Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD
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Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally, we show that tau KO mice exhibit deficits in spatial reversal learning. These findings underscore the physiological role for tau at the synapse and identify a behavioral correlate of its role in LTD.
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Tau phosphorylation at S396 plays a key role in the induction and maintenance of hippocampal LTD.
“While phosphorylation at S396 plays a key role in the induction and maintenance of hippocampal LTD [142], mutant tau hyperphosphomimetic Ser/Thr isoforms promotes tau distribution to dendritic spines and impairs synaptic function [143].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [142]
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- Authors
- Regan, P., Piers, T., Yi, J.-H., Kim, D.-H., Huh, S., Park, S. J., Ryu, J. H., Whitcomb, D. J., & Cho, K.
- Affiliations
- University of Bristol (GB)
- Chonnam National University (KR)
- Chonnam National University Hospital (KR)
- Kyung Hee University (KR)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-03-25
- Volume
- 35
- Issue
- 12
- Pages
- 4804-4812
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4389589
- OpenAlex
- W1974596754
- Cited by
- 202
- References
- 59
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 12 · 2023: 18 · 2022: 26 · 2021: 30 · 2020: 18 · 2019: 17 · 2018: 21 · 2017: 15 · 2016: 17 · 2015: 8
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- Wellcome Trust
- Royal Society
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BB/G003963/1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- tau phosphorylation, long-term depression, hippocampus, AMPA receptor internalization, long-term potentiation, synaptic plasticity, spatial reversal learning, tau knockout mice
- MeSH terms
- Animals, Endocytosis, Hippocampus, Male, Phosphorylation, Reversal Learning, Serine, tau Proteins, Long-Term Potentiation, Receptors, AMPA, Mice, Knockout, Long-Term Synaptic Depression, Mice, Rats
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