · Cited by 32 · see citing works

Heme oxygenase type 2 participates in the development of chronic inflammatory and neuropathic pain

Li, X., & Clark, J. D. (2003) · Journal of Pain · doi:10.1054/jpai.2003.18 · Cited by 31 · see citing works

Molecular mechanism of changes in the morphine-induced pharmacological actions under chronic pain-like state: Suppression of dopaminergic transmission in the brain

Narita, M., Suzuki, M., Imai, S., Narita, M., Ozaki, S., Kishimoto, Y., Oe, K., Yajima, Y., Yamazaki, M., & Suzuki, T. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.01.006 · Cited by 28 · see citing works

Effects of a μ-opioid receptor agonist on G-protein activation in streptozotocin-induced diabetic mice

Ohsawa, M., Mizoguchi, H., Narita, M., Narita, M., Kamei, J., Nagase, H., & Tseng, L. F. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00408-8 · Cited by 27 · see citing works

Inhibition of neuropathic pain by a potent disintegrin—triflavin

Fu, W., Chang, T.-K., Sun, W., Ling, Q., Peng, H., Liou, H., Lu, D., & Huang, T. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.06.035 · Cited by 19 · see citing works

Spinal neurophysiologic correlates of the analgesic actions of intravesical dimethyl sulfoxide and capsaicin in the rat

Castromán, P., & Ness, T. J. (2002) · Journal of Pain · doi:10.1054/jpai.2002.126789 · Cited by 10 · see citing works

The influence of in vivo administration of dimethyl sulfoxide on the in vitro metabolism of some monocyclic aromatic chemicals by hepatic microsomal preparations

Stock, B. H., & Fouts, J. R. (1971) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(71)90234-1 · Cited by 8 · see citing works

The diverse CB 1 and CB 2 receptor pharmacology of three plant cannabinoids: Δ 9 ‐tetrahydrocannabinol, cannabidiol and Δ 9 ‐tetrahydrocannabivarin

Pertwee, R. G. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707442 · Cited by 1,953 · see citing works

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

Pertwee, R. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00048.x · Cited by 436 · see citing works

Cannabinoid CB ₂ receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain

Guindon, J., & Hohmann, A. G. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707531 · Cited by 423 · see citing works

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

Pertwee, R. G. (2008) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00108.x · Cited by 314 · see citing works

Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside

Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works

Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats

Petrosino, S., Palazzo, E., de Novellis, V., Bisogno, T., Rossi, F., Maione, S., & Di Marzo, V. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.08.011 · Cited by 227 · see citing works

Modulation of pain transmission by G-protein-coupled receptors

Pan, H., Wu, Z.-Z., Zhou, H.-Y., Chen, S.-R., Zhang, H., & Li, D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.09.003 · Cited by 197 · see citing works

Modulation of Peripheral Sensory Neurons by the Immune System: Implications for Pain Therapy

Stein, C., & Machelska, H. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003145 · Cited by 182 · see citing works

Central and peripheral sites of action for CB ₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

Hsieh, G. C., Pai, M., Chandran, P., Hooker, B. A., Zhu, C. Z., Salyers, A. K., Wensink, E. J., Zhan, C., Carroll, W. A., Dart, M. J., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01046.x · Cited by 139 · see citing works

The role of endocannabinoids in pain modulation

Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. E. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12008 · Cited by 106 · see citing works

The antinociceptive effects of intraplantar injections of 2‐arachidonoyl glycerol are mediated by cannabinoid CB2receptors

Guindon, J., Desroches, J., & Beaulieu, P. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706990 · Cited by 101 · see citing works

Validating Antibodies to the Cannabinoid CB2 Receptor

Marchalant, Y., Brownjohn, P. W., Bonnet, A., Kleffmann, T., & Ashton, J. C. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414530995 · Cited by 91 · see citing works

Endogenous opiates and behavior: 2006

Bodnar, R. J. (2007) · Peptides · doi:10.1016/j.peptides.2007.09.002 · Cited by 91 · see citing works

2,3‐Dihydro‐1‐Benzofuran Derivatives as a Series of Potent Selective Cannabinoid Receptor 2 Agonists: Design, Synthesis, and Binding Mode Prediction through Ligand‐Steered Modeling

Diaz, P., Phatak, S. S., Xu, J. J., Fronczek, F. R., Astruc‐Diaz, F., Thompson, C. M., Cavasotto, C. N., & Naguib, M. (2009) · ChemMedChem · doi:10.1002/cmdc.200900226 · Cited by 88 · see citing works

Evidence for a novel functional role of cannabinoid CB₂ receptors in the thalamus of neuropathic rats

Jhaveri, M. D., Elmes, S. J. R., Richardson, D., Barrett, D. A., Kendall, D. A., Mason, R., & Chapman, V. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06162.x · Cited by 88 · see citing works

Cannabinoid CB2 Receptor-Mediated Anti-nociception in Models of Acute and Chronic Pain

Jhaveri, M. D., Sagar, D. R., Elmes, S. J. R., Kendall, D. A., & Chapman, V. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8007-7 · Cited by 89 · see citing works

6-Methoxy-N-alkyl Isatin Acylhydrazone Derivatives as a Novel Series of Potent Selective Cannabinoid Receptor 2 Inverse Agonists: Design, Synthesis, and Binding Mode Prediction

Diaz, P., Phatak, S. S., Xu, J. J., Astruc‐Diaz, F., Cavasotto, C. N., & Naguib, M. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm801353p · Cited by 71 · see citing works

Crotalphine induces potent antinociception in neuropathic pain by acting at peripheral opioid receptors

Gutierrez, V. P., Konno, K., Chacur, M., Sampaio, S. C., Picolo, G., Brigatte, P., Zambelli, V. O., & Cury, Y. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.07.053 · Cited by 72 · see citing works

Design and Synthesis of a Novel Series ofN-Alkyl Isatin Acylhydrazone Derivatives that Act as Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic Pain

Diaz, P., Xu, J. J., Astruc‐Diaz, F., Pan, H.-M., Brown, D. L., & Naguib, M. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8002203 · Cited by 69 · see citing works

Evaluation of the specificity of antibodies raised against cannabinoid receptor type 2 in the mouse retina

Cécyre, B., Thomas, S., Ptito, M., Casanova, C., & Bouchard, J. (2013) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-013-0930-8 · Cited by 68 · see citing works

Prophylactic Cannabinoid Administration Blocks the Development of Paclitaxel-Induced Neuropathic Nociception during Analgesic Treatment and following Cessation of Drug Delivery

Rahn, E. J., Deng, L., Thakur, G. A., Vemuri, K. V., Zvonok, A. M., Lai, Y. Y., Makriyannis, A., & Hohmann, A. G. (2014) · Molecular Pain · doi:10.1186/1744-8069-10-27 · Cited by 65 · see citing works

Modulation of the anti‐nociceptive effects of 2‐arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model

Desroches, J., Guindon, J., Lambert, C., & Beaulieu, P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.322 · Cited by 63 · see citing works

Targeting the cannabinoid system for pain relief?

Chiou, L., Hu, S. S., & Ho, Y. (2013) · Acta anaesthesiologica Taiwanica · doi:10.1016/j.aat.2013.10.004 · Cited by 57 · see citing works

Dual Peripheral Actions of Immune Cells in Neuropathic Pain

Machelska, H. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-010-0106-x · Cited by 52 · see citing works

Endocannabinoids decrease neuropathic pain-related behavior in mice through the activation of one or both peripheral CB1 and CB2 receptors

Desroches, J., Charron, S., Bouchard, J., & Beaulieu, P. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.006 · Cited by 51 · see citing works

Targeting Peripherally Restricted Cannabinoid Receptor 1, Cannabinoid Receptor 2, and Endocannabinoid-Degrading Enzymes for the Treatment of Neuropathic Pain Including Neuropathic Orofacial Pain

Hossain, M. Z., Ando, H., Unno, S., & Kitagawa, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041423 · Cited by 52 · see citing works

Involvement of cannabinoid receptors in peripheral and spinal morphine analgesia

Desroches, J., Bouchard, J., Gendron, L., & Beaulieu, P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.030 · Cited by 49 · see citing works

Pharmacological correlation between the formalin test and the neuropathic pain behavior in different species with chronic constriction injury

Vissers, K. C. P., Geenen, F., Biermans, R., & Meert, T. F. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.06.011 · Cited by 49 · see citing works

Cannabinoids in Chronic Pain: Therapeutic Potential Through Microglia Modulation

van den Hoogen, N. J., Harding, E. K., Davidson, C. E. D., & Trang, T. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.816747 · Cited by 45 · see citing works

Combined carbamazepine and pregabalin therapy in a rat model of neuropathic pain

Hahm, T. S., Ahn, H. J., Ryu, S., Gwak, M. S., Choi, S. J., Kim, J. K., & Yu, J. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes306 · Cited by 36 · see citing works

Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice

Hoot, M. R., Sim‐Selley, L. J., Poklis, J. L., Abdullah, R. A., Scoggins, K. L., Selley, D. E., & Dewey, W. L. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.105 · Cited by 32 · see citing works

The Anticonvulsant Enaminone E139 Attenuates Paclitaxel‐Induced Neuropathic Pain in Rodents

Thangamani, D., Edafiogho, I. O., & Masocha, W. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/240508 · Cited by 30 · see citing works

μ-Opioid Receptor Antibody Reveals Tissue-Dependent Specific Staining and Increased Neuronal μ-Receptor Immunoreactivity at the Injured Nerve Trunk in Mice

Schmidt, Y., Gavériaux‐Ruff, C., & Machelska, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079099 · Cited by 28 · see citing works

Immune cell-mediated opioid analgesia

Machelska, H., & Celik, M. Ö. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.08.005 · Cited by 23 · see citing works

Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice

Jafari, M. R., Golmohammadi, S., Ghiasvand, F., Zarrindast, M., & DJAHANGUIRI, B. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f00c10 · Cited by 22 · see citing works

Novel targets for Spinal Cord Injury related neuropathic pain

Ahmed, M. M., King, K. C., Pearce, S. M., Ramsey, M. A., Miranpuri, G. S., & Resnick, D. K. (2011) · Annals of Neurosciences · doi:10.5214/ans.0972.7531.1118413 · Cited by 22 · see citing works

Peripheral and central sites of action for the non‐selective cannabinoid agonist WIN 55,212‐2 in a rat model of post‐operative pain

Zhu, C. Z., Mikusa, J., Fan, Y., Hollingsworth, P. R., Pai, M., Chandran, P., Daza, A. V., Yao, B., Dart, M. J., Meyer, M., et al. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00184.x · Cited by 21 · see citing works

Constitutive Activity at the Cannabinoid CB1 Receptor and Behavioral Responses

Hanlon, K. E., & Vanderah, T. W. (2010) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-381298-8.00001-0 · Cited by 19 · see citing works

Dose-Dependent Effect of Hyperbaric Oxygen Treatment on Burn-Induced Neuropathic Pain in Rats

Wu, Z., Wu, S., Lee, S., Lin, C.-H., Chang, C., Lo, J.-J., Chai, C., Wu, C., & Huang, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081951 · Cited by 18 · see citing works

Cutaneous Nociceptors Lack Sensitisation, but Reveal μ-Opioid Receptor-Mediated Reduction in Excitability to Mechanical Stimulation in Neuropathy

Schmidt, Y., Łabuz, D., Heppenstall, P. A., & Machelska, H. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-81 · Cited by 16 · see citing works

Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats

Gündüz, Ö., Oltulu, Ç., Guven, R., Buldum, D., & Ulugöl, A. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0761-7 · Cited by 13 · see citing works

Increased spinal c-Fos expression with noxious and non-noxious peripheral stimulation after severe spinal contusion

Berrocal, Y. A., Pearse, D. D., Andrade, C., Hechtman, J. F., Puentes, R., & Eaton, M. J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.11.030 · Cited by 13 · see citing works

Peripheral Nerve Ligation Elicits Widespread Alterations in Cortical Sensory Evoked and Spontaneous Activity

Ashby, D. M., LeDue, J. M., Murphy, T. H., & McGirr, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-51811-8 · Cited by 12 · see citing works

Therapeutic Targeting of Peripheral Cannabinoid Receptors in Inflammatory and Neuropathic Pain States

Spigelman, I. (2009) · Frontiers in neuroscience · doi:10.1201/9781439812105-c5 · Cited by 12 · see citing works

Treatments for neuropathic pain differentially affect delayed matching accuracy by macaques: Effects of amitriptyline and gabapentin

Buccafusco, J. J., Terry, A. V., Vazdarjanova, A. I., Snutch, T. P., & Arnerić, S. P. (2010) · Pain · doi:10.1016/j.pain.2009.12.003 · Cited by 10 · see citing works

Topical loperamide for the treatment of localized neuropathic pain: a case report and literature review

Kopsky, D. J., Bhaskar, A. K., Zonneveldt, H., & Hesselink, J. M. K. (2019) · Journal of Pain Research · doi:10.2147/jpr.s196927 · Cited by 10 · see citing works

Cannabinoids and Pain Control in the Periphery

McDougall, J. J. (2009) · Wiley eBooks · doi:10.1002/9780470522226.ch13 · Cited by 9 · see citing works

Skin–Nerve Preparation to Assay the Function of Opioid Receptors in Peripheral Endings of Sensory Neurons

Moshourab, R. A., Schmidt, Y., & Machelska, H. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1708-2_17 · Cited by 4 · see citing works

Pain: Mechanisms and Measurement

Guindon, J., & Hohmann, A. G. (2009) · doi:10.1002/9780470478509.neubb002033 · Cited by 4 · see citing works

Management of chronic pain

Abelson, K., & Grøndahl, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-822215-7.00015-9 · Cited by 4 · see citing works

Cannabinoid Receptor Mediated Analgesia: Novel Targets for Chronic Pain States

Chapman, V., Kendall, D. A., & Sagar, D. R. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0226-9_15 · Cited by 1 · see citing works

Antiepileptic Drugs in the Treatment ofNeuropathic Pain

Guay, D. R. P. (2008) · Medical psychiatry · doi:10.3109/9780849382666.003 · Cited by 1 · see citing works

Management of Chronic Pain

DeMarco, G. J. (2008) · Elsevier eBooks · doi:10.1016/b978-012373898-1.50030-9

Peripheral opioid receptors and inhibition of sensory neuron excitability following nerve injury

Schmidt, Y. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17807

Changes in endocannabinoid signaling contribute to the anti-hyperalgesic effect of URB597 in a murine model of persistent inflammation.

Lindberg, A. E. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)

Investigating the Glial Contribution to Persistent Neuropathic Pain

Whitley, S. T. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/szj3-5t06

Current World Literature

(2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3282efeb3b

Etudes de trois métalloprotéases matricielles, MT1-MMP, MT5-MMP et MMP-12 dans l'amyloïdogenèse et les atteintes inflammatoires et vasculaires associées à la maladie d'Alzheimer

Bonnet, A. (2017) · doi:10.70675/7fa1337ez8c86z4faezb643z1ee618bb3cfa

Delta opioid receptor expression in various models of chronic clinical conditions

Ceredig, R. A. (2016) · theses.fr (ABES) · doi:10.70675/e750f280zf542z480dz8e6czab49ecd74230

Sex-specific differences in nociceptive behaviour and the amygdala endocannabinoid system in the rat monoiodoacetate-induced knee osteoarthritis model

Ferdousi, M. I., Infantino, R., Redmond, M. C., Krishnan, S. D., Adjei, C. K., McDermott, B., Liddy, A., Quinlan, L. R., O’Halloran, M., & Finn, D. P. (2026) · Neurobiology of Pain · doi:10.1016/j.ynpai.2026.100227

BindingDB Entry 50038718: 6-Methoxy-N-alkyl isatin acylhydrazone derivatives as a novel series of potent selective cannabinoid receptor 2 inverse agonists: design, synthesis, and binding mode prediction.

BindingDB (2012) · UC San Diego · doi:10.7270/q20g3m2x

BindingDB Entry 50038649: Design and synthesis of a novel series of N-alkyl isatin acylhydrazone derivatives that act as selective cannabinoid receptor 2 agonists for the treatment of neuropathic pain.

BindingDB (2012) · UC San Diego · doi:10.7270/q2x067zq

Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats

Gündüz, Ö., Oltulu, Ç., Guven, R., Buldum, D., & Ulugöl, A. (2011) · Neurological Sciences · doi:10.1007/s10072-011-0761-7 · Cited by 13 · see citing works

Mechanical Allodynia Assessment in a Murine Neuropathic Pain Model

Notartomaso, S., Scarselli, P., Pietro, P. D., Battaglia, G., Llebaria, A., Ciruela, F., & Nicoletti, F. (2018) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2671 · Cited by 13 · see citing works

Characterization of the sensory, affective, cognitive, biochemical, and neuronal alterations in a modified chronic constriction injury model of neuropathic pain in mice

de Medeiros, P. S., de Freitas, R. L., Boccella, S., Iannotta, M., Belardo, C., Mazzitelli, M., Romano, R., Gregorio, D. D., Coimbra, N. C., Palazzo, E., et al. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24501 · Cited by 51 · see citing works

Characterization of a novel neuropathic pain model in mice

Hulse, R. P., Wynick, D., & Donaldson, L. F. (2008) · Neuroreport · doi:10.1097/wnr.0b013e328300ee0a · Cited by 21 · see citing works

Sciatic nerve cuffing in mice: A model of sustained neuropathic pain

Benbouzid, M., Pallage, V., Rajalu, M., Waltisperger, E., Doridot, S., Poisbeau, P., Freund‐Mercier, M. J., & Barrot, M. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.10.002 · Cited by 164 · see citing works