Neurofibrillary changes of the Alzheimer type in very elderly individuals: Neither inevitable nor benign
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
NFTs are also very common in certain brainstem nuclei in subjects without dementia.
“Recently, it has been reported that NFTs are also very common in certain brainstem nuclei in subjects without dementia (39-44).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [40]
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Self-citationCurrent concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781 · see citing works
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 3,920 · see citing works
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
Self-citationNeurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357 · see citing works
Self-citationFrequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works
Self-citationHYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works
Neuropathology of Cognitively Normal Elderly
Knopman, D. S., Parisi, J. E., Salviati, A., Floriach-Robert, M., Boeve, B. F., Ivnik, R. J., Smith, G. E., Dickson, D. W., Johnson, K. A., Petersen, L. E., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.11.1087 · Cited by 674 · see citing works
Self-citationAlzheimer neuropathologic alterations in aged cognitively normal subjects
Davis, D. G., Schmitt, F. A., Wekstein, D. R., & Markesbery, W. R. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199904000-00008 · Cited by 516 · see citing works
Braak, H., & Braak, E. (1996) · Acta Neuropathologica · doi:10.1007/s004010050508 · Cited by 406 · see citing works
Self-citationRiley, K. P., Snowdon, D. A., & Markesbery, W. R. (2002) · Annals of Neurology · doi:10.1002/ana.10161 · Cited by 392 · see citing works
A Systems Level Analysis of Transcriptional Changes in Alzheimer's Disease and Normal Aging
Miller, J. A., Oldham, M. C., & Geschwind, D. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4098-07.2008 · Cited by 385 · see citing works
Neurons May Live for Decades with Neurofibrillary Tangles
Morsch, R., Simon, W., & Coleman, P. D. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199902000-00008 · Cited by 370 · see citing works
A focus on the synapse for neuroprotection in Alzheimer disease and other dementias
Coleman, P., Federoff, H., & Kurlan, R. (2004) · Neurology · doi:10.1212/01.wnl.0000140626.48118.0a · Cited by 314 · see citing works
Memory and mental status correlates of modified Braak staging
Grober, E. H., Dickson, D. W., Sliwinski, M. J., Herman Buschke, L., Katz, M., Crystal, H., & Lipton, R. B. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00063-9 · Cited by 235 · see citing works
The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms☆
Finch, C. E., & Sapolsky, R. M. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00053-6 · Cited by 204 · see citing works
Reisberg, ., Franssen, E., Hasan, S. M., Monteiro, I., Boksay, I., Souren, L. E. M., Kenowsky, S., Auer, S., Elahi, S., & Kluger, A. (1999) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/pl00014170 · Cited by 195 · see citing works
Early-life risk factors and the development of Alzheimer’s disease
Moceri, V. M., Kukull, W. A., Emanuel, I., van Belle, G., & Larson, E. B. (2000) · Neurology · doi:10.1212/wnl.54.2.415 · Cited by 184 · see citing works
Mild Cognitive Impairment Is Early-Stage Alzheimer Disease
Morris, J. C. (2006) · Archives of Neurology · doi:10.1001/archneur.63.1.15 · Cited by 157 · see citing works
Green, M. S., Kaye, J. A., & Ball, M. J. (2000) · Neurology · doi:10.1212/wnl.54.1.105 · Cited by 153 · see citing works
Neurodegeneration in Normal Brain Aging and Disease
Thal, D. R., Del Tredici, K., & Braak, H. (2004) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2004.23.pe26 · Cited by 149 · see citing works
Self-citationIs aging part of Alzheimer's disease, or is Alzheimer's disease part of aging?
Swerdlow, R. H. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.021 · Cited by 144 · see citing works
Clinical validity of Braak neuropathological staging in the oldest-old
Gold, G., Bouras, C., Kövari, E., Canuto, A., González Glaría, B., Malky, A., Hof, P. R., Michel, J.-P., & Giannakopoulos, P. (2000) · Acta Neuropathologica · doi:10.1007/s004010051163 · Cited by 128 · see citing works
Arendt, T., Brückner, M. K., Gertz, H.-J., & Marcova, L. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00509-5 · Cited by 122 · see citing works
Integrated phylogeny of the primate brain, with special reference to humans and their diseases
Rapoport, S. I. (1990) · Brain Research Reviews · doi:10.1016/0165-0173(90)90004-8 · Cited by 108 · see citing works
Neuropathological background of twenty-seven centenarian brains
Mizutani, T., & Shimada, H. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90047-o · Cited by 106 · see citing works
Robine, J., & Allard, M. (1998) · Science · doi:10.1126/science.279.5358.1831h · Cited by 105 · see citing works
Hyman, B. T., & Gómez‐Isla, T. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90031-0 · Cited by 76 · see citing works
Developmental origins of aging in brain and blood vessels: an overview
Finch, C. E. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.03.015 · Cited by 69 · see citing works
Mild Cognitive Impairment. Aging to Alzheimer's disease
Jellinger, K. A. (2003) · European Journal of Neurology · doi:10.1046/j.1468-1331.2003.00603_3.x · Cited by 61 · see citing works
Brain evolution and Alzheimer's disease.
Рапопорт, С. И. (1988) · PubMed · Cited by 59 · see citing works
Alzheimer: 100 Years and Beyond
Jucker, M., Beyreuther, K. T., Haass, C., Nitsch, R. M., & Christen, Y. (2006) · Springer eBooks · doi:10.1007/978-3-540-37652-1 · Cited by 50 · see citing works
Mental Status Examination of an Exceptional Case of Longevity
Ritchie, K. A. (1995) · The British Journal of Psychiatry · doi:10.1192/bjp.166.2.229 · Cited by 41 · see citing works
Callahan, L. M., Selski, D. J., Martzen, M. R., Cheetham, J., & Coleman, P. D. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90041-8 · Cited by 38 · see citing works
Petersen, R. C. (2003) · doi:10.1093/oso/9780195123425.003.0001 · Cited by 31 · see citing works
Senile Dementia of Extreme Aging: A Common Disorder of Centenarians
Powell, A. L. (1994) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106704 · Cited by 26 · see citing works
Validated Worldwide Supercentenarians, Living and Recently Deceased
Young, R. D., & Coles, L. S. (2011) · Rejuvenation Research · doi:10.1089/rej.2011.1159 · Cited by 20 · see citing works
Clinical validity of Braak staging in the oldest-old
Jellinger, K. A. (2000) · Acta Neuropathologica · doi:10.1007/s004010051164 · Cited by 16 · see citing works
The Biology of Aging in Model Organisms
Finch, C. E. (2003) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200304002-00002 · Cited by 14 · see citing works
Validated Worldwide Supercentenarians, Living and Recently Deceased
Coles, L. S. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0695 · Cited by 13 · see citing works
Braak, H., Tredici, K. D., & Braak, E. (2003) · doi:10.1093/oso/9780195123425.003.0008 · Cited by 5 · see citing works
Self-citationNeuropathological Changes in Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease
Gómez‐Isla, T., & Hyman, B. T. (2003) · doi:10.1093/oso/9780195123425.003.0009 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318232a379 · Cited by 2,194 · see citing works
“Thus, advanced age per se is not a precondition for the formation of the ADassociated tau lesions; rather, there is now strong evidence that the pathologic process underlying AD is not ‘‘age-dependent’’ but an uncommonly slowly progressive one that frequently extends into old age (55).”
BackgroundSelf-citationNelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · see citing works
Self-citationWhen does age-related cognitive decline begin?
Salthouse, T. A. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.09.023 · Cited by 1,848 · see citing works
“…1999; Salat et al., 2004), serotonin receptor binding (Sheline et al., 2002), striatal dopamine binding (Erixon-Lindroth et al., 2005; Volkow et al., 2000), accumulation of neurofibrillary tangles (Del Tredici and Braak, 2008), and concentrations of various brain metabolites (Kadota et al., 2001).”
BackgroundThe pathological process underlying Alzheimer’s disease in individuals under thirty
Braak, H., & Del Tredici, K. (2011) · Acta Neuropathologica · doi:10.1007/s00401-010-0789-4 · Cited by 812 · see citing works
Self-citationNeuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship
Nelson, P. T., Braak, H., & Markesbery, W. R. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181919a48 · Cited by 643 · see citing works
Self-citationDaulatzai, M. A. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23777 · Cited by 433 · see citing works
Nelson, P. T., Head, E., Schmitt, F. A., Davis, P. R., Neltner, J. H., Jicha, G. A., Abner, E. L., Smith, C. D., Van Eldik, L. J., Kryscio, R. J., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0826-y · Cited by 365 · see citing works
“The chart (b) is a subjective amalgamation of multiple published studies pertinent to this important topic [19, 21, 61, 76, 79, 80, 96, 102, 105, 106, 115, 140, 145, 150, 156, 158, 171, 176, 184, 193, 198, 211, 217, 228, 231] 580 Acta Neuropathol (2011) 121:571–587”
“New Old Pathologies”: AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS)
Nelson, P. T., Trojanowski, J. Q., Abner, E. L., Al-Janabi, O. M., Jicha, G. A., Schmitt, F. A., Smith, C. D., Fardo, D. W., Wang, W.-X., Kryscio, R. J., et al. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw033 · Cited by 158 · see citing works
Accelerated cognitive aging following severe traumatic brain injury: A review
Wood, R. L. (2017) · Brain Injury · doi:10.1080/02699052.2017.1332387 · Cited by 59 · see citing works
Long-term episodic memory decline is associated with olfactory deficits only in carriers of ApoE-є4
Olofsson, J., Josefsson, M., Ekström, I., Wilson, D. A., Nyberg, L. H., Nordin, S., Adolfsson, A. N., Adolfsson, R., Nilsson, L., & Larsson, M. U. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.03.004 · Cited by 53 · see citing works
http://www.frontiersin.org/neuroscience/agingneuroscience/paper/10.3389/fnagi.2010.00024/
Hedner, M. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00024 · Cited by 33 · see citing works
“Since sub-clinical levels of AD-related neuropathology is probably present in a majority of elderly individuals (del Tredici and Braak, 2008), and since the disorder affects olfactory function also in preclinical stages (Bacon et al., 1998; Tabert et al., 2005; Olofsson et al., 2010), effects of…”
Intensity discrimination deficits cause habituation changes in middle-aged Caenorhabditis elegans.
Timbers, T., Giles, A., Ardiel, E. L., Kerr, R., & Rankin, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.03.016 · Cited by 32 · see citing works
Centenarians as Models of Resistance and Resilience to Alzheimer’s Disease and Related Dementias
Andersen, S. L. (2020) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20200018 · Cited by 31 · see citing works
What’s my age again? Age categories as interactive kinds
Maung, H. H. (2021) · History & Philosophy of the Life Sciences · doi:10.1007/s40656-021-00388-5 · Cited by 25 · see citing works
MicroRNA in situ hybridization in the human entorhinal and transentorhinal cortex
Nelson, P. T. (2010) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.007.2010 · Cited by 24 · see citing works
Rajesh, V., & Ilanthalir, S. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1965-2 · Cited by 23 · see citing works
Neill, D. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.06.004 · Cited by 21 · see citing works
Alghadir, A. H., Gabr, S. A., Al-Momani, M. O., & Almomani, F. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155373 · Cited by 20 · see citing works
Daulatzai, M. A. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9528-x · Cited by 12 · see citing works
Braak, H., & Tredici, K. D. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374105-9.00269-0 · Cited by 10 · see citing works
Self-citationAgeing in the Seventeenth and Eighteenth Centuries
Carvallo, S. (2010) · Science in Context · doi:10.1017/s0269889710000086 · Cited by 6 · see citing works
“However, he made a radical distinction between a sane old age – which he does not define positively – and the associated pathologies, just as one must distinguish a sane body from a sick body.4 Thus, those discussions contravene the Hippocratic aphorism 4 This question is still open: two recent studies prove the possi…”
BackgroundSani, N. F. A., Hamzah, A. I. Z. A., Bakar, Z. H. A., Yusof, Y. A. M., Makpol, S., Ngah, W. Z. W., & Damanhuri, H. A. (2021) · Cells · doi:10.3390/cells10071611 · Cited by 4 · see citing works
“Some evidence reported that cognitive decline in healthy individuals might occur beginning from the late 20s, based on the regional brain Cells 2021, 10, 1611. https://doi.org/10.3390/cells10071611 https://www.mdpi.com/journal/cells Cells 2021, 10, 1611 2 of 25 volume [8,9], myelin integrity [10,11], accumulation of N…”
BackgroundInfluentialOdor identification in aging and dementia : Influences of cognition and the ApoE gene
Olofsson, J. (2008) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 4 · see citing works
Almudhi, A., & Gabr, S. A. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103580 · Cited by 1 · see citing works
“…were significantly described in varioussubjects of cognitive disabilities (Pieperhoff et al., 2008; Fotenos et al., 2005; Guh et al., 2009; Li et al., 2009; Hsu et al., 2008; Salat et al., 2004; Del Tredici and Braak, 2008; Sheline et al., 2002; Erixon-Lindroth et al., 2005; Volkow et al., 2000).”
BackgroundZou, W. (2023) · Springer eBooks · doi:10.1007/978-3-031-20565-1_4 · Cited by 1 · see citing works
Prinsloo, H. B., & Claassen, J. (2013) · Journal of the Southern African Institute of Mining and Metallurgy
Volumetric assessment of hippocampus and cerebral white matter lesions in structural MRI
Olsson, E. (2013) · Gothenburg University Publications Electronic Archive (Gothenburg University)
- Authors
- Del Tredici, K., & Braak, H.
- Corresponding author
- Braak, Heiko
- ORCID
- Braak, Heiko
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 29
- Issue
- 8
- Pages
- 1133-1136
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2012032805
- Cited by
- 27
- References
- 44
- Citations by year
- 2023: 2 · 2021: 2 · 2020: 2 · 2017: 1 · 2016: 4 · 2015: 1 · 2013: 2 · 2012: 2
- FWCI
- 2.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurofibrillary tangles, oldest old, cognitive impairment, aerobic exercise, cortisol, inflammatory cytokines, interleukin-6, TNF-α, C-reactive protein, adiposity, older adults, neuroprotection, anti-inflammatory activity, hippocampal structure, HbA1c, body mass index, waist-to-hip ratio
- MeSH terms
- Aged, 80 and over, Brain, Brain Diseases, Humans, Frail Elderly, Disease-Free Survival, Neurodegenerative Diseases, Atherosclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
