Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice

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Amyloid neuropathology in the single Arctic APP transgenic model affects interconnected brain regions

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Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging

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Impaired β-Amyloid Secretion in Alzheimer's Disease Pathogenesis

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Soluble oligomeric forms of beta-amyloid (Aβ) peptide stimulate Aβ production via astrogliosis in the rat brain

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Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer’s Disease

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Independent Effects of Intra- and Extracellular Aβ on Learning-Related Gene Expression

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Critical role of intraneuronal Aβ in Alzheimer's disease: Technical challenges in studying intracellular Aβ

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Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology

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Familial Alzheimer’s disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system

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Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multiparametric imaging

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Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

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Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer’s disease

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Early Enriched Environment Exposure Protects Spatial Memory and Accelerates Amyloid Plaque Formation in APPSwe/PS1L166P Mice

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Hyperhomocysteinemia in Alzheimer's Disease: The Hen and the Egg?

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Neurofibrillary Tangles of Aβx-40 in Alzheimer’s Disease Brains

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Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus

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Aquaporin 4 is differentially increased and dislocated in association with tau and amyloid-beta

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Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

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Involvement of GluN2B subunit containing N-methyl- d -aspartate (NMDA) receptors in mediating the acute and chronic synaptotoxic effects of oligomeric amyloid-beta (Aβ) in murine models of Alzheimer's disease (AD)

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The Effects of Endogenous Non-Peptide Molecule Isatin and Hydrogen Peroxide on Proteomic Profiling of Rat Brain Amyloid-β Binding Proteins: Relevance to Alzheimer’s Disease?

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Reelin-mediated Signaling during Normal and Pathological Forms of Aging.

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High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils

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fMRI Reveals Mitigation of Cerebrovascular Dysfunction by Bradykinin Receptors 1 and 2 Inhibitor Noscapine in a Mouse Model of Cerebral Amyloidosis

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The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model

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Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer’s disease

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Cognitive Decline and Modulation of Alzheimer’s Disease-Related Genes After Inhibition of MicroRNA-101 in Mouse Hippocampal Neurons

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Analyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer’s Disease Pathology

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The Relevance of Amyloid β-Calmodulin Complexation in Neurons and Brain Degeneration in Alzheimer’s Disease

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Vascular response to acetazolamide decreases as a function of age in the arcAβ mouse model of cerebral amyloidosis

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Non-invasive visualization of amyloid-beta deposits in Alzheimer amyloidosis mice using magnetic resonance imaging and fluorescence molecular tomography

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Enhanced Amyloidogenic Processing of Amyloid Precursor Protein and Cell Death Under Prolonged Endoplasmic Reticulum Stress in Brain Endothelial Cells

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The Pursuit of the “Inside” of the Amyloid Hypothesis—Is C99 a Promising Therapeutic Target for Alzheimer’s Disease?

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Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone

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Abundance of Aβ5-xlike immunoreactivity in transgenic 5XFAD, APP/PS1KI and 3xTG mice, sporadic and familial Alzheimer’s disease

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The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

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Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

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Reconstituted mother tinctures of Gelsemium sempervirens L. improve memory and cognitive impairment in mice scopolamine-induced dementia model

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Recent advances in distal myopathy with rimmed vacuoles (DMRV) or hIBM: treatment perspectives

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A Bifunctional Anti-Amyloid Blocks Oxidative Stress and the Accumulation of Intraneuronal Amyloid-Beta

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Galanin Protects Against Intracellular Amyloid Toxicity in Human Primary Neurons

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Intraneuronal Aβ Accumulation, Amyloid Plaques, and Synapse Pathology in Alzheimer’s Disease

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Active vaccination with ankyrin G reduces β-amyloid pathology in APP transgenic mice

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RAGE Does Not Affect Amyloid Pathology in Transgenic ArcAβ Mice

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Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-β

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Amyloid-β: A potential mediator of aging-related vascular pathologies

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Genetic Animal Models of Cerebral Vasculopathies

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Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease

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CHF 5074 restores visual memory ability and pre‐synaptic cortical acetylcholine release in pre‐plaque Tg2576 mice

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Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model

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GABA-A receptor modulating steroids in acute and chronic stress; relevance for cognition and dementia?

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C1q, a small molecule with high impact on brain development: putative role for aging processes and the occurrence of Alzheimer’s disease

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Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice

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Induced Pluripotent Stem Cells Derived from Alzheimer’s Disease Patients: The Promise, the Hope and the Path Ahead

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Potential Therapeutic Implications of Gelsolin in Alzheimer's Disease

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In Vivo Two Photon Imaging of Astrocytic Structure and Function in Alzheimer’s Disease

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Yeast Model of Amyloid-β and Tau Aggregation in Alzheimer’s Disease

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Contribution of early Alzheimer's disease‐related pathophysiology to the development of acquired epilepsy

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HSP110 is a modulator of amyloid beta (Aβ) aggregation and proteotoxicity

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Chronic administration of XBD173 ameliorates cognitive deficits and neuropathology via 18 kDa translocator protein (TSPO) in a mouse model of Alzheimer’s disease

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Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo : A Microdialysis Study

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Cell surface proteoglycan-mediated uptake and accumulation of the Alzheimer's disease peptide Aβ(1–42)

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Probing differences among Aβ oligomers with two triangular trimers derived from Aβ

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Aβ Peptide Fibrillar Architectures Controlled by Conformational Constraints of the Monomer

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Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA

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Magnetic Resonance Q Mapping Reveals a Decrease in Microvessel Density in the arcAβ Mouse Model of Cerebral Amyloidosis

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Whole brain optoacoustic tomography reveals strain-specific regional beta-amyloid densities in Alzheimer’s disease amyloidosis modelsPreprint

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Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component

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Endosomal trafficking and related genetic underpinnings as a hub in Alzheimer's disease

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Lowering levels of reelin in entorhinal cortex layer II-neurons results in lowered levels of intracellular amyloid-β

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Octodon degus: a strong attractor for Alzheimer research.

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Localization of mature neprilysin in lipid rafts

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An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

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Detection and quantification of Aβ−3–40 (APP669‐711) in cerebrospinal fluid

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Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease

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Efficient characterization of multiple binding sites of small molecule imaging ligands on amyloid-beta, tau and alpha-synuclein

Sobek, J., Li, J., Combes, B. F., Gerez, J., Nilsson, K. P. R., Henrich, M. T., Geibl, F. F., Shi, K., Rominger, A., Oertel, W. H., et al. (2024) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-024-06806-7 · Cited by 14

Critical thinking of Alzheimer’s transgenic mouse model: current research and future perspective

Li, X., Quan, M., Wei, Y., Wang, W., Xu, L., Wang, Q., & Jia, J. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2357-x · Cited by 14

Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus

Forner, S., Martini, A. C., Prieto, G. A., Dang, C. T., Rodríguez‐Ortiz, C. J., Reyes‐Ruiz, J. M., Trujillo‐Estrada, L., da Cunha, C., Andrews, E. J., Phan, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52324-0 · Cited by 15

Evidence for the accumulation of Abeta immunoreactive material in the human brain and in transgenic animal models

Cuello, A. C., Allard, S., & Ferretti, M. T. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.05.020 · Cited by 15

Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation

Song, X., Zhou, H.-Y., Sun, Y., & Huang, H. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05305-w · Cited by 13

Virtual histology of Alzheimer’s disease: Biometal entrapment within amyloid- β plaques allows for detection via X-ray phase-contrast imaging

Chourrout, M., Sandt, C., Weitkamp, T., Dučić, T., Meyronet, D., Baron, T., Klohs, J., Rama, N., Boutin, H., Singh, S., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.07.046 · Cited by 12

Phosphorylation-state dependent intraneuronal sorting of Aβ differentially impairs autophagy and the endo-lysosomal system

Kapadia, A., Theil, S., Opitz, S., Villacampa, N., Beckert, H., Schoch, S., Heneka, M. T., Kumar, S., & Walter, J. (2023) · Autophagy · doi:10.1080/15548627.2023.2252300 · Cited by 13

Cytochrome c peroxidase activity of heme bound amyloid β peptides

Seal, M., Ghosh, C., Basu, O., & Dey, S. G. (2016) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-016-1367-6 · Cited by 12

Loss of lysosomal acid lipase contributes to Alzheimer's disease pathology and cognitive decline

Barnett, A. M., McNair, E. M., Dawkins, L., Zou, J., Nikolova, V. D., Moy, S. S., Sutherland, G. T., Stevens, J., Colie, M., Katemboh, K., et al. (2025) · Alzheimer's & Dementia · doi:10.1002/alz.70486 · Cited by 12

Altered sleep behavior strengthens face validity in the ArcAβ mouse model for Alzheimer’s disease

Altunkaya, A., Deichsel, C., Kreuzer, M., Nguyen, D.-M., Wintergerst, A.-M., Rammes, G., Schneider, G. H., & Fenzl, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-51560-3 · Cited by 11

Amyloid-Binding Proteins: Affinity-Based Separation, Proteomic Identification, and Optical Biosensor Validation

Medvedev, A. E., Бунеева, О. А., Kopylov, A. T., Gnedenko, O. V., Ivanov, A. S., Zgoda, V. G., & Makarov, A. А. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2550-6_33 · Cited by 11

Two structurally defined Aβ polymorphs promote different pathological changes in susceptible mice

Gomez‐Gutierrez, R., Ghosh, U., Yau, W., Gamez, N., Do, K., Kramm, C., Shirani, H., Vegas‐Gomez, L., Schulz, J., Moreno‐González, I., et al. (2023) · EMBO Reports · doi:10.15252/embr.202357003 · Cited by 12

Molecular sabotage of hippocampal synaptic plasticity by amyloid-β in Alzheimer's disease: A narrative review

Behroozi, Z., Askarpour, H., & Baghcheghi, Y. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261415807 · Cited by 10

Models of cerebral amyloid angiopathy-related intracerebral hemorrhage

Vargas-George, S. A., & Dave, K. R. (2022) · Brain Hemorrhages · doi:10.1016/j.hest.2022.05.001 · Cited by 10

Design and Experimental Evaluation of a Peptide Antagonist against Amyloid β(1–42) Interactions with Calmodulin and Calbindin-D28k

Salazar, J., Poejo, J., Mata, A. M., Samhan-Arias, A. K., & Gutiérrez‐Merino, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042289 · Cited by 10

N-Methyl-D-Aspartate Receptors Mediate Synaptic Plasticity Impairment of Hippocampal Neurons Due to Arsenic Exposure

Liu, X., & Wang, J. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.07.017 · Cited by 10

Изомеризация остатка Asp7 усиливает токсическое действие бета-амилоида и его фосфорилированной формы на клетки нейробластомы SH-SY5Y

Barykin, E. P., Петрушанко, И. Ю., Burnysheva, K. M., Makarov, A. А., & Mitkevich, V. A. (2016) · Molecular Biology · doi:10.7868/s0026898416050037 · Cited by 10

Isomerization of Asp7 increases the toxic effects of amyloid β and its phosphorylated form in SH-SY5Y neuroblastoma cells

Barykin, E. P., Petrushanko, I. Y., Burnysheva, K. M., Makarov, A. А., & Mitkevich, V. A. (2016) · Molecular Biology · doi:10.1134/s0026893316050034 · Cited by 10

Transcranial in vivo detection of amyloid-beta at single plaque resolution with large-field multifocal illumination fluorescence microscopyPreprint

Ni, R., Chen, Z., Shi, G., Villois, A., Zhou, Q., Arosio, P., Nitsch, R. M., Nilsson, K. P. R., Klohs, J., & Razansky, D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.01.929844 · Cited by 10

A Combination of Heavy Metals and Intracellular Pathway Modulators Induces Alzheimer Disease-like Pathologies in Organotypic Brain Slices

Korde, D. S., & Humpel, C. (2024) · Biomolecules · doi:10.3390/biom14020165 · Cited by 9

Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models

Thomason, L. A. M., Stefanovic, B., & McLaurin, J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12181 · Cited by 9

Role of Membrane Tension Sensitive Endocytosis and Rho GTPases in the Uptake of the Alzheimer’s Disease Peptide Aβ(1-42)

Wesén, E. V., Lundmark, R., & Esbjörner, E. K. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00053 · Cited by 9

The effects of green tea on cognitive impairments in the rat model of Alzheimer’s disease: protection against inflammatory and oxidative damage

Amirpour, M., Mirshekar, M. A., Sedaghat, G., Montazerifar, F., Shourestani, S., Arabmoazzen, S., & Naghizadeh, M. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2021.2003946 · Cited by 9

Characterization of microtubule-associated protein tau isoforms and Alzheimer’s disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer’s disease

Davies, E. S., Morphew, R. M., Cutress, D. J., Morton, A. J., & McBride, S. D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04572-z · Cited by 9

Towards a Cure for Dementia: The Role of Axonal Transport in Alzheimer's Disease

Wilson, R. J. (2008) · Science Progress · doi:10.3184/003685008x285375 · Cited by 9

Independent Effects of Intra- and Extracellular Aβ on Learning-Related Gene Expression

Wegenast‐Braun, B. M., Maisch, A. F., Eicke, D., Radde, R., Herzig, M. C., Staufenbiel, M., Jucker, M., & Calhoun, M. E. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090044 · Cited by 40

The Arctic Alzheimer mutation facilitates early intraneuronal Aβ aggregation and senile plaque formation in transgenic mice

Lord, A., Kalimo, H., Eckman, C., Zhang, X.-Q., Lannfelt, L., & Nilsson, L. N. G. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.007 · Cited by 260

S3‐03‐03: Functional correlations of intracellular Aβ peptide in transgenic mouse models

Delatour, B., Ly, M., & Duyckaerts, C. J. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.2371

P1–120: Small arctic Aβ aggregates disturb synaptic plasticity and behavior in transgenic mice

Knobloch, M., Farinelli, M., Konietzko, U., Mansuy, I. M., & Nitsch, R. M. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.496

Arctic Aβ selectively increases diffuse deposition of wild type Aβ in APP transgenic mice with the Swedish mutation

Lord, A., Philipson, O., Klingstedt, T., Nilsson, K. P. R., Hammarström, P., Lannfelt, L., & Nilsson, L. N. G. (2010)