Cited by 26Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAdvanced Neuroimaging Techniques and Applications

Cortical Thickness and Microstructural White Matter Changes Detect Amnestic Mild Cognitive Impairment

Wang, Zan, Dai, Zhengjia, Shu, Hao, Liu, Duan, Guo, Qihao, He, Yong, Zhang, Zhijun·2017·Journal of Alzheimer’s Disease

Abstract

Both the apolipoprotein E (APOE) ɛ4 allele and amnestic mild cognitive impairment (aMCI) are considered to be risk factors for Alzheimer’s disease (AD). The primary aim of this study was to determine whether the aMCI-related abnormality in gray matter (GM) cortical thickness and white matter (WM) tracts integrity would be modified by the APOE genotype. A total of 146 older adults, including 64 aMCI patients (28 ɛ4 carriers and 36 non-carriers) and 82 healthy controls (39 ɛ4 carriers and 43 non-carriers), underwent a standardized clinical interview, neuropsychological battery assessment, and multi-modal brain magnetic resonance imaging scans. Compared with control subjects, the patients with aMCI showed significantly reduced cortical thickness bilaterally in the parahippocampal gyrus and disrupted WM integrity in the limbic tracts (e.g., increased mean diffusivity in the right parahippocampal cingulum and bilateral uncinate fasciculus). However, no significant main effects of the APOE genotype and diagnosis-by-genotype interaction on GM thickness and WM integrity were observed. Further, diffusivity measures of the limbic WM tracts were significantly correlated with the parahippocampal atrophy in aMCI. Importantly, the parahippocampal thickness and diffusivity measures of the limbic WM tracts were significantly correlated with the cognitive performance (i.e., episodic memory Z score) in patients with aMCI. These results demonstrate that WM microstructural disruptions in the limbic tracts are present at the early stage of AD in an APOE-independent manner; and this degeneration may occur progressively, in parallel with parahippocampal atrophy, and may specifically contribute to early initial impairment in episodic memory.

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Crossref · 10.3233/jad-160724

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  • Limited evidence suggests that APOE4 may drive accelerated hippocampal atrophy and network disruption with MCI, though others report no modifying effect of APOE4 on WM microstructure in MCI.

    “limited evidence suggests that APOE4 may drive accelerated hippocampal atrophy and network disruption with MCI [22], though others report no modifying effect of APOE4 on WM microstructure in MCI [23].”

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Authors
Wang, Z., Dai, Z., Shu, H., Liu, D., Guo, Q., He, Y., & Zhang, Z.
Affiliations
  • Zhongda Hospital Southeast University (CN)
  • Sun Yat-sen University (CN)
  • Fudan University (CN)
  • State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China
Corresponding author
Zhang, Zhijun
Venue
Journal of Alzheimer’s Disease
Published
2016-11-29
Volume
56
Issue
1
Pages
415-428
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2559739875
Cited by
26
References
85
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 2
FWCI
2.96
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
amnestic mild cognitive impairment, APOE ε4
MeSH terms
Aged, Aged, 80 and over, Apolipoproteins E, Atrophy, Cerebral Cortex, Female, Genotype, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, ROC Curve, Statistics, Nonparametric, Diffusion Magnetic Resonance Imaging, Cognitive Dysfunction, White Matter

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