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Cited by 21Child Abuse and TraumaAdvanced Neuroimaging Techniques and ApplicationsStress Responses and Cortisol

White-matter density abnormalities in depressive patients with and without childhood neglect: a voxel-based morphometry (VBM) analysis

Peng, Hongjun, Ning, Yuping, Zhang, Yan, Yang, Haichen, Zhang, Li, He, Zhong, Li, Zexuan, Wang, Lifeng +4 more·2013·Neuroscience Letters
DOI 10.1016/j.neulet.2013.06.048
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Abstract

Childhood maltreatment (abuse or neglect) can result in changes to the brain structures and functions that underlie adult depression. Few studies have explored the impact of childhood maltreatment on white-matter microstructure, especially for childhood neglect. Nineteen depressive patients who experienced childhood neglect, 21 depressive patients who did not experience childhood neglect, and 20 healthy control subjects were compared in this study. The Childhood Trauma Questionnaire (CTQ), Hamilton Depressive Rating Scale (HAMD), Self-Rating Depression Scale (SDS), and Dysfunctional Attitude Scale (DAS) were used to evaluate each subject. High-resolution T1-weighted 3T magnetic resonance imaging scans and a whole-brain optimized voxel-based morphometry (VBM) approach were also used. Compared with healthy controls, the depressive group of subjects with childhood neglect showed significantly lower white-matter densities in the bilateral inferior parietal lobe (IPL) [43 -32 24] [-42 -42 25], whereas the depressive group without childhood neglect showed significantly lower densities in bilateral sub-lobar extra-nuclear white matter [27 -15 16] [-27 32 4]. White-matter densities in the bilateral sub-lobar extra-nuclear [-25 -17 18] [27 -13 20] and right brainstem midbrain [9 -34 -13] regions were higher in the depressive patients with childhood neglect than in the depressive patients without childhood neglect. White-matter densities in the bilateral inferior parietal lobe were negatively correlated with neglect total scores on the CTQ and with HAMD and DAS scores. White-matter densities in the bilateral sub-lobar extra-nuclear region were only negatively correlated with HAMD scores. Subjects that have depression with or without childhood neglect show different white-matter microstructural abnormalities.

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Authors
Peng, H., Ning, Y., Zhang, Y., Yang, H., Zhang, L., He, Z., Li, Z., Wang, L., Lu, S., Zhou, J., Zhang, Z., & Li, L.
Affiliations
  • Guangzhou Psychiatric Hospital (CN)
  • Second Xiangya Hospital of Central South University (CN)
  • Zhongda Hospital Southeast University (CN)
  • Chinese University of Hong Kong (HK)
ORCID
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2013-08
Volume
550
Pages
23-28
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/j.neulet.2013.06.048
OpenAlex
W1982510788
Cited by
21
References
38
Citations by year
2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 3
FWCI
1.85
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (30830046, 81171286)
  • The National Science and Technology Program of China (2007BAI17B02)
  • National 973 Program of China (2009CB918303, 2007CB512308)
  • Program of Chinese Ministry of Education (20090162110011)
  • Science and Technology Program of Guangzhou, China (2010Y1-C631)
  • The Science and Technology Program of Guangdong, China (2012B031800015)
  • National Hi-Tech Research and Development Program of China (2008AA02Z413)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
child neglect, child abuse, depression, white matter density, white matter microstructure, inferior parietal lobule, Childhood Trauma Questionnaire
MeSH terms
Adolescent, Adult, Brain, Brain Mapping, Depressive Disorder, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Surveys and Questionnaires, Adult Survivors of Child Abuse

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