The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Oxidative imbalance in patients with mild cognitive impairment and Alzheimer’s disease
Abstract
Increasing evidence supports a role of oxidative imbalance, characterized by impaired antioxidant enzymatic activity and increased reactive oxygen species (ROS) production, in mild cognitive impairment (MCI) and Alzheimer's disease (AD) pathogenesis. Hyperhomocysteinemia, another risk factor for AD, also contributes to oxidative damage. Plasma total homocysteine (tHcy) and ROS levels, and total antioxidant capacity (TAC) were determined in 71 AD, 36 MCI and 28 vascular dementia (VaD) patients as well as in 44 age-matched controls. tHcy levels were significantly increased in patients with AD and VaD an a trend towards an increase in multiple domain MCI was observed. TAC was significantly decreased in AD as well as MCI, but not in VaD patients. In AD patients, a negative correlation was found between TAC and disease duration. ROS levels did not differ among groups, but were correlated with age. In conclusion, a pattern characterized by increased tHcy levels and decreased TAC is present in AD as well as MCI patients. While increased tHcy levels were also found in VaD, TAC modifications occur specifically in AD. ROS levels appear to be correlated with age rather than with a specific dementing disorder, thus leading to the hypothesis that oxidative imbalance observed in AD could be due to a decreased TAC.
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“Indeed, chemokines and cytokines increased levels in plasma and CSF are a very early event in AD pathogenesis, even preceding the clinical onset of the disease, as demonstrated by subjects with MCI who developed AD over time, representing a crucial step in the progression of the disease [117,118,119].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [117]
In the citing paper
“Total antioxidant capacity (TAC) (including glutathione, ascorbic acid, uric acid, and bilirubin) is measured in plasma samples from AD and MCI patients and has been found depleted [117].”
From Role of Oxidative Damage in Alzheimer’s Disease and Neurodegeneration: From Pathogenic Mechanisms to Biomarker Discovery (2021) · cites this paper as [117]
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Metadata
- Authors
- GUIDI, I., GALIMBERTI, D., LONATI, S., NOVEMBRINO, C., BAMONTI, F., TIRITICCO, M., FENOGLIO, C., VENTURELLI, E., BARON, P., & BRESOLIN, N.
- Affiliations
- University of Milan (IT)
- Corresponding author
- GALIMBERTI, D
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 27
- Issue
- 2
- Pages
- 262-269
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2152628887
- Cited by
- 203
- References
- 37
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 10 · 2020: 15 · 2019: 13 · 2018: 11 · 2017: 6 · 2016: 10 · 2015: 4 · 2014: 13 · 2013: 11 · 2012: 16
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidative imbalance, mild cognitive impairment, Alzheimer's disease, vascular dementia, hyperhomocysteinemia, total homocysteine, reactive oxygen species, total antioxidant capacity, antioxidant enzymes, oxidative stress, disease duration
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Apolipoproteins E, Cocaine, Cognition Disorders, Epinephrine, Female, Homocystine, Humans, Male, Mental Status Schedule, Middle Aged, Retrospective Studies, Sex Factors, Tetracaine, Confidence Intervals, Odds Ratio, Case-Control Studies, Reactive Oxygen Species, Apolipoprotein E4
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