Increased excretion of a lipid peroxidation biomarker in autism
Abstract
It is thought that autism could result from an interaction between genetic and environmental factors with oxidative stress as a potential mechanism linking the two. One genetic factor may be altered oxidative-reductive capacity. This study tested the hypothesis that children with autism have increased oxidative stress. We evaluated children with autism for the presence of two oxidative stress biomarkers. Urinary excretion of 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-isoprostane-F2alpha (8-iso-PGF2alpha) were determined in 33 children with autism and 29 healthy controls. 8-iso-PGF2alpha levels were significantly higher in children with autism. The isoprostane levels in autistic subjects were variable with a bimodal distribution. The majority of autistic subjects showed a moderate increase in isoprostane levels while a smaller group of autistic children showed dramatic increases in their isoprostane levels. There was a trend of an increase in 8-OHdG levels in children with autism but it did not reach statistical significance. There was no significant correlation between the levels of the biomarkers and vitamin intake, dietary supplements, medicine, medical disorders, or history of regression. These results suggest that the lipid peroxidation biomarker is increased in this cohort of autistic children, especially in the subgroup of autistic children.
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Oxidative stress might be a candidate mechanism linking genetic and environmental factors in genetic disorders associated with autism (149-151).
“oxidative stress might be a candidate mechanism linking genetic and environmental factors in genetic disorders associated with autism (149–151).”
From Gene × Environment Interactions in Autism Spectrum Disorders: Role of Epigenetic Mechanisms (2014) · cites this paper as [151]
Several lines of evidence indicate oxidative stress and mitochondrial dysfunction are prevalent in individuals with ASD.
“There are presently several lines of evidence indicating oxidative stress and mitochondrial dysfunction are prevalent in individuals with ASD [3,10,11,12,13,14,15,16].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [10]
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- Authors
- Ming, X., Stein, T. P., Brimacombe, M., Johnson, W. G., Lambert, G. H., & Wagner, G. C.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Rutgers New Jersey Medical School (US)
- Corresponding author
- Ming, X.
- Venue
- Prostaglandins, Leukotrienes and Essential Fatty Acids
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 73
- Issue
- 5
- Pages
- 379-384
- ISSN
- 0952-3278 (ISSN-L)
- OpenAlex
- W2113611591
- Cited by
- 236
- References
- 44
- Citations by year
- 2025: 9 · 2024: 7 · 2023: 2 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 9 · 2018: 13 · 2017: 11 · 2016: 12 · 2015: 11 · 2014: 18 · 2013: 16 · 2012: 9
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prostaglandins Leukotrienes and Essential Fatty Acids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r21ns043981-03)
- National Institute of Neurological Disorders and Stroke (NS 43981)
- National Institute of Environmental Health Sciences (ES 11256, ES-05022., P01ES011256, P30ES005022)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, oxidative stress, lipid peroxidation, 8-isoprostane, 8-hydroxy-2'-deoxyguanosine, urinary biomarkers, children, gene-environment interaction
- MeSH terms
- 8-Hydroxy-2'-Deoxyguanosine, Adolescent, Autistic Disorder, Child, Child, Preschool, Deoxyguanosine, Female, Humans, Male, Lipid Peroxidation, Dinoprost, Cohort Studies, Biomarkers, Oxidative Stress
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