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Cerebrovascular disease, beta-amyloid, and cognition in aging
Open accessAbstract
The present study evaluated cerebrovascular disease (CVD), β-amyloid (Aβ), and cognition in clinically normal elderly adults. Fifty-four participants underwent magnetic resonance imaging (MRI), Pittsburgh compound B (PIB)-positron emission tomography (PET) imaging, and neuropsychological evaluation. High white matter hyperintensity burden and/or presence of infarct defined CVD status (CVD-: n = 27; CVD+: n = 27). PIB-positron emission tomography ratios of Aβ deposition were extracted using Logan plotting (cerebellar reference). Presence of high levels of Aβ in prespecified regions determined PIB status (PIB-: n = 33; PIB+: n = 21). Executive functioning and episodic memory were measured using composite scales. CVD and Aβ, defined as dichotomous or continuous variables, were unrelated to one another. CVD+ participants showed lower executive functioning (p = 0.001) when compared with CVD- individuals. Neither PIB status nor amount of Aβ affected cognition (ps ≥ 0.45), and there was no statistical interaction between CVD and PIB on either cognitive measure. Within this spectrum of normal aging CVD and Aβ aggregation appear to be independent processes with CVD primarily affecting cognition.
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“the Aβ plaques may be found in 35% of cognitively healthy individuals above the age of 60 [290]”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [290]
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Kritsilis, M., V. Rizou, S., Koutsoudaki, P. N., Evangelou, K., Gorgoulis, V. G., & Papadopoulos, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102937 · Cited by 448
“Interestingly, the Aβ plaques may be found in 35% of cognitively healthy individuals above the age of 60 [290] and the Aβ load, which has been our main target, correlates better with age than disease severity in AD [291–293], casting doubt on the amyloid hypothesis.”
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Vulnerable Neural Systems and the Borderland of Brain Aging and Neurodegeneration
Jagust, W. J. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.002 · Cited by 335
Self-citationVascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly
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Metadata
- Authors
- Marchant, N. L., Reed, B. R., DeCarli, C. S., Madison, C. M., Weiner, M. W., Chui, H. C., & Jagust, W. J.
- Affiliations
- Lawrence Berkeley National Laboratory (US)
- University of California, Davis (US)
- University of California, Berkeley (US)
- University of California, San Francisco (US)
- University of Southern California (US)
- Corresponding author
- Marchant, Natalie L.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 33
- Issue
- 5
- Pages
- 1006.e25-1006.e36
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC3274647
- OpenAlex
- W1972661606
- Cited by
- 127
- References
- 86
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 13 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 10 · 2018: 10 · 2017: 3 · 2016: 15 · 2015: 11 · 2014: 15 · 2013: 13 · 2012: 5
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institutes of Health (AG012435, AG034570)
- Alzheimer's Association (ZEN-08-87090)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
- Keywords
- cerebrovascular disease, amyloid-beta, cognitive aging, white matter hyperintensities, cerebral infarction, Pittsburgh compound B PET, executive function, episodic memory, normal aging, Alzheimer's disease
- MeSH terms
- Aged, Aged, 80 and over, Aging, Cerebrovascular Disorders, Cognition, Female, Humans, Male, Risk Factors, Cohort Studies, Amyloid beta-Peptides, Executive Function, Cognitive Dysfunction, Memory, Episodic
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