The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Protective effect of the green tea component, l-theanine on environmental toxins-induced neuronal cell death
Abstract
Several environmental neurotoxins and oxidative stress inducers are known to damage the nervous system and are considered major factors associated with the selective vulnerability of nigral dopaminergic neurons in Parkinson's disease (PD). Gamma-glutamylethylamide (L-theanine), a natural glutamate analog in green tea, has been shown to exert strong anti-ischemic effect. In this study, we investigated the protective effects of L-theanine on neurotoxicity induced by PD-related neurotoxicants, rotenone and dieldrin in cultured human dopaminergic cell line, SH-SY5Y. Our initial experiments revealed that L-theanine (500 microM) attenuated both rotenone- and dieldrin-induced DNA fragmentation and apoptotic death in SH-SY5Y cells. In addition, L-theanine partially prevented both rotenone- and dieldrin-induced heme oxygenase-1 (HO-1) up-regulation. Both rotenone- and dieldrin-induced down-regulation of extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation was significantly blocked by pretreatment with L-theanine. Furthermore, pretreatment with L-theanine significantly attenuated the down-regulation of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) production in SH-SY5Y cells. These results suggest that L-theanine directly provide neuroprotection against PD-related neurotoxicants and may be clinically useful for preventing PD symptoms.
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“Functionally L-theanine especially crossing the blood brain barrier, is measurable in a range from 30 min and up to 5 h after ingestion [10,11,33]”
From l -theanine: A potential multifaceted natural bioactive amide as health supplement (2017) · cites this paper as [10]
Citations
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“L-Theanine also attenuated neurotoxicity of rotenone and dieldrin-induced DNA fragmentation and apoptotic death in cultured neural cells [38], as well as L-glutamate-induced amyloid beta neurotoxicity [39].”
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Womperski, K., Woźniak, J., Szymonik, J., Szopa, S., & Elias, J. (2024) · Quality in Sport · doi:10.12775/qs.2023.16.001 · Cited by 1
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Justin, S. (2020) · Journal of Toxicology and Environmental Health Sciences · doi:10.5897/jtehs2020.0468 · Cited by 1
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“2008), and the chlorinated insecticide dieldrin down regulates extracellular signalregulated kinase1/2 (ERK1/2) phosphorylation in cultured human dopaminergic cell line (Cho et al. 2008).”
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Niu, K., Huang, G., & Guo, H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384937-3.00116-6
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Prasanth, M. I., Sharika, R., Brimson, J. M., Malar, D. S., & Tencomnao, T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00040-3
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Lopez-Suarez, L. (2022) · theses.fr (ABES) · doi:10.70675/1e791dd5z5848z4ee2zb26ez089a2f5c505e
Metadata
- Authors
- Cho, H.-S., Kim, S., Lee, S.-Y., Park, J. A., Kim, S.-J., & Chun, H. S.
- Affiliations
- Chosun University (KR)
- Corresponding author
- Chun, Hong Sung
- Venue
- NeuroToxicology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 29
- Issue
- 4
- Pages
- 656-662
- ISSN
- 0161-813X (ISSN-L)
- OpenAlex
- W1974965926
- Cited by
- 138
- References
- 40
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 10 · 2020: 7 · 2019: 8 · 2018: 9 · 2017: 3 · 2016: 10 · 2015: 8 · 2014: 5 · 2013: 12 · 2012: 13
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroToxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Chosun University
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- theanine, green tea, Parkinson's disease, neuroprotection, rotenone, dieldrin, dopaminergic neurons, SH-SY5Y cells, apoptosis, DNA fragmentation, heme oxygenase-1, ERK1/2 phosphorylation, brain-derived neurotrophic factor, glial cell line-derived neurotrophic factor, neurotoxicity, oxidative stress
- MeSH terms
- Analysis of Variance, Cell Line, Transformed, Dieldrin, Dose-Response Relationship, Drug, Drug Interactions, Glutamates, Humans, Indoles, Insecticides, Nerve Growth Factors, Neurons, Rotenone, Apoptosis, Neuroprotective Agents, Heme Oxygenase-1
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