Cited by 149Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsMicrotubule and mitosis dynamics

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Dynamic association of tau with neuronal membranes is regulated by phosphorylation

Pooler, Amy M., Usardi, Alessia, Evans, Catherine J., Philpott, Karen L., Noble, Wendy, Hanger, Diane P.·2012·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2011.01.005

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Abstract

Tau is an abundant cytosolic protein which regulates cytoskeletal stability by associating with microtubules in a phosphorylation-dependent manner. We have found a significant proportion of tau is located in the membrane fraction of rat cortical neurons and is dephosphorylated, at least at Tau-1 (Ser199/Ser202), AT8 (Ser199/Ser202/Thr205) and PHF-1 (Ser396/Ser404) epitopes. Inhibition of tau kinases casein kinase 1 (CK1) or glycogen synthase kinase-3 decreased tau phosphorylation and significantly increased amounts of tau in the membrane fraction. Mutation of serine/threonine residues to glutamate to mimic phosphorylation in the N-terminal, but not C-terminal, region of tau prevented its membrane localization in transfected cells, demonstrating that the phosphorylation state of tau directly impacts its localization. Inhibiting CK1 in neurons lacking the tyrosine kinase fyn also induced tau dephosphorylation but did not affect its membrane association. Furthermore, inhibition of CK1 increased binding of neuronal tau to the fyn-SH3 domain. We conclude that trafficking of tau between the cytosol and the neuronal membrane is dynamically regulated by tau phosphorylation through a mechanism dependent on fyn expression.

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Authors: Pooler, A. M., Usardi, A., Evans, C. J., Philpott, K. L., Noble, W., & Hanger, D. P.
Affiliations: King's College London (GB)
GlaxoSmithKline (United Kingdom) (GB)
Corresponding author: Pooler, Amy M.
ORCID: Pooler, Amy M.
Noble, Wendy
Hanger, Diane P.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2012-02
Volume: 33
Issue: 2
Pages: 431.e27-431.e38
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2011.01.005
OpenAlex: W2011813094
Cited by: 148
References: 46
Citations by year: 2026: 2 · 2025: 2 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 15 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 16 · 2016: 10 · 2015: 15 · 2014: 12 · 2013: 16 · 2012: 5
FWCI: 8.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords: tau protein, tau phosphorylation, tau dephosphorylation, casein kinase 1, glycogen synthase kinase-3, Fyn tyrosine kinase, Fyn SH3 domain, cortical neurons, microtubule stabilization
MeSH terms: Animals, Animals, Newborn, Cell Membrane, Cells, Cultured, Neurons, tau Proteins, Rats, Sprague-Dawley, Glycogen Synthase Kinase 3, Casein Kinase I, Rats

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Dynamic association of tau with neuronal membranes is regulated by phosphorylation

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