Cited by 259Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice

Knobloch, Marlen, Konietzko, Uwe, Krebs, Danielle C., Nitsch, Roger M.·2007·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2006.06.019

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Abstract

The brain pathology of Alzheimer's disease is characterized by abnormally aggregated Abeta in extracellular beta-amyloid plaques and along blood vessel walls, but the relation to intracellular Abeta remains unclear. To address the role of intracellular Abeta deposition in vivo, we expressed human APP with the combined Swedish and Arctic mutations in mice (arcAbeta mice). Intracellular punctate deposits of Abeta occurred concomitantly with robust cognitive impairments at the age of 6 months before the onset of beta-amyloid plaque formation and cerebral beta-amyloid angiopathy. beta-Amyloid plaques from arcAbeta mice had distinct dense-core morphologies with blood vessels appearing as seeding origins, suggesting reduced clearance of Abeta across blood vessels in arcAbeta mice. The co-incidence of intracellular Abeta deposits with behavioral deficits support an early role of intracellular Abeta in the pathophysiological cascade leading to beta-amyloid formation and functional impairment.

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Authors: Knobloch, M., Konietzko, U., Krebs, D. C., & Nitsch, R. M.
Affiliations: University of Zurich (CH)
Corresponding author: Nitsch, Roger M.
ORCID: Knobloch, Marlen
Konietzko, Uwe
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2007-09
Volume: 28
Issue: 9
Pages: 1297-1306
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2006.06.019
OpenAlex: W2006696380
Cited by: 259
References: 38
Citations by year: 2026: 4 · 2025: 8 · 2024: 15 · 2023: 15 · 2022: 17 · 2021: 10 · 2020: 11 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 20 · 2015: 15 · 2014: 12 · 2013: 11 · 2012: 17
FWCI: 7.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (3200B0-112616)
European Commission (6027, LSHM-CT-2003-503330)
nccr – on the move
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, APP transgenic mice, cognitive impairment, amyloid plaques, cerebral amyloid angiopathy, amyloid clearance, amyloid seeding, APP mutations
MeSH terms: Age Factors, Analysis of Variance, Animals, Avoidance Learning, Behavior, Animal, Cognition Disorders, Exploratory Behavior, Humans, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Mutation, Neurologic Examination, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Maze Learning, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Rotarod Performance Test, Mice, Plaque, Amyloid

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Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice

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