Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis
Abstract
The pattern of neurofibrillary changes which gradually develops in the course of Alzheimer's disease bears a striking resemblance to the inverse sequence of cortical myelination. Factors released by oligodendrocytes exert a strong influence upon nerve cells and suppress disordered neuritic outgrowth. It is suggested that the lack of such factors due to premature dysfunction of oligodendrocytes leads to alterations of the neuronal cytoskeleton and eventually to the appearance of Alzheimer-type neurofibrillary changes.
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Previous classical neuropathological observations report a conspicuous temporal relationship with CNS myelination, which occurs latest in those brain regions that are the first to develop AD pathology.
“Our working model is further supported by previous classical neuropathological observations55, in which a conspicuous temporal relationship with CNS myelination was reported, which occurs latest in those brain regions that are the first to develop AD pathology.”
From Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease (2023) · cites this paper as [55]
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- Authors
- Braak, H., & Braak, E.
- Affiliations
- Goethe University Frankfurt (DE)
- ORCID
- Braak, H.
- Venue
- Acta Neuropathologica
- Published
- 1996-07-15
- Volume
- 92
- Issue
- 2
- Pages
- 197-201
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2025693096
- Cited by
- 406
- References
- 22
- Citations by year
- 2026: 12 · 2025: 13 · 2024: 16 · 2023: 29 · 2022: 15 · 2021: 18 · 2020: 15 · 2019: 15 · 2018: 20 · 2017: 14 · 2016: 8 · 2015: 21 · 2014: 13 · 2013: 28 · 2012: 19
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Forschung und Technologie
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurofibrillary tangles, oligodendrocytes, myelination, neocortex, neuronal cytoskeleton, neurite outgrowth
- MeSH terms
- Alzheimer Disease, Cerebral Cortex, Humans, Myelin Sheath, Phylogeny, Neurofibrillary Tangles
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