Cited by 406Alzheimer's disease research and treatmentsNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

Braak, H., Braak, E.·1996·Acta Neuropathologica

Abstract

The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.

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Crossref · 10.1007/s004010050508

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22 of 22 references verified0 citation errors · 0 not checkable

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  • Previous classical neuropathological observations report a conspicuous temporal relationship with CNS myelination, which occurs latest in those brain regions that are the first to develop AD pathology.

    “Our working model is further supported by previous classical neuropathological observations55, in which a conspicuous temporal relationship with CNS myelination was reported, which occurs latest in those brain regions that are the first to develop AD pathology.”

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Authors
Braak, H., & Braak, E.
Affiliations
Goethe University Frankfurt (DE)
Venue
Acta Neuropathologica
Published
1996-07-15
Volume
92
Issue
2
Pages
197-201
ISSN
  • 0001-6322 (ISSN-L)
  • 1432-0533
OpenAlex
W2025693096
Cited by
406
References
22
Citations by year
2026: 12 · 2025: 13 · 2024: 16 · 2023: 29 · 2022: 15 · 2021: 18 · 2020: 15 · 2019: 15 · 2018: 20 · 2017: 14 · 2016: 8 · 2015: 21 · 2014: 13 · 2013: 28 · 2012: 19
FWCI
4.85
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Neuropathologica (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Bundesministerium für Forschung und Technologie
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, neurofibrillary tangles, oligodendrocytes, myelination, neocortex, neuronal cytoskeleton, neurite outgrowth
MeSH terms
Alzheimer Disease, Cerebral Cortex, Humans, Myelin Sheath, Phylogeny, Neurofibrillary Tangles

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