Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls
Open accessAbstract
Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor. We also studied the effects of childhood and recent psychological distress on telomere length. We utilized samples from the nationally representative population-based Health 2000 Survey that was carried out between 2000-2001 in Finland to assess major public health problems and their determinants. We measured the relative telomere length of the peripheral blood cells by quantitative real-time PCR from 321 individuals with DSM-IV anxiety disorder or subthreshold diagnosis and 653 matched controls aged 30-87 years, who all had undergone the Composite International Diagnostic Interview. While telomere length did not differ significantly between cases and controls in the entire cohort, the older half of the anxiety disorder patients (48-87 years) exhibited significantly shorter telomeres than healthy controls of the same age (P = 0.013). Interestingly, shorter telomere length was also associated with a greater number of reported childhood adverse life events, among both the anxiety disorder cases and controls (P = 0.005). Childhood chronic or serious illness was the most significantly associated single event affecting telomere length at the adult age (P = 0.004). Self-reported current psychological distress did not affect telomere length. Our results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age. This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Kananen et al. found LTL was significantly shorter among the older anxiety disorder subjects (48-87 years of age) compared to controls.
“However, LTL was significantly shorter among the older anxiety disorder subjects (48–87 years of age) compared to controls, and the authors suggested that more prolonged exposure to anxiety disorder-related stress might be needed for accelerated telomere shortening to be detected (Kananen et al., 2010).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Kananen et al., 2010
Kananen et al. suggested that more prolonged exposure to anxiety disorder-related stress might be needed for accelerated telomere shortening to be detected.
“However, LTL was significantly shorter among the older anxiety disorder subjects (48–87 years of age) compared to controls, and the authors suggested that more prolonged exposure to anxiety disorder-related stress might be needed for accelerated telomere shortening to be detected (Kananen et al., 2010).”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Kananen et al., 2010
Kananen et al. (2010) found no overall significant difference in LTL between a mixed group of anxiety disorder subjects and controls.
“Kananen et al. (2010), found no overall significant difference in LTL between a mixed group of anxiety disorder subjects (panic disorder, generalized anxiety disorder, social phobia, agoraphobia and phobia not otherwise specified, plus cases of “sub-threshold” anxiety disorders not meeting DSM-IV criteria for anxiety disorder diagnosis) and controls.”
From Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging (2015) · cites this paper as Kananen et al. (2010)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR )
Segal, D. L. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0271 · Cited by 4,683 · see citing works
Telomere measurement by quantitative PCR
Cawthon, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e47 · Cited by 3,492 · see citing works
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works
Oxidative stress shortens telomeres
von Zglinicki, T. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02110-2 · Cited by 2,524 · see citing works
Green, J. G., McLaughlin, K. A., Berglund, P. A., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.186 · Cited by 2,323 · see citing works
Telomeres and human disease: ageing, cancer and beyond
Blasco, M. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1656 · Cited by 1,690 · see citing works
Obesity, cigarette smoking, and telomere length in women
Valdes, A., Andrew, T., Gardner, J., Kimura, M., Oelsner, E., Cherkas, L., Aviv, A., & Spector, T. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66630-5 · Cited by 1,363 · see citing works
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773 · see citing works
Brouilette, S., Moore, J. S., McMahon, A. D., Thompson, J. R., Ford, I., Shepherd, J., Packard, C. J., & Samani, N. J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60071-3 · Cited by 744 · see citing works
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 741 · see citing works
Telomere Length as an Indicator of Biological Aging
Bénétos, A., Okuda, K., Lajemi, M., Kimura, M., Thomas, F., Skurnick, J., Labat, C., Bean, K., & Aviv, A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.381 · Cited by 621 · see citing works
Aromaa, A. J., & Koskinen, S. V. P. (2004) · Cited by 583 · see citing works
The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length
Cherkas, L. F. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2007.39 · Cited by 568 · see citing works
McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.187 · Cited by 528 · see citing works
Oxidative stress markers in bipolar disorder: A meta-analysis
Andreazza, A. C., Kauer-Sant'Anna, M., Frey, B. N., Bond, D. J., Kapczinski, F., Young, L. T., & Yatham, L. N. (2008) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.04.013 · Cited by 526 · see citing works
Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.004 · Cited by 516 · see citing works
Demissie, S., Levy, D., Benjamin, E. J., Cupples, L. A., Gardner, J. P., Herbert, A., Kimura, M., Larson, M. G., Meigs, J. B., Keaney, J. F., et al. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00224.x · Cited by 508 · see citing works
Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
Hovatta, I., Tennant, R. S., Helton, R., Marr, R. A., Singer, O., Redwine, J. M., Ellison, J. A., Schadt, E. E., Verma, I. M., Lockhart, D. J., et al. (2005) · Nature · doi:10.1038/nature04250 · Cited by 498 · see citing works
Cell aging in relation to stress arousal and cardiovascular disease risk factors
Epel, E. S., Lin, J., Wilhelm, F. H., Wolkowitz, O. M., Cawthon, R., Adler, N. E., Dolbier, C., Mendes, W. B., & Blackburn, E. H. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.08.011 · Cited by 450 · see citing works
Increased telomerase activity and comprehensive lifestyle changes: a pilot study
Ornish, D., Lin, J., Daubenmier, J., Weidner, G., Epel, E., Kemp, C., Magbanua, M. J. M., Marlin, R., Yglecias, L., Carroll, P. R., et al. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70234-1 · Cited by 430 · see citing works
Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt‐Glaser, J. K., Nguyen, H., Laskowski, B. F., Zou, Y., Beversdorf, D. Q., & Weng, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4249 · Cited by 413 · see citing works
Pirkola, S. P., Isometsä, E. T., Suvisaari, J., Aro, H. M., Joukamaa, M. I., Poikolainen, K., Koskinen, S. V. P., Aromaa, A., & nnqvist, J. L. (2004) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-005-0848-7 · Cited by 410 · see citing works
Impact of psychiatric disorders on health-related quality of life: general population survey
Saarni, S. I., Suvisaari, J., Sintonen, H., Pirkola, S. P., Koskinen, S. V. P., Aromaa, A., & Lönnqvist, J. K. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.025106 · Cited by 371 · see citing works
Rise in Insulin Resistance Is Associated With Escalated Telomere Attrition
Gardner, J. P., Li, S., Srinivasan, S. R., Chen, W., Kimura, M., Lu, X., Berenson, G. S., & Aviv, A. (2005) · Circulation · doi:10.1161/01.cir.0000163550.70487.0b · Cited by 361 · see citing works
Carter, R., Wittchen, H., Pfister, H., & Kessler, R. (2001) · Depression and Anxiety · doi:10.1002/da.1020 · Cited by 345 · see citing works
Common variants near TERC are associated with mean telomere length
Wellcome Trust Case Control Consortium, Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.532 · Cited by 344 · see citing works
Monocyte Telomere Shortening and Oxidative DNA Damage in Type 2 Diabetes
Sampson, M., Winterbone, M. S., Hughes, J. C., Dozio, N., & Hughes, D. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1715 · Cited by 344 · see citing works
Tyrka, A. R., Price, L. H., Kao, H.-T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.014 · Cited by 342 · see citing works
Telomere shortening in smokers with and without COPD
Morlá, M., Busquets, X., Pons, J., Sauleda, J., MacNee, W., & Agustí, A. G. N. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00087005 · Cited by 326 · see citing works
MOFFITT, T. E., CASPI, A., HARRINGTON, H., MILNE, B. J., MELCHIOR, M., GOLDBERG, D., & POULTON, R. (2007) · Psychological Medicine · doi:10.1017/s0033291706009640 · Cited by 326 · see citing works
Martin-Ruiz, C. M., Gussekloo, J., van Heemst, D., von Zglinicki, T., & Westendorp, R. G. J. (2005) · Aging Cell · doi:10.1111/j.1474-9726.2005.00171.x · Cited by 314 · see citing works
Telomere length predicts survival independent of genetic influences
Bakaysa, S. L., Mucci, L. A., Slagboom, P. E., Boomsma, D. I., McClearn, G. E., Johansson, B. E. A., & Pedersen, N. L. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00340.x · Cited by 304 · see citing works
Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study
Aviv, A., Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., & Berenson, G. S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn338 · Cited by 290 · see citing works
Telomere Length and Mortality: A Study of Leukocytes in Elderly Danish Twins
Kimura, M., Hjelmborg, J., Gardner, J. P., Bathum, L., Brimacombe, M. B., Lu, X., Christiansen, L., Vaupel, J. W., Aviv, A., & Christensen, K. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm380 · Cited by 275 · see citing works
Mapping of a Major Locus that Determines Telomere Length in Humans
Vasa-Nicotera, M., Brouilette, S., Mangino, M., Thompson, J. R., Braund, P., Clemitson, J.-R., Mason, A., Bodycote, C. L., Raleigh, S. M., Louis, E., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/426734 · Cited by 257 · see citing works
Njajou, O. T., Hsueh, W.-C., Blackburn, E. H., Newman, A. B., Wu, S.-H., Li, R., Simonsick, E. M., Harris, T. B., Cummings, S., & Cawthon, R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp061 · Cited by 249 · see citing works
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?: Figure 1.
Eisch, A. J., Cameron, H. A., Encinas, J. M., Meltzer, L. A., Ming, G., & Overstreet‐Wadiche, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3798-08.2008 · Cited by 247 · see citing works
Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice
Masood, A., Nadeem, A., Mustafa, S. J., & O’Donnell, J. M. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.137208 · Cited by 225 · see citing works
Shortened telomere length in white blood cells of patients with IDDM.
Jeanclos, E., Krolewski, A., Skurnick, J., Kimura, M., Aviv, H., Warram, J. H., & Aviv, A. (1998) · Diabetes · doi:10.2337/diabetes.47.3.482 · Cited by 217 · cited 1× · see citing works
“Telomere length might be affected by several biological and lifestyle factors, including body mass index (BMI) [7,30,31], smoking [7,32], homocysteine levels [33], cardiovascular disease risk factors [8,9,34–37], insulin levels or resistance [10,38,39], diagnosis of diabetes [40,41], sleep duration [16], or physical i…”
BackgroundStress impacts telomere dynamics
Kotrschal, A., Ilmonen, P., & Penn, D. J. (2007) · Biology Letters · doi:10.1098/rsbl.2006.0594 · Cited by 208 · see citing works
Evidence that oxidative stress is linked to anxiety-related behaviour in mice
Rammal, H., Bouayed, J., Younos, C., & Soulimani, R. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.06.005 · Cited by 204 · see citing works
Methodology report : Health 2000 survey
Heistaro, S. (2008) · STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) · Cited by 195 · see citing works
Obesity and Weight Gain in Adulthood and Telomere Length
Kim, S., Parks, C. G., DeRoo, L. A., Chen, H., Taylor, J. A., Cawthon, R., & Sandler, D. P. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0935 · Cited by 190 · see citing works
Telomere Length Is Associated With Obesity Parameters but With a Gender Difference
Nordfjäll, K., Eliasson, M., Stegmayr, B., Melander, O., Nilsson, P. M., & Roos, G. (2008) · Obesity · doi:10.1038/oby.2008.413 · Cited by 188 · see citing works
The Individual Blood Cell Telomere Attrition Rate Is Telomere Length Dependent
Nordfjäll, K., Svenson, U., Norrback, K., Adolfsson, R., Lenner, P., & Roos, G. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000375 · Cited by 184 · see citing works
Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis
Ferrón, S. R., Marqués-Torrejón, M. Á., Mira, H., Flores, I., Taylor, K., Blasco, M. A., & Fariñas, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3836-09.2009 · Cited by 179 · see citing works
Telomere Length, Current Perceived Stress, and Urinary Stress Hormones in Women
Parks, C. G., Miller, D. B., McCanlies, E. C., Cawthon, R., Andrew, M. E., DeRoo, L. A., & Sandler, D. P. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0614 · Cited by 176 · see citing works
Hettema, J. M., An, S., Neale, M. C., Bukszár, J., van den Oord, E. J. C. G., Kendler, K. S., & Chen, X. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001845 · Cited by 175 · see citing works
de Souza, C. G., Moreira, J. D., Siqueira, I. R., Pereira, A. G., Rieger, D. K., Souza, D. O., Souza, T. M. E., Portela, L. V., & Perry, M. L. S. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.05.001 · Cited by 168 · see citing works
Childhood adversities as risk factors for adult mental disorders: Results from the Health 2000 study
Pirkola, S., Isometsä, E., Aro, H., Kestilä, L., Hämäläinen, J., Veijola, J., Kiviruusu, O., & Lönnqvist, J. (2005) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-005-0950-x · Cited by 167 · see citing works
Aviv, A., Valdes, A. M., Gardner, J. P., Swaminathan, R., Kimura, M., & Spector, T. D. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1814 · Cited by 167 · see citing works
O’Donovan, A., Lin, J., Dhabhar, F. S., Wolkowitz, O., Tillie, J. M., Blackburn, E., & Epel, E. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.11.006 · Cited by 161 · see citing works
Bandelow, B., Torrente, A. C., Wedekind, D., Broocks, A., Hajak, G., & R�ther, E. (2004) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-004-0521-2 · Cited by 158 · see citing works
Tarry‐Adkins, J. L., Martin‐Gronert, M. S., Chen, J. H., Cripps, R. L., & Ozanne, S. E. (2008) · The FASEB Journal · doi:10.1096/fj.07-099523 · Cited by 146 · see citing works
Hettema, J. M., An, S., Neale, M. C., Bukszár, J., van den Oord, E. J. C. G., Kendler, K. S., & Chen, X.-X. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001858 · Cited by 137 · see citing works
Short Telomeres and Prognosis of Hypertension in a Chinese Population
Yang, Z., Huang, X., Jiang, H., Zhang, Y., Liu, H., Qin, C., Eisner, G. M., José, P. A., Rudolph, K. L., & Ju, Z. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.123752 · Cited by 131 · see citing works
DEOLIVEIRA, M., SILVESTRIN, R., MELLOESOUZA, T., & MOREIRA, J. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.07.008 · Cited by 130 · see citing works
Rapid telomere erosion in schizophrenia
Kao, H.-T., Cawthon, R. M., DeLisi, L. E., Bertisch, H. C., Ji, F., Gordon, D., Li, P., Benedict, M. M., Greenberg, W. M., & Porton, B. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002105 · Cited by 128 · see citing works
Neurobiology of Schizophrenia Spectrum Disorders: The Role of Oxidative Stress
Wood, S. J., Yücel, M., Pantelis, C., & Berk, M. (2009) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v38n5p396 · Cited by 127 · see citing works
Goodwin, R. D., Fergusson, D. M., & Horwood, L. J. (2004) · Psychological Medicine · doi:10.1017/s0033291704003265 · Cited by 105 · see citing works
Short telomeres in patients with chronic schizophrenia who show a poor response to treatment
Yu, W., Chang, H., Lin, C., & Cho, C.-L. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0825 · Cited by 96 · see citing works
Homocysteine levels and leukocyte telomere length
Richards, J. B., Valdes, A. M., Gardner, J. P., Kato, B. S., Siva, A., Kimura, M., Lu, X., Brown, M. J., Aviv, A., & Spector, T. D. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.12.035 · Cited by 94 · see citing works
Molecular genetics of anxiety in mice and men
Hovatta, I., & Barlow, C. (2008) · Annals of Medicine · doi:10.1080/07853890701747096 · Cited by 90 · see citing works
The Heritability of Telomere Length Among the Elderly and Oldest-Old
Bischoff, C., Graakjær, J., Petersen, H. C., Hjelmborg, J., Vaupel, J. W., Bohr, V. A., Kølvraa, S., & Christensen, K. (2005) · Twin Research and Human Genetics · doi:10.1375/183242705774310141 · Cited by 89 · see citing works
Subthreshold depressive and anxiety disorders in the elderly.
Heun, R., Papassotiropoulos, A., & Ptok, U. (2000) · European psychiatry · doi:10.1016/s0924-9338(00)00228-5 · Cited by 84 · see citing works
The Heritability of Telomere Length Among the Elderly and Oldest-Old
Bischoff, C., Graakjær, J., Petersen, H. C., et al. (2005) · Twin Research and Human Genetics · doi:10.1375/twin.8.5.433 · Cited by 75 · see citing works
Obana, N., Takagi, S., Kinouchi, Y., Tokita, Y., Sekikawa, A., Takahashi, S., Hiwatashi, N., Oikawa, S., & Shimosegawa, T. (2003) · Internal Medicine · doi:10.2169/internalmedicine.42.150 · Cited by 63 · see citing works
Donner, J., Pirkola, S. P., Silander, K., Kananen, L., Terwilliger, J. D., Lönnqvist, J. K., Peltonen, L., & Hovatta, I. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.002 · Cited by 60 · see citing works
Telomere Attrition in White Blood Cell Correlating with Cardiovascular Damage
NAKASHIMA, H., Ozono, R., SUYAMA, C., Sueda, T., Kambe, M., & Oshima, T. (2004) · Hypertension Research · doi:10.1291/hypres.27.319 · Cited by 58 · see citing works
Telomere length and psychological well-being in patients with chronic heart failure
Huzen, J., van der Harst, P., de Boer, R. A., Lesman‐Leegte, I., Voors, A. A., van Gilst, W. H., Samani, N. J., Jaarsma, T., & van Veldhuisen, D. J. (2010) · Age and Ageing · doi:10.1093/ageing/afp256 · Cited by 58 · see citing works
Telomere shortening in smokers with and without COPD
Morlá, M., Busquets, X., Pons, J., Sauleda, J., MacNee, W., & Agustí, A. G. N. (2006) · Respiratory Medicine COPD Update · doi:10.1016/j.rmedu.2006.03.022 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Adverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140 · see citing works
Paradise lost: the neurobiological and clinical consequences of child abuse and neglect
Nemeroff, C. B. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.019 · Cited by 768 · see citing works
Shalev, I., Moffitt, T. E., Sugden, K., Williams, B., Houts, R. M., Danese, A., Mill, J., Arseneault, L., & Caspi, A. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.32 · Cited by 489 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works
Ageing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 386 · see citing works
Stressful early life experiences and immune dysregulation across the lifespan
Fagundes, C. P., Glaser, R., & Kiecolt-Glaser, J. K. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.014 · Cited by 371 · see citing works
The roles of senescence and telomere shortening in cardiovascular disease
Fyhrquist, F., Saijonmaa, O. J., & Strandberg, T. E. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.30 · Cited by 368 · see citing works
Oxidative stress in anxiety and comorbid disorders
Hovatta, I., Juhila, J., & Donner, J. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.08.007 · Cited by 365 · see citing works
Telomeres and early-life stress: an overview
Price, L. H., Kao, H.-T., Burgers, D. E., Carpenter, L. L., & Tyrka, A. R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.06.025 · Cited by 339 · see citing works
Needham, B. L., Adler, N. E., Gregorich, S. E., Rehkopf, D. H., Lin, J., Blackburn, E. H., & Epel, E. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.023 · Cited by 325 · see citing works
Telomere length and early severe social deprivation: linking early adversity and cellular aging
Drury, S. S., Theall, K., Gleason, M. M., Smyke, A. T., De Vivo, I., Wong, J. Y. Y., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.53 · Cited by 316 · see citing works
Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.007 · Cited by 285 · see citing works
Early life adversity and telomere length: a meta-analysis
Ridout, K. K., Levandowski, M., Ridout, S. J., Gantz, L., Goonan, K., Palermo, D., Price, L. H., & Tyrka, A. R. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.26 · Cited by 273 · see citing works
Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder
O'Donovan, A., Epel, E., Lin, J., Wolkowitz, O., Cohen, B., Maguen, S., Metzler, T., Lenoci, M., Blackburn, E., & Neylan, T. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.035 · Cited by 262 · see citing works
Mathur, M. B., Epel, E., Kind, S., Desai, M., Parks, C. G., Sandler, D. P., & Khazeni, N. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.002 · Cited by 252 · see citing works
Telomeres and lifestyle factors: Roles in cellular aging.
Lin, J., Epel, E., & Blackburn, E. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.08.003 · Cited by 251 · see citing works
Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample
Geronimus, A. T., Pearson, J. A., Linnenbringer, E. L., Schulz, A. J., Reyes, A. G., Epel, E. S., Lin, J., & Blackburn, E. H. (2015) · Journal of Health and Social Behavior · doi:10.1177/0022146515582100 · Cited by 250 · see citing works
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length
Entringer, S., Epel, E. S., Lin, J., Buß, C., Shahbaba, B., Blackburn, E. H., Simhan, H. N., & Wadhwa, P. D. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.11.033 · Cited by 249 · see citing works
Basic Biology of Oxidative Stress and the Cardiovascular System
Sack, M. N., Fyhrquist, F., Saijonmaa, O. J., Fuster, V., & Kovacic, J. C. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.034 · Cited by 243 · see citing works
Moffitt, T. E., & Tank, T. K.-G. 2. T. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000801 · Cited by 239 · see citing works
Darrow, S. M., Verhoeven, J. E., Révész, D., Lindqvist, D., Penninx, B. W. J. H., Delucchi, K. L., Wolkowitz, O. M., & Mathews, C. A. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000356 · Cited by 229 · see citing works
Starkweather, A. R., Alhaeeri, A. A., Montpetit, A. J., Brumelle, J., Filler, K., Montpetit, M., Mohanraj, L., Lyon, D., & Jackson‐Cook, C. K. (2013) · Nursing Research · doi:10.1097/nnr.0000000000000009 · Cited by 217 · see citing works
Of sound mind and body: depression, disease, and accelerated aging
Wolkowitz, O. M., Reus, V. I., & Mellon, S. H. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/owolkowitz · Cited by 213 · see citing works
An experimental demonstration that early-life competitive disadvantage accelerates telomere loss
Nettle, D., Monaghan, P., Gillespie, R., Brilot, B., Bedford, T., & Melissa Bateson, B. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.1610 · Cited by 202 · see citing works
The fetal programming of telomere biology hypothesis: an update
Entringer, S., de Punder, K., Buß, C., & Wadhwa, P. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0151 · Cited by 189 · see citing works
The effects of early life adversity on the immune system
Elwenspoek, M. M. C., Kuehn, A., Muller, C. P., & Turner, J. D. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.012 · Cited by 180 · see citing works
Long-term lithium treatment in bipolar disorder is associated with longer leukocyte telomeres
Martinsson, L., Wei, Y., Xu, D., Melas, P. A., Mathé, A. A., Schalling, M., Lavebratt, C., & Backlund, L. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.37 · Cited by 179 · see citing works
Theall, K. P., Brett, Z. H., Shirtcliff, E. A., Dunn, E. C., & Drury, S. S. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.02.030 · Cited by 175 · see citing works
Wikgren, M., Maripuu, M., Karlsson, T., Nordfjäll, K., Bergdahl, J., Hultdin, J., Del‐Favero, J., Roos, G., Nilsson, L., Adolfsson, R., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.015 · Cited by 173 · see citing works
Gielen, M., Hageman, G. J., Antoniou, E. E., Nordfjäll, K., Mangino, M., Balasubramanyam, M., Meyer, T. D., Hendricks, A. E., Giltay, E. J., Hunt, S. C., et al. (2018) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy107 · Cited by 168 · see citing works
Polvi, A., Linnankivi, T., Kivelä, T., Herva, R., Keating, J., Mäkitie, O., Pareyson, D., Vainionpää, L. K., Lahtinen, J., Hovatta, I., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.02.002 · Cited by 172 · see citing works
Lengacher, C. A., Reich, R. R., Kip, K. E., Barta, M., Ramesar, S., Paterson, C. L., Moscoso, M. S., Carranza, I., Budhrani, P. H., Kim, S. J., et al. (2014) · Biological Research For Nursing · doi:10.1177/1099800413519495 · Cited by 169 · see citing works
Heim, C. M., Entringer, S., & Buss, C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.011 · Cited by 158 · see citing works
Oliveira, B. S., Zunzunegui, M. V., Quinlan, J., Fahmi, H., Tu, M. T., & Guerra, R. O. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.12.006 · Cited by 159 · see citing works
Rickard, I. J., Frankenhuis, W. E., & Nettle, D. (2014) · Perspectives on Psychological Science · doi:10.1177/1745691613513467 · Cited by 148 · see citing works
Early life stress and telomere length: Investigating the connection and possible mechanisms
Shalev, I. (2012) · BioEssays · doi:10.1002/bies.201200084 · Cited by 147 · see citing works
O’Donovan, A., Slavich, G. M., Epel, E. S., & Neylan, T. C. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.10.013 · Cited by 148 · see citing works
Bojesen, S. E. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12083 · Cited by 141 · see citing works
The Association of Telomere Length With Family Violence and Disruption
Drury, S. S., Mabile, E., Brett, Z. H., Esteves, K. C., Jones, E., Shirtcliff, E. A., & Theall, K. P. (2014) · PEDIATRICS · doi:10.1542/peds.2013-3415 · Cited by 141 · see citing works
Elvsåshagen, T., Vera, E., Bøen, E., Bratlie, J., Andreassen, O. A., Josefsen, D., Malt, U. F., Blasco, M. A., & Boye, B. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.006 · Cited by 133 · see citing works
Asok, A., Bernard, K., Roth, T. L., Rosen, J. B., & Dozier, M. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000011 · Cited by 128 · see citing works
Gassen, N. C., Chrousos, G. P., Binder, E. B., & Zannas, A. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.003 · Cited by 124 · see citing works
Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Reus, V. I., Rosser, R., Burke, H., Compagnone, M., Nelson, J. C., Dhabhar, F. S., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.133 · Cited by 125 · see citing works
Steptoe, A., Hamer, M., Butcher, L., Lin, J., Brydon, L., Mika Kivimaki, B., Marmot, M. G., Blackburn, E. H., & Erusalimsky, J. D. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.04.010 · Cited by 123 · see citing works
Is Socioeconomic Status Associated With Biological Aging as Measured by Telomere Length?
Robertson, T., Batty, G. D., Der, G., Fenton, C., Shiels, P. G., & Benzeval, M. (2012) · Epidemiologic Reviews · doi:10.1093/epirev/mxs001 · Cited by 117 · see citing works
Loving-kindness meditation practice associated with longer telomeres in women
Hoge, E. A., Chen, M. M., Orr, E., Metcalf, C. A., Fischer, L. E., Pollack, M. H., DeVivo, I., & Simon, N. M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.04.005 · Cited by 116 · see citing works
Socioeconomic status and cell aging in children
Needham, B. L., Fernández, J. R., Lin, J., Epel, E. S., & Blackburn, E. H. (2012) · Social Science & Medicine · doi:10.1016/j.socscimed.2012.02.019 · Cited by 115 · see citing works
Early Life Epidemiology of Alzheimer's Disease - A Critical Review
Seifan, A., Schelke, M. W., Obeng-Aduasare, Y., & Isaacson, R. (2015) · Neuroepidemiology · doi:10.1159/000439568 · Cited by 110 · see citing works
Surtees, P. G., Wainwright, N. W. J., Pooley, K. A., Luben, R., Khaw, K., Easton, D. F., & Dunning, A. M. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr112 · Cited by 111 · see citing works
Telomeres, Telomerase and Ageing
Saretzki, G. C. (2018) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-2835-0_9 · Cited by 114 · see citing works
Puterman, E., & Epel, E. (2012) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2012.00465.x · Cited by 106 · see citing works
Work-Related Exhaustion and Telomere Length: A Population-Based Study
Ahola, K., Sirén, I., Mika Kivimaki, B., Ripatti, S., Aromaa, A., Lönnqvist, J. K., & Hovatta, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040186 · Cited by 96 · see citing works
The relationship between childhood psychosocial stressor level and telomere length: a meta-analysis
M. Hanssen, L., S. Schutte, N., M. Malouff, J., & S. Epel, E. (2017) · Health Psychology Research · doi:10.4081/hpr.2017.6378 · Cited by 93 · see citing works
“…compared participants in categories of amount of childhood psychosocial stressors, such as high or low exposure to stressors (e.g., Tyrka et al., 2015) Many studies (e.g., Kananen et al., 2010) used measures relying on retrospective memory of participants or others, such as parents, of past events.”
BackgroundAre Anxiety Disorders Associated with Accelerated Aging? A Focus on Neuroprogression
Perna, G., Iannone, G., Alciati, A., & Caldirola, D. (2015) · Neural Plasticity · doi:10.1155/2016/8457612 · Cited by 96 · see citing works
Nettle, D., Andrews, C. P., Reichert, S., Bedford, T., Kolenda, C., Parker, C., Martin-Ruiz, C. M., Monaghan, P., & Melissa Bateson, B. (2017) · Scientific Reports · doi:10.1038/srep40794 · Cited by 92 · see citing works
Leukocyte telomere length and its relation to food and nutrient intake in an elderly population
Tiainen, A.-M., Männistö, S., Blomstedt, P., Moltchanova, E. V., Perälä, M.-M., Kaartinen, N. E., Kajantie, E., Kananen, L., Hovatta, I., & Eriksson, J. G. (2012) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2012.143 · Cited by 92 · see citing works
Adverse Childhood Events and Health Biomarkers: A Systematic Review
Soares, S., Rocha, V., Kelly‐Irving, M., Stringhini, S., & Fraga, S. J. D. S. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.649825 · Cited by 91 · see citing works
Hoen, P. W., Rosmalen, J. G. M., Schoevers, R. A., Huzen, J., van der Harst, P., & de Jonge, P. (2013) · Psychological Medicine · doi:10.1017/s0033291712001766 · Cited by 88 · see citing works
Molecular Mechanisms Involved in the Aging of the T-cell Immune Response
Moro‐García, M. A., Alonso‐Arias, R., & López‐Larrea, C. (2012) · Current Genomics · doi:10.2174/138920212803759749 · Cited by 85 · see citing works
Prescott, J., Du, M., Wong, J. Y. Y., Han, J., & Vivo, I. D. (2012) · Human Reproduction · doi:10.1093/humrep/des314 · Cited by 86 · see citing works
Low Social Support Is Associated With Shorter Leukocyte Telomere Length in Late Life
Carroll, J., Roux, A. V. D., Fitzpatrick, A. L., & Seeman, T. E. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31828233bf · Cited by 84 · see citing works
Telomere shortening in formerly abused and never abused women.
Humphreys, J., Epel, E. S., Cooper, B. A., Lin, J., Blackburn, E. H., & Lee, K. A. (2012) · Biological Research For Nursing · doi:10.1177/1099800411398479 · Cited by 97 · see citing works
Immune and Epigenetic Pathways Linking Childhood Adversity and Health Across the Lifespan
Chen, M. A., LeRoy, A. S., Majd, M., Chen, J. Y., Brown, R. L., Christian, L. M., & Fagundes, C. P. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.788351 · Cited by 85 · see citing works
The Association of Early and Recent Psychosocial Life Stress With Leukocyte Telomere Length
Verhoeven, J. E., van Oppen, P., Puterman, E. M., Elzinga, B. M., & Penninx, B. W. J. H. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000226 · Cited by 81 · see citing works
Nettle, D., Monaghan, P., Boner, W., Gillespie, R., & Melissa Bateson, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083617 · Cited by 81 · see citing works
Chronic pain, perceived stress, and cellular aging: an exploratory study.
Sibille, K. T., Langaee, T., Burkley, B., Gong, Y., Glover, T. L., King, C., Riley, J. L., Leeuwenburgh, C., Staud, R., Bradley, L. A., et al. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-12 · Cited by 80 · see citing works
Leukocyte Telomere Length in the Finnish Diabetes Prevention Study
Hovatta, I., de Mello, V. D., Kananen, L., Lindström, J., Eriksson, J. G., Ilanne‐Parikka, P., Keinanen-Kiukaanniemi, S. M., Peltonen, M., Tuomilehto, J. O., & Uusitupa, M. I. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034948 · Cited by 79 · see citing works
Doblhammer, G., van den Berg, G. J., & Fritze, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074915 · Cited by 12 · see citing works
Inflammation in the pathogenesis of depression: a disorder of neuroimmune origin
Corrigan, M., O’Rourke, A. M., Moran, B., Fletcher, J. M., & Harkin, A. (2023) · Neuronal Signaling · doi:10.1042/ns20220054 · Cited by 77 · see citing works
Osler, M., Bendix, L., Rask, L., & Rod, N. H. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.154 · Cited by 76 · see citing works
Innes, K. E., & Selfe, T. K. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00040 · Cited by 72 · see citing works
Dammering, F., Martins, J., Dittrich, K., Czamara, D., Rex‐Haffner, M., Overfeld, J., de Punder, K., Buß, C., Entringer, S., Winter, S., et al. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100394 · Cited by 75 · see citing works
Wulsin, L. R., Herman, J. P., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.12.010 · Cited by 73 · see citing works
Burke, S. L., Hu, T., Fava, N. M., Li, T., Rodriguez, M. J., Schuldiner, K. L., Burgess, A., & Laird, A. R. (2018) · Journal of Women & Aging · doi:10.1080/08952841.2018.1419476 · Cited by 74 · see citing works
Needham, B. L., Carroll, J., Roux, A. V. D., Fitzpatrick, A. L., Moore, K., & Seeman, T. E. (2014) · Health & Place · doi:10.1016/j.healthplace.2014.04.009 · Cited by 73 · see citing works
Joergensen, A., Broedbaek, K., Weimann, A., Semba, R. D., Ferrucci, L., Jørgensen, M. B., & Poulsen, H. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020795 · Cited by 71 · see citing works
High phobic anxiety is related to lower leukocyte telomere length in women
Okereke, O. I., Prescott, J., Wong, J. Y. Y., Han, J., Rexrode, K. M., & De Vivo, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040516 · Cited by 72 · see citing works
Pain is associated with short leukocyte telomere length in women with fibromyalgia
Hassett, A. L., Epel, E., Clauw, D. J., Harris, R. E., Harte, S. E., Kairys, A., Buyske, S., & Williams, D. A. (2012) · The Journal of Pain · doi:10.1016/j.jpain.2012.07.003 · Cited by 70 · see citing works
Savolainen, K., Eriksson, J. G., Kananen, L., Kajantie, E., Pesonen, A., Heinonen, K., & Räikkönen, K. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.02.002 · Cited by 70 · see citing works
Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms
Zannas, A. S. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/azannas · Cited by 69 · see citing works
Enlow, M. B., Bollati, V., Sideridis, G. D., Flom, J. D., Hoxha, M., Hacker, M. R., & Wright, R. J. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.025 · Cited by 68 · see citing works
Processes Linking Religious Involvement and Telomere Length
Hill, T. D., Vaghela, P., Ellison, C. G., & Rote, S. M. (2017) · Biodemography and Social Biology · doi:10.1080/19485565.2017.1311204 · Cited by 69 · see citing works
Telomere shortening in leukocyte subpopulations in depression
Karabatsiakis, A., Kolassa, I., Kolassa, S., Rudolph, K. L., & Dietrich, D. E. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-192 · Cited by 67 · see citing works
Chronic stress exposure and daily stress appraisals relate to biological aging marker p16INK4a
Rentscher, K. E., Carroll, J., Repetti, R. L., Cole, S. W., Reynolds, B. M., & Robles, T. F. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.006 · Cited by 69 · see citing works
Anxiety disorders and accelerated cellular ageing
Verhoeven, J. E., Révész, D., van Oppen, P., Epel, E. S., Wolkowitz, O. M., & Penninx, B. W. J. H. (2015) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.151027 · Cited by 68 · see citing works
Proinflammatory T Cell Status Associated with Early Life Adversity
Elwenspoek, M. M. C., Hengesch, X., Leenen, F. A. D., Schritz, A., Sias, K., Schaan, V., Mériaux, S. B., Schmitz, S., Bonnemberger, F., Schächinger, H., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701082 · Cited by 63 · see citing works
Longer telomere length in patients with schizophrenia
Nieratschker, V., Lahtinen, J., Meier, S., Strohmaier, J., Frank, J., Heinrich, A., Breuer, R., Witt, S. H., Nöthen, M. M., Rietschel, M., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.06.043 · Cited by 63 · see citing works
Verhoeven, J. E., van Oppen, P., Révész, D., Wolkowitz, O. M., & Penninx, B. W. J. H. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15070887 · Cited by 63 · see citing works
No association between mean telomere length and life stress observed in a 30 year birth cohort
Jodczyk, S., Fergusson, D. M., Horwood, L. J., Pearson, J. F., & Kennedy, M. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097102 · Cited by 62 · see citing works
Ladwig, K., Brockhaus, A. C., Baumert, J., Lukaschek, K., Emeny, R. T., Kruse, J., Codd, V., Häfner, S., Albrecht, E., Illig, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064762 · Cited by 63 · see citing works
The long-term impact of adverse caregiving environments on epigenetic modifications and telomeres
Blaze, J., Asok, A., & Roth, T. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00079 · Cited by 58 · see citing works
Analysis of telomere attrition in bipolar disorder
Lima, I. M. M., Barros, A. G. A., Rosa, D. V., Albuquerque, M. R., Malloy‐Diniz, L. F., Neves, F. S., Romano‐Silva, M. A., & de Miranda, D. M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.043 · Cited by 61 · see citing works
Maternal stress and social support prospectively predict infant inflammation
Nelson, B. W., Wright, D. B., Allen, N. B., & Laurent, H. K. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.05.010 · Cited by 58 · see citing works
Against All Odds: Genocidal Trauma Is Associated with Longer Life-Expectancy of the Survivors
Sagi‐Schwartz, A., Bakermans‐Kranenburg, M. J., Linn, S., & van IJzendoorn, M. H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069179 · Cited by 56 · see citing works
A meta-analysis of the relationship between anxiety and telomere length
Malouff, J. M., & Schutte, N. S. (2016) · Anxiety Stress & Coping · doi:10.1080/10615806.2016.1261286 · Cited by 56 · see citing works
Phillips, A. C., Robertson, T., Carroll, D., Der, G., Shiels, P. G., McGlynn, L., & Benzeval, M. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318289e6b5 · Cited by 55 · see citing works
Brody, G. H., Yu, T., Beach, S. R. H., & Philibert, R. A. (2014) · Prevention Science · doi:10.1007/s11121-014-0474-2 · Cited by 55 · see citing works
Vincent, J. B., Hovatta, I., Frissa, S., Goodwin, L., Hotopf, M. H., Hatch, S. L., Breen, G. D., & Powell, T. R. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.01.031 · Cited by 54 · see citing works
Developmental neuroplasticity and the origin of neurodegenerative diseases
Schaefers, A. T. U., & Teuchert, G. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.797104 · Cited by 54 · see citing works
Schury, K., & Kolassa, I. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06617.x · Cited by 53 · see citing works
- Authors
- Kananen, L., Surakka, I., Pirkola, S., Suvisaari, J., Lönnqvist, J., Peltonen, L., Ripatti, S., & Hovatta, I.
- Affiliations
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Finnish Institute for Health and Welfare (FI)
- Broad Institute (US)
- Corresponding author
- Hovatta, Iiris
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-05-25
- Volume
- 5
- Issue
- 5
- Pages
- e10826
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2876034
- OpenAlex
- W1986488389
- Cited by
- 270
- References
- 71
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 13 · 2020: 7 · 2019: 16 · 2018: 15 · 2017: 28 · 2016: 25 · 2015: 32 · 2014: 25 · 2013: 27 · 2012: 33
- FWCI
- 18.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Työväentutkimus Vuosikirja (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Academy of Finland
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- telomere length, childhood adversity, anxiety disorders, children with chronic illness, psychological distress, stress, aging, Health 2000 Survey
- MeSH terms
- Adult, Aging, Anxiety Disorders, Child, Child Abuse, Humans, Life Change Events, Socioeconomic Factors, Stress, Psychological, Case-Control Studies, Telomere
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
