Cited by 103Advanced Glycation End Products researchDementia and Cognitive Impairment ResearchNutritional Studies and Diet

Nutrition and AGE‐ing: Focusing on Alzheimer’s Disease

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Abate, Giulia, Marziano, Mariagrazia, Rungratanawanich, Wiramon, Memo, Maurizio, Uberti, Daniela·2017·Oxidative Medicine and Cellular Longevity

Abstract

Recently, the role of food and nutrition in preventing or delaying chronic disability in the elderly population has received great attention. Thanks to their ability to influence biochemical and biological processes, bioactive nutrients are considered modifiable factors capable of preserving a healthy brain status. A diet rich in vitamins and polyphenols and poor in saturated fatty acids has been recommended. In the prospective of a healthy diet, cooking methods should be also considered. In fact, cooking procedures can modify the original dietary content, contributing not only to the loss of healthy nutrients, but also to the formation of toxins, including advanced glycation end products (AGEs). These harmful compounds are adsorbed at intestinal levels and can contribute to the ageing process. The accumulation of AGEs in ageing (“AGE‐ing”) is further involved in the exacerbation of neurodegenerative and many other chronic diseases. In this review, we discuss food’s dual role as both source of bioactive nutrients and reservoir for potential toxic compounds—paying particular attention to the importance of proper nutrition in preventing/delaying Alzheimer’s disease. In addition, we focus on the importance of a good education in processing food in order to benefit from the nutritional properties of an optimal diet.

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Crossref · 10.1155/2017/7039816

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  • AGEs contribute to the development and progression of various aging-related pathological conditions, including diabetes, cardiovascular complications, gut microbiome-associated illnesses, liver or neurodegenerative diseases, and cancer.

    “Recent studies in basic and translational research have revealed the contributing roles of AGEs in the development and progression of various aging-related pathological conditions, such as diabetes, cardiovascular complications, gut microbiome-associated illnesses, liver or neurodegenerative diseases, and cancer.”
  • Dietary AGE formation depends on temperature, water content, pH status, and cooking time and method.

    “This formation of dietary AGEs depends on various factors, such as (1) temperature. e.g., the food browning process; (2) water content. e.g., dry-heat cooking; (3) pH status, e.g., food processing at high pH; and (4) cooking time and method, e.g., long-term cooking or storage and frying or broiling.”
  • Exogenous AGEs include dietary AGEs and cigarette smoke.

    “Exogenous AGEs include dietary AGEs (e.g., foods and beverages such as soft drinks containing high fructose corn sirup and/or sugar) and cigarette smoke.”
  • Cross-links formed by interactions of AGEs with RAGEs have been found during the development and progression of various aging-related diseases.

    “Cross-links formed by the interactions of AGEs with their cell surface receptors for advanced glycation end products (RAGEs) have been found during the development and progression of various aging-related diseases, such as diabetes, cardiovascular complications, kidney malfunctions, osteoporosis, cancer, neurodegenerative diseases, and liver disorders4,5”

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Research works printed but not linked: 1

  1. [43]Eagappan K. Sasikumar S. Functional nutrition is a deterimental factor in biological aging International Journal of Pharmaceutical Sciences Review and Research 2015 32 1, article 27 153 161 2-s2.0-84930028581

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Authors
Abate, G., Marziano, M., Rungratanawanich, W., Memo, M., & Uberti, D.
Affiliations
University of Brescia (IT)
Corresponding author
Uberti, Daniela
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2017-01
Volume
2017
Issue
1
Pages
7039816-7039816
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
OpenAlex
W2576784305
Cited by
103
References
107
Citations by year
2026: 1 · 2025: 9 · 2024: 9 · 2023: 10 · 2022: 10 · 2021: 11 · 2020: 12 · 2019: 17 · 2018: 18 · 2017: 6
FWCI
1.89
Type
journal article
Language
en
Open access
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, public-domain)
Funders
Ministry of University and Research (PAN LAB PON A3_00166)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
Alzheimer's disease, aging, advanced glycation end products, bioactive nutrients, polyphenols, vitamins, saturated fatty acids, cooking methods, food processing, neurodegeneration, dietary toxins, brain health, older adults
MeSH terms
Aged, Alzheimer Disease, Diet, Humans, Nutritional Status, Glycation End Products, Advanced, Disease Progression

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