Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy
Open accessAbstract
Unlabelled A randomized, double-blinded, placebo controlled crossover study was conducted in 16 patients with painful diabetic peripheral neuropathy to assess the short-term efficacy and tolerability of inhaled cannabis. In a crossover design, each participant was exposed to 4 single dosing sessions of placebo or to low (1% tetrahydrocannabinol [THC]), medium (4% THC), or high (7% THC) doses of cannabis. Baseline spontaneous pain, evoked pain, and cognitive testing were performed. Subjects were then administered aerosolized cannabis or placebo and the pain intensity and subjective "highness" score was measured at 5, 15, 30, 45, and 60 minutes and then every 30 minutes for an additional 3 hours. Cognitive testing was performed at 5 and 30 minutes and then every 30 minutes for an additional 3 hours. The primary analysis compared differences in spontaneous pain over time between doses using linear mixed effects models. There was a significant difference in spontaneous pain scores between doses (P < .001). Specific significant comparisons were placebo versus low, medium, and high doses (P = .031, .04, and <.001, respectively) and high versus low and medium doses (both P < .001). There was a significant effect of the high dose on foam brush and von Frey evoked pain (both P < .001). There was a significant negative effect (impaired performance) of the high dose on 2 of the 3 neuropsychological tests (Paced Auditory Serial Addition Test, Trail Making Test Part B.Perspective This small, short-term, placebo-controlled trial of inhaled cannabis demonstrated a dose-dependent reduction in diabetic peripheral neuropathy pain in patients with treatment-refractory pain. This adds preliminary evidence to support further research on the efficacy of the cannabinoids in neuropathic pain.
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In patients with painful diabetic peripheral neuropathy, different formulations of inhaled cannabis showed a significant dose-dependent effect on spontaneous pain score and allodynia.
“A randomized, doubleblinded, placebo controlled study conducted in patients with painful diabetic peripheral neuropathy using different formulation of inhaled cannabis showed a significant dosedependent effect on spontaneous pain score and allodynia (Wallace et al, 2015).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Wallace et al, 2015
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- Authors
- Wallace, M. S., Marcotte, T. D., Umlauf, A., Gouaux, B., & Atkinson, J. H.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Wallace, Mark S.
- Venue
- The Journal of Pain
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 16
- Issue
- 7
- Pages
- 616-627
- ISSN
- 1526-5900 (ISSN-L)
- PMC
- PMC5152762
- OpenAlex
- W2081629704
- Cited by
- 276
- References
- 55
- Citations by year
- 2026: 14 · 2025: 42 · 2024: 31 · 2023: 21 · 2022: 35 · 2021: 23 · 2020: 19 · 2019: 22 · 2018: 36 · 2017: 19 · 2016: 11 · 2015: 3
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P30MH062512)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- inhaled cannabis, tetrahydrocannabinol, diabetic peripheral neuropathy, neuropathic pain, refractory pain, dose-dependent analgesia, spontaneous pain, evoked pain, cognitive impairment, tolerability, cannabinoids
- MeSH terms
- Administration, Inhalation, Aged, Analysis of Variance, Cognition, Depression, Diabetic Neuropathies, Double-Blind Method, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Pain Measurement, Dronabinol, Time Factors, Treatment Outcome, Cross-Over Studies, Analgesics, Non-Narcotic
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