Cited by 378Dementia and Cognitive Impairment ResearchAntioxidant Activity and Oxidative StressAlzheimer's disease research and treatments

Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease

Padurariu, Manuela, Ciobica, Alin, Hritcu, Lucian, Stoica, Bogdan, Bild, Walther, Stefanescu, Cristinel·2010·Neuroscience Letters

Abstract

Mild cognitive impairment (MCI) is a nosological entity proposed as an intermediate state between normal aging and dementia. MCI seems to represent an early stage of Alzheimer's disease (AD) and there is a great interest in the relationship between MCI and the progression to AD. Some studies have demonstrated an accumulation of products of free radical damage in the central nervous system and in the peripheral tissues of subjects with AD or mild cognitive impairment. The aim of the present work was to evaluate the serum levels of some enzymatic antioxidant defences like superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as lipid peroxidation markers like MDA (malondialdehyde), in MCI and AD patients, compared with age-matched healthy controls. The subjects of this study (45 patients) consisted of 15 individuals with mild cognitive impairment (MCI), 15 with Alzheimer's disease (AD) and 15 healthy age-matched controls. Biochemical analyses showed a similar decrease of the main enzymatic antioxidant defences (SOD and GPX) and increased production of lipid peroxidation marker (MDA) in the serum of the MCI and AD patients, compared to age-matched control group. This study clearly demonstrates that oxidative stress damage occurs in patients with MCI and AD. Moreover, some enzymatic markers of oxidative stress are similar in MCI and AD patients, suggesting that oxidative damage could be one important aspect for the onset of AD.

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Crossref · 10.1016/j.neulet.2009.11.033

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Authors
Padurariu, M., Ciobica, A., Hritcu, L., Stoica, B., Bild, W., & Stefanescu, C.
Affiliations
  • Alexandru Ioan Cuza University (RO)
  • Grigore T. Popa University of Medicine and Pharmacy (RO)
Corresponding author
Ciobica, Alin
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2010-01
Volume
469
Issue
1
Pages
6-10
ISSN
0304-3940 (ISSN-L)
OpenAlex
W2071214407
Cited by
378
References
40
Citations by year
2026: 6 · 2025: 11 · 2024: 20 · 2023: 25 · 2022: 20 · 2021: 34 · 2020: 26 · 2019: 30 · 2018: 25 · 2017: 16 · 2016: 14 · 2015: 25 · 2014: 31 · 2013: 24 · 2012: 33
FWCI
14.18
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
mild cognitive impairment, Alzheimer's disease, oxidative stress, superoxide dismutase, glutathione peroxidase, lipid peroxidation, malondialdehyde, serum biomarkers, antioxidant enzymes, oxidative damage
MeSH terms
Alzheimer Disease, Cognition Disorders, Female, Glutathione Peroxidase, Humans, Male, Malondialdehyde, Middle Aged, Superoxide Dismutase, Biomarkers, Oxidative Stress

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